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Phosphatidylethanol; clinical significance and biochemical basis

  • Conference paper
New and Upcoming Markers of Alcohol Consumption

Abstract

As shown in figure 1, ethanol can be metabolized by oxidative and nonoxidative pathways (Lieber, 1995). In the oxidative pathway, ethanol is converted to acetal-dehyde through the action of alcohol dehydrogenases, the microsomal ethanol-oxidizing system, or catalase. Acetaldehyde is then subsequently metabolized to acetate through the action of aldehyde dehydrogenases. In one of the nonoxidative pathways of ethanol metabolism, ethanol undergoes esterification with fatty acids by the action of fatty acid ethyl ester synthase to form fatty acid ethyl esters. The nonoxidative ethanol pathway that is the focus of this review is the pathway leading to the synthesis of phosphatidylethanol. Figure 1 shows how ethanol can be inserted as the head group of a phospholipid to form phosphatidylethanol. The transformation occurs through the activation of phospholipase D, mainly on phosphatidylcholine in the presence of ethanol.

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Authors and Affiliations

  1. Department of Medical Neurochemistry, Institute of Laboratory Medicine, Lund University Hospital, SE-221 85, Lund, Sweden

    Arthur Varga, Kristian Moller, Per Hansson, Steina Aradottir & Christer Alling

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  4. Steina Aradottir
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  5. Christer Alling
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  1. Psychiatric University Hospital, Wilhelm-Klein-Strasse 27, CH-4025, Basel, Switzerland

    Friedrich M. Wurst

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© 2001 Steinkopff Verlag Darmstadt

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Varga, A., Moller, K., Hansson, P., Aradottir, S., Alling, C. (2001). Phosphatidylethanol; clinical significance and biochemical basis. In: Wurst, F.M. (eds) New and Upcoming Markers of Alcohol Consumption. Steinkopff. https://doi.org/10.1007/978-3-642-96008-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-96008-6_6

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-96010-9

  • Online ISBN: 978-3-642-96008-6

  • eBook Packages: Springer Book Archive

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