Skip to main content

Endocrine Hyperfunctional Syndromes by Ectopic Hormone Formation (Paraneoplastic Syndromes)

  • Chapter
Clinical Endocrinology
  • 275 Accesses

Abstract

Ectopic formation of hormones means the production of most probably normal hormones by tumors of tissues which normally form no hormones or different hormones. These tumors are with few exceptions malignant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Ectopic Hormones

  • Azzopardi, J.G., Williams, D.D.: Pathology of nonendocrine tumors associated with Cushing’s syndrome. Cancer (Philad.) 22, 274 (1968).

    Article  CAS  Google Scholar 

  • Becker, K.L., Cottrell, J., Moore, CH. F., Winnacker, J.L., Matthews, M. J., Katz, S.: Endocrine studies in a patient with a gonadotropin-secreting bronchogenic carcinoma. J. clin. Endocr. 28, 809 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Bowers, B. F., Gordan, G.S.: Hormonal effects of nonendocrine tumors. Ann. Rev. Med. 16, 83 (1965).

    Article  Google Scholar 

  • Brown, W.H.: Case of pluriglandular syndrome; “diabetes of bearded women”. Lancet 1928 II, 1022.

    Article  Google Scholar 

  • Christy, N. P.: Adrenocorticotrophic activity in the plasma of patients with Cushing’s syndrome associated with pulmonary neoplasms. Lancet 1961 I, 85

    Article  Google Scholar 

  • Donahower, G.F., Schumacher, O.B., Hazard, J.B.: Medullary carcinoma of the thyroid—a cause of Cushing’s syndrome—report of two cases. J. chn. Endocr. 28, 1199 (1968).

    Article  CAS  Google Scholar 

  • Faiman, CH., Colwell, J. A., Ryan, R.J., Hershman, J. M., Shields, TH. W.: Gonadotropin secretion from a bronchogenic carcinoma. New Engl. J. Med. 277, 1395 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Froesch, E. R., Jacob, A., Labhart, A.: Hypoglykämie bei extrapankrealen Tumoren. In: Nebenschilddrüse und endokrine Regulation des Calciumstoffwechsels. Spontanhypoglykämie Glucagon (Ed. by Kracht, J.). Berlin Heidelberg-New York: Springer 1968.

    Google Scholar 

  • Fusco, F.D., Rosen, S.W.: Gonadotropin-producing anaplastic large-cell carcinomas of the lung. New Engl. J. Med. 275, 507 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Gardner, B.: Hypercalcemia and malignancy. J. Amer. med. Ass. 204, 24 (1968).

    Google Scholar 

  • Ginsburg, J., Brown, J.B.: Increased oestrogen excretion in hypertrophic pulmonary osteoarthropathy. Lancet 1961 II, 1274.

    Article  Google Scholar 

  • Gleeson, M.H., Bloom, S.R., Polak, J.M., Henry, K., Dowling, R. H.: Endocrine tumor in kidney affecting small bowel structure, motility and absorptive function. Gut 12, 773 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Gordan, G.S., Fitzpatrick, N.E., Lubitch, W. P.: Identification of osteolytic sterols in human breast cancer. Trans. Ass. Amer. Phycns 80, 183 (1967).

    CAS  Google Scholar 

  • Greenberg, P. B., Beck, C., Martin, T. J., Burger, H. G.: Synthesis and release of human growth hormone from lung carcinoma in ceh culture. Lancet 1972 I, 350.

    Article  Google Scholar 

  • Haas, H.G.: Endokrine Überfunktion bei malignen Tumoren. Praxis 18, 610 (1964).

    Google Scholar 

  • Huguenin, R., Fauvet, J., Piérat, A., LéObardy, J. DE: Le syndrome «cancer bronchopulmonaire, périostite des os longs, gynécomastie». Bull. Soc. méd. Hôp. Paris 70, 986 (1954).

    PubMed  CAS  Google Scholar 

  • Jakob, A., Meyer, U.A., Flury, R., Ziegler, W.H., Labhart, A., Froesch, E. R.: The pathogenesis of tumor hypoglycemia: Blocks of hepatic glucose release and of adipose tissue lipolysis. Diabetologia 3, 506 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Jones, J.E. Shane, S.R., Gilbert, E., Flink, E.B.: Cushing’s syndrome induced by the ectopic production of ACTH by a bronchial carcinoid. J. clin. Endocr. 29, 1 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Katz, A., Kaplan, L., Massry, S. G., Heller, R., Plotkin, D., Knight, I.: Primary hyperparathyroidism in patients with breast carcinoma.

    Google Scholar 

  • Kracht, J.: Pathologie der ektopisch hormonbildenden Tumoren. Verh. dtsch. Ges. inn. Med. 73, 488 (1967).

