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Indikationsstellungen für den Einsatz von Immunstimulanzien und Strategien für den klinisch-immunologischen Wirksamkeitsnachweis

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Phytopharmaka III

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Zusammenfassung

Eine Stimulation des Immunsystems durch Medikamente, im Schrifttum auch etwas ungenauer als Immunmodulation bezeichnet, dient dem Zweck einer forcierten Elimination von Antigenen aus dem Organismus. Das Immunnetzwerk im engeren Sinne - der Begriff wurde von Nils Jerne [34] geprägt - kooperiert dabei mit einer Serie von vor- und nachgeschalteten Systemen unterschiedlicher Spezifität (Abb. 1). Die Gesamtheit wird als Körperabwehr bezeichnet. Die systematische Aktivierung dieser Systeme führt zu einer typischen Entzündungsreaktion. Es kann sogar unter bestimmten Voraussetzungen, wie zum Beispiel schweren Grunderkrankungen, Vorliegen von Tumoren, Polytraumatisierung oder nach schweren Operationen, zu lebensbedrohlichen Zuständen, wie Sepsis oder Tumorentstehung kommen, wenn die Entzündungsreaktion eskaliert und die Abwehrsituation insuffizient ist oder fehlgesteuert wird.

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  1. Biotest Pharma GmbH, D-63303, Dreieich, Deutschland

    PD Dr. R. Lissner & W. G. Struff

  2. Laborgemeinschaft Keeser/Arndt, Hamburg, Deutschland

    Th. Meyer, F. Korioth & R. Arndt

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  1. PD Dr. R. Lissner
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  1. Abteilung für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Haus 74 Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland

    Dieter Loew  & Norbert Rietbrock  & 

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Lissner, R., Meyer, T., Korioth, F., Struff, W.G., Arndt, R. (1997). Indikationsstellungen für den Einsatz von Immunstimulanzien und Strategien für den klinisch-immunologischen Wirksamkeitsnachweis. In: Loew, D., Rietbrock, N. (eds) Phytopharmaka III. Steinkopff. https://doi.org/10.1007/978-3-642-95993-6_5

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