Zusammenfassung
Maligne Erkrankungen stellen derzeit nach Herz-Kreislauf-Erkrankungen die zweithäufigste Todesursache in den Industrieländern dar und machen etwa 20%–25% aller Todesfälle aus. Etwa 1 Million neue Krebserkrankungen werden jährlich in den USA diagnostiziert, die Anzahl krebsbedingter Todesfälle pro Jahr beträgt etwa eine halbe Million [66]. Die Tumor- inzidenz bzw. -mortalität in den EU-Ländern ist ähnlich: In den 12 Ländern der Europäischen Union mit einer gesamten Population von etwa 327 x 106 werden jährlich 1,2 Millionen Neuerkrankungen sowie etwa 800.000 krebsbedingte Todesfälle gezählt [8, 34, 36].
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Literatur
Abel G, Schimmer O (1983) Induction of structural chromosome aberrations and sister chromatid exchanges in human lymphocytes in vitro by aristolochic acid. Human Gen 64: 131–133
Batsford S, Kluthe R, Vogt A (1982) Double blind study on the influence of aristolochic acid on granulocyte phagocytic acitivty. Arzneimittelforschung 32: 443–445
Bertram B (1989) Flavonoide. Eine Klasse von Pflanzeninhaltstoffen mit vielfältigen biologischen Wirkungen, auch mit carcinogener Wirkung?. Dtsch Apoth Ztg 129: 2561–2571
Brown JP, Dietrich PS (1979) Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test. Activation of flavonol glycosides by mixed glycosidase from rat cecal bacteria and other sources. Mutat Res 66: 223–240
Brown JP, Dietrich PS, Brown RJ (1977) Frameshift mutagenicity of certain naturally occuring phenolic compounds in the Salmonella/microsome test. Activation of anthraquinone and flavonol glycosides by gut bacterial enzymes. Biochem Soc Trans 5: 1489–1492
Brown JP (1980) A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutat Res 75: 243–277
Bundesgesundheitsamt (1982): Deutsche Apotheker Zeitung 122: 2287
Cancer in the European Community. Eur Cancer News 5(1992): 1–7
Carins J (1986) Das Krebsproblem. In: Schirrmacher V (Hrsg) Krebs-Tumoren, Zellen, Gene. Spektrum der Wissenschaften, Heidelberg S10–21
Carver JH, Carrano AV, MacGregor JT (1983) Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells in vitro. Mutat Res 113: 45–60
Crebelli R, Auilina G, Falcone E, Careere A (1987) Urinary and fecal mutagenicity in Sprague-Dawley rats dosed with the food mutagens quercetin and rutin. Food Chem Toxicol 25, 9–15
Frei H, Würgler FE, Juon H, Hall CB, Graf U (1985) Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests. Arch Toxicol 56: 158–166
Gaspar J, Rodrigues A, Laires A, Silva F, Costa S, Monteiro MJ, Monteiro C, Rueff J (1994) On the mechanisms of genotoxicity and metabolism of quercetin. Mutagenesis 9: 445–449
Götzl E, Schimmer O (1993) Mutagenicity of aristolochic acids (I, II) and aristolochic acid I in new YG strains in Salmonella typhimurium highly sensitive to certain mutagenic nitroarens. Mutagenesis 8: 17–22
Hang BQ, Wu Y, Hang S, Yang Y, Wang MS (1985) Effect of quercetin and rutin on the occurence of micronuclei in mouse bone-marrow polychromatic erythrocytes. J Nanjing Coll Pharm 16: 52–55
Hankey BF (1992) Trends in U.S. Cancer Mortality by Age Group, 1973-1989. J Natl Cancer Inst 84: 1391
Herrmann K (1988) On the occurrence of flavonol and flavone glycoside in vegetables. Z Lebensm Unters Forsch 186: 1–5
Hertog MGL, Hollman PCH, Katan MB (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem 40: 2379–2383
Hirono I (1992) Is quercetin carcinogenic? Jpn J Cancer Res 83: 313–314
Hirono I, Ueno I, Hosaka S, Takanashi H, Matsushima T, Sugimura T, Natori S (1981) Carcinogenicity examination of quercetin and rutin in ACI rats. Cancer Lett 13: 15–21
Hosaka S, Hirono I (1981) Carcinogenicity test of quercetin by pulmonary adenoma bioassay in strain A mice. Gann 72: 327–328
Huang MT, Wood AW, Newmark HL, Sayer JM, Yagi H, Jerina DM, Conney AH (1983) Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant fla-vonoids. Carcinogenesis 4: 1631–1637