    PubMed  CAS  Google Scholar 

  • Labhart, A.: Endokrine Überfunktionssyndrome der Gewebehormone. In: Gewebe- und Neurohormone. Physiologie des Melanophorenhormons. 8. Symp. Dtsch. Ges. Endokr. Berlin-Göttingen-Heidelberg: Springer 1962.

    Google Scholar 

  • Law, D. H., Liddle, G. W., Scott, H. W., JR., Tauber, ST.D.: Ectopic production of multiple hormones (ACTH, MSH and Gastrin) by a single malignant tumor. New Engl. J. Med. 273, 292 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Liddle, G. W., Givens, J. R., Nicholson, W. E., Island, D. P.: The ectopic ACTH syndrome. Cancer Res. 25, 1057 (1965).

    PubMed  CAS  Google Scholar 

  • Nicholson, W.E., Island, D.P., Orth, D.N., Abe, K., Lowder, S.C.: Clinical and laboratory studies of ectopic humoral syndromes. Recent Progr. Hormone Res. 25, 283 (1969).

    CAS  Google Scholar 

  • Lipsett, M.B.: Hormonal syndromes associated with neoplasia. Advances in metabol. disorders 3, 112 (1968).

    Google Scholar 

  • Odell, W.D., Rosenberg, L. E., Waldmann, TH.A.: Humoral syndromes associated with nonendocrine tumors. Ann. intern. Med. 61, 733 (1964).

    PubMed  CAS  Google Scholar 

  • O’neal, L. W.: Secretion of various endocrine substances by ACTH-secreting tumors: gastrin, melanotropin, norepinephrin, serotonin, parathormone, vasopressin, glucagon. Cancer (Philad.) 21, 1219 (1968).

    Article  Google Scholar 

  • Rosen, S. W., Becker, CH. E., Schlaff, S., Easton, J., Gluck, M.C.: Ectopic gonadotropin production before clinical recognition of bronchogenic carcinoma. New Engl. J. Med. 279, 640 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Ross, E.J.: The cancer cell as an endocrine organ. In: James, Recent advances in endocrinology, 8th ed. London: Churchill 1968.

    Google Scholar 

  • Ross, E.J.: Endocrine and metabohc manifestations of Cancer. Brit, med. J. 1972 I, 735.

    Article  Google Scholar 

  • Sandler, M., Karim, S. M. M., Williams, E. D.: Prostaglandins in amine-peptide-secreting tumors. Lancet 1968 II, 1053.

    Article  Google Scholar 

  • Sparagana, M., Phillips, G., Hoffman, C., Kucera, L.: Ectopic growth hormone syndrome associated with lung cancer. Metabolism 20, 730 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Steiner, H., Dahlbäck, O., Waldenström, J.: Ectopic growth hormone production and osteoarthropathy in carcinoma of the bronchus. Lancet 1968 I, 783.

    Article  Google Scholar 

  • Strott, CH. A., Nugent, CH. A., Tyler, F. H.: Cushing’s syndrome caused by bronchial adenomas. Amer. J. Med. 44, 97 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Studer, H., Staub, J.J., Wyss, F.: Klinische und metabolische Fernwirkungen maligner Tumoren. Schweiz, med. Wschr. 101, 446 (1971).

    CAS  Google Scholar 

  • Tamm, J.: Die Klinik paraneoplastischer Endokrinopathien. Verh. dtsch. Ges. inn. Med. 73, 481 (1967).

    PubMed  CAS  Google Scholar 

  • Turkington, R.W.: Ectopic production of prolactin. New Engl. J. Med. 285, 1455 (1971).

    CAS  Google Scholar 

  • Upton, G. V., Amatruda, Th. T,JR.: Evidence for the presence of tumor peptides with corticotropin releasing factor-like activity in the ectopic ACTH syndrome. New Engl. J. Med. 285, 419 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Vorherr, H., Massry, S.G., Utiger, R.D., Kleeman, C.R.: Antidiuretic principle in malignant tumor extracts from patients with inappropriate ADH syndrome. J. chn. Endocr. 28, 162 (1968).

    Article  CAS  Google Scholar 

  • Waldenström, J.: Maladies of derepression. Schweiz. med. Wschr. 100, 2197 (1970).

    Google Scholar 

  • Weichert, R. F.: The neural ectodermal origin of the peptidesecreting endocrine glands. Amer. J. Med. 49, 232 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Weintraub, B.D., Rosen, S.W.: Ectopic production of human somatomammotrophin by nontrophoblastic cancers. J. clin. Endocr. 32, 94 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Williams, E.D., Karim, S. M.M., Sandler, M.: Prostaglandin secretion by medullary carcinoma of the thyroid. Lancet 1968 I, 22.

    Article  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Labhart, A. (1974). Endocrine Hyperfunctional Syndromes by Ectopic Hormone Formation (Paraneoplastic Syndromes). In: Clinical Endocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96158-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96158-8_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96160-1

  • Online ISBN: 978-3-642-96158-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics