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Agonistic anti-β1-adrenoceptor autoantibodies in the serum of patients with dilated cardiomyopathy

  • G. Wallukat
  • A. Wollenberger
Conference paper

Abstract

Idiopathic dilated cardiomyopathy (DCM) is per definition a disease of unknown cause (31). However, one of the pathogenic factors observed in patients with this disease is in all probability a chronic adrenergic overdrive (22, 9, 2). Cellular and humoral autoimmune processes may also play a role in the development and maintenance of the DCM. In the blood serum of DCM patients autoantibodies were found that recognize sarcolemmal, myofibrillar, and mitochondrial structures in the cardiac myocytes (15, 16). Moreover, autoantibodies to some of these structures were able to influence the function of the myocytes (19, 25). For example, Schult-heiss and coworker (20) described an autoantibody directed against the mitochondrial ADP/ATP carrier which cross-react with the sarcolemmal L-type Ca++channel (17). This autoantibody was able to reduce the cytosolic ATP concentration and to increase the sarcolemmal Ca++current into the myocytes.

Keywords

Dilate Cardiomyopathy Extracellular Loop Idiopathic Dilate Cardiomyopathy Acute Myocarditis Positive Chronotropic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1997

Authors and Affiliations

  • G. Wallukat
    • 1
  • A. Wollenberger
    • 1
  1. 1.CardiologyMax Delbrück Centre for Molecular MedicineBerlinGermany

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