Ishikawa M, Oikawa T, Hosokawa M, Hamada J, Morikawa K, Kobayashi H (1985) Enhancing effect of quercetin on 3-methylcholanthrene carcinogenesis in C57B1/6 mice. Neoplasma 32: 435–441
Ito N, Hagiwara A, Tamano S, Kagawa M, Shibata M, Kurata Y, Fukushima S (1989) Lack of carcinogenicity of quercetin in F344/DuCrj rats. Jpn J Cancer Res 80: 317–325
Ito N (1992) Is quercetin carcinogenic? Jpn J Cancer Res 83: 312–313
Kato R, Nakadate T, Yamamoto S, Sugimura T (1983) Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis 4: 1301–1305
Komatsu N, Nawata H, Kimino T, Ahoji J, Tada A (1973) Biological activities of aristolochic acid. II. Effect on experimental tumor, bacterial infection and RES (reticuloendothelial system) function. Showa Igakkai Zasshi 33: 776–782
Maier P, Schawalder HP, Weibel B, Zbinden G (1985) Aristolochic acid induces 6-thioguanineresistant mutants in an extra hepatic tissue in rats after oral application. Mutat Res 108: 143–148
Marks F, Schwarz M, Förstenberger G (1995) Promotion and Carcinogenesis. In: Arcos JC (ed) Chemical Induction of Cancer. Birkhäuser, Boston, pp 123–184
Meltz ML, MacGregor JT (1981) Activity of the plant flavonol quercetin in the mouse lymphoma L 5178y TK+/-mutation, DNA single-strand break and Balb/c3T3 chemical transformation assays. Mutat Res 88: 317–324
Mengs U (1983) On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52: 209–220
Mengs U, Lang W, Poch JA (1982) The carcinogenic action of aristolochic acid in rats. Arch Toxicol 51: 107–119
Möse JR (1975) The effect of aristolochic acid on the development of methylcholanthrene tumors in mice. Oesterr Z Onkol 2: 151–153
Moller JO, Esteve J, Moller H, Renard H (1990) Cancer in the European Community and its member states. Eur J Cancer 26(11/12)
Morino K, Matsukura N, Kawachi T, Ohgaki H, Sugimura T, Hirono I (1982) Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration. Carcinogenesis 3: 93–97
Muir CS, Boyle P (1990) The burden of cancer in Europe. Eur J Cancer 26: 1111–1113
National Toxicology Program, Research Triangle Park, NC, 27709, USA (1991) NTP technical report on the toxicology and carcinogenesis studies of quercetin in F344/N rats. Natl Toxicol Program Tech Rep Ser 409
Ngomuo AJ, Jones RS (1996) Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats. Vet Hum Toxicol 38: 176–180
Nishino H, Nishino A, Iwashima A, Tanaka K, Matsuura T (1984) Quercetin inhibits the action of 12-O-tetradecanoylphorbol 13-acetate, a tumor promotor. Oncology 41: 120–123
Ogawa S, Hirayama T, Nohara M, Tokuda M, Hirai K, Fukui S (1985) The effect of quercetin on the mutagenicity of 2-acetylaminofluorene and benzo[a]pyrene in Salmonella typhimurium strains. Mutat Res 142: 103–107
Ogawa S, Hirayama T, Tokuda M, Hirai K, Fukui S (1986) The effect of quercetin, a mutagenicity-enhan-cing agent, on the metabolism of 2-acetylaminofluorene with mammalian metabolic activation systems. Mutat Res 162: 179–186
Pamukcu AM, Yalciner S, Hatcher JF, Bryan GT (1980) Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res 40: 3468–3472
Pereira MA, Grubbs CJ, Barnes LH, Li H, Olson GR, Eto I, Juliana M, Whitake LM, Kelloff GJ et al (1996) Effects of the phytochemicals, curcumin and quercetin, upon azoxymethaneinduced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Carcinogenesis 17: 1305–1311
Pfau W, Pool-Zobel BL, von der Lieth CW, Wiessler M (1990) The structural basis for the mutagenicity of aristolochic acid. Cancer Lett 55: 7–11
Pfau W, Schmeiser HH, Wiessler M (1991) N6-Adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen. Chem Res Toxicol 4: 581–586
Robisch G, Schimmer O, Goeggelmann W (1982) Aristolochic acid is a direct mutagen in Salmonella typhimurium. Mutat Res 105: 201–204
