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Mechanical Circulatory Support pp 83–91Cite as

Agonistic anti-β1-adrenoceptor autoantibodies in the serum of patients with dilated cardiomyopathy

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Abstract

Idiopathic dilated cardiomyopathy (DCM) is per definition a disease of unknown cause (31). However, one of the pathogenic factors observed in patients with this disease is in all probability a chronic adrenergic overdrive (22, 9, 2). Cellular and humoral autoimmune processes may also play a role in the development and maintenance of the DCM. In the blood serum of DCM patients autoantibodies were found that recognize sarcolemmal, myofibrillar, and mitochondrial structures in the cardiac myocytes (15, 16). Moreover, autoantibodies to some of these structures were able to influence the function of the myocytes (19, 25). For example, Schult-heiss and coworker (20) described an autoantibody directed against the mitochondrial ADP/ATP carrier which cross-react with the sarcolemmal L-type Ca++channel (17). This autoantibody was able to reduce the cytosolic ATP concentration and to increase the sarcolemmal Ca++current into the myocytes.

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Author information

Authors and Affiliations

  1. Cardiology, Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, 13125, Berlin, Germany

    Dr. G. Wallukat & A. Wollenberger

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  1. Dr. G. Wallukat
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  2. A. Wollenberger
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Editors and Affiliations

  1. German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    R. Hetzer , E. Hennig  & M. Loebe ,  & 

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© 1997 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Wallukat, G., Wollenberger, A. (1997). Agonistic anti-β1-adrenoceptor autoantibodies in the serum of patients with dilated cardiomyopathy. In: Hetzer, R., Hennig, E., Loebe, M. (eds) Mechanical Circulatory Support. Steinkopff. https://doi.org/10.1007/978-3-642-95984-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-95984-4_8

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-95986-8

  • Online ISBN: 978-3-642-95984-4

  • eBook Packages: Springer Book Archive

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