Tumor Immunology

  • Marcus E. Peter
  • Peter H. Krammer
  • Wulf Dröge


The work of the Research Program is concentrated on new immunological methods of tumor diagnostics as well as on immunological concepts for tumor therapy and the investigation of the biological mechanisms underlying processes of cellular interaction and metastatic spreading.


Chronic Fatigue Syndrome Rhesus Macaque Skeletal Muscle Tissue Simian Immunodeficiency Virus Infection Body Cell Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selected publications

  1. Kischkel, F.C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P.H., Peter, M.E.: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated Proteins Form a Death-inducing Signalling Complex (DISC) with the Receptor. EMBO J. 14, 5579–5588 (1995)Google Scholar
  2. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., Wallach, D.: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85, 803–815 (1996)Google Scholar
  3. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O’ Rourke, K., Shevchenko, A., Scaffidi, C., Zhang, M., Ni, J., Gentz, R., Mann, M., Krammer, PH., Peter, M.E., Dixit, V.M.: FLICE, a Novel FADD-homologous ICE/CED-3-like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex (DISC). Cell 85, 817–827 (1996)PubMedCrossRefGoogle Scholar
  4. Eck, H.-P., Stahl-Hennig, C., Hunsmann, G., Dröge, W.: Metabolic disorder as an early consequence of simian immunodeficiency virus infection in rhesus macaques. Lancet 338, 346–347 (1991)PubMedCrossRefGoogle Scholar
  5. Dröge, W., Eck, H.-P., Mihm, S.: HIV-induced cysteine deficiency and T-cell dysfunction - a rationale for treatment with N-acetyl-cysteine. Immunol. Today 13, 211–214 (1992)PubMedCrossRefGoogle Scholar
  6. Groß, A., Hack, V., Stahl-Hennig, C., Dröge, W.: Elevated hepatic γ-glutamylcysteine syn¬thetase activity and abnormal sulfate levels in liver and muscle tissue may explain abnor¬mal cysteine and glutathione levels in SlV-in- fected rhesus macaques. AIDS Res. and Human Retroviruses 12, 1639–1641 (1996)CrossRefGoogle Scholar
  7. Hack, V., Groß, A., Kinscherf, R., Bockstette, M., Fiers, W., Berke, G., Dröge, W.: Abnormal glutathione and sulfate levels after interleukin-6 treatment and in tumor-induced cachexia. FASEB J. 10, 1219–1226 (1996)Google Scholar
  8. Kinscherf, R., Hack, V., Fischbach, T., Friedmann, B., Weiss, C., Edler, L., Bartsch, P., Droge, W.: Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine. J. Mol. Med. 74, 393–400 (1996)PubMedCrossRefGoogle Scholar
  9. Hack, V., Schmid, D., Breitkreutz, R., Stahl- Hennig, C., Drings, P., Kinscherf, R., Taut, F., Holm, E., Dröge, W.: Cystine levels, cystine flux and protein catabolism in cancer cachexia, HIV/SIV infection and senescence. FASEB J. 11, 84–92 (1997)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Marcus E. Peter
    • 1
  • Peter H. Krammer
    • 1
  • Wulf Dröge
    • 2
  1. 1.Division of ImmunogeneticsGermany
  2. 2.Division of ImmunochemistryGermany

Personalised recommendations