Sahu RK, Basu R, Sharma A (1981) Genetic toxicological testing of some plant flavonoids by the micronucleus test. Mutat Res 89: 69–74
Sahu SC, Gray GC (1996) Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-trans-ferase in isolated rat liver nuclei. Cancer Lett 104: 193–196
Saito D, Shirai A, Matsushima T, Sugimura T, Hirono I (1980) Test of carcinogenicity of quercetin, a widely distributed mutagen in food. Teratog Carcinog Mutagen 1: 213–221
Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP (1996) Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 56: 2025–2028
Schmeiser HH, Pool BL, Wiessler M (1984) Mutagenicity of the two components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium. Cancer Lett 23: 97–101
Schmeiser HH, Schoepe KB, Wiessler M (1988) DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis 9: 297–303
Schmeiser HH, Wiessler M (1995) Carcinogene Naturstoffe. Bioforum 18: 306–311
Stoewsand GS, Anderson JL, Boyd JN, Hrazdina G, Babish JG, Walsh KM, Losco P (1984) Quercetin: a mutagen, not a carcinogen, in Fisher rats. J Toxicol Environ Health 14: 105–114
Shunack W, Mutschier E, Rochelmeyer H (1967) Influence of aristolochic acids I and II on the survival rate of mice infected with pneumococci. Arzneimittelforschung 17: 1215–1218
Taj S, Nagarajan B (1996) Inhibition by quercetin and luteolin of chromosomal alterations induced by salted, deep-fried fish and mutton in rats. Mutat Res 369: 97–106
Takanashi H, Aiso S, Hirono I, Matsushima T, Sugimura T (1983) Carcinogenicity test of quercetin and kaempferol in rats by oral administration. J Food Safety 5: 55–60
Umezawa K, Matsushima T, Sugimura T, Hirakawa T, Tanaka M, Katoh Y, Takayama S (1977) In vitro transformation of hamster embryo cells by quercetin. Toxicol Lett 1: 175–178
Van Duuren BL, Goldschmidt BM (1976) Carcinogenic and tumor-promoting agents in tobacco carcinogenesis. J Natl Cancer Inst 56: 1237–1242
Van der Hoeven JCM, Bruggeman IM, Debets FMH (1984) Genotoxicity of quercetin in cultured mammalian cells. Mutat Res 136: 9–21
Vanherweghem JL, Depierreux M, Tielemens C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vander-welde D, Verbeelen D, Vanhaelen-Fastre R, Vanhaelen M (1993) Rapidly progressive interstitial renal fibrosis in young women: association with a slimming regimen including Chinese herbs. Lancet 341: 387–391
Vanhaelen M, Vanhaelen-Fastre R, But P, Vanherweghem JL (1994) Identification of aristolochic acid in Chinese herbs. Lancet 343: 174
Wagner H, Porksch A, Vollmer A, Kreutzkamp B, Bauer J (1985) In vitro phagocytosis stimulation by isolated plant materials measured in the phagocytosis-chemoluminescence (CL) model. Plant Med 51: 139–144
Wang CY, Pamukcu AM, Bryan GT (1976) Bracken fern, a naturally occurring carcinogen. In: Stock CC, Santamaria L, Mariani P, Gorin S (eds) Ecological Perspectives on Carcinogens and Cancer Control (Medicine, Biology, Environment), Harger, Basel, pp 565–572
Watson WAF (1982) The mutagenic activity of quercetin and kaempferol in Drosophila melanogaster. Mutat Res 103: 145–147
Weinstein IB (1991) Cancer prevention: recent progress and future opportunities. Cancer Res (Suppl) 51:5080s-5080s
Yoshida MA, Sasaki M, Sugimura K, Kawachi T (1980) Cytogenetic effects of quercetin on cultured mammalian cells. Proc Jpn Acad [B] 56: 443–447
Zhu BT, Ezell EL, Liehr JG (1994) Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo. J Biol Chem 269: 292–299
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© 1997 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
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Eisenbrand, G., Tang, W. (1997). Nutzen und Grenzen von Mutagenitäts- und Kanzerogenitätsstudien. In: Loew, D., Rietbrock, N. (eds) Phytopharmaka III. Steinkopff. https://doi.org/10.1007/978-3-642-95993-6_1
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