Skip to main content

Mechanismen der Schädigung parenchymatöser Organe

  • Conference paper
  • First Online:
Poison Control Entgiftungsprobleme

Part of the book series: Aktuelle Probleme der Intensivmedizin ((API,volume 1))

  • 40 Accesses

Zusammenfassung

Die Verhandlungen des heutigen Vormittags stehen unter dem Gesichtspunkt der Organbezogenheit von Giften. Dieser Begriff soll zum Ausdruck bringen, daß bei systemischen Vergiftungen der Schadstoff sich zwar im gesamten Organismus verteilt, daß aber nur an bestimmten Organen oder Organsystemen Vergiftungssymptome, zumindest solche primärer Art, beobachtet werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Brodie, B. B., Reid, W. D., Cho, A. K., Sipes, G., Krishna, G. and Gillette, J. R., Possible mechanism of liver necrosis caused by aromatic organic compounds. Proc. Nat. Acad. Sci. 68, 160–164 (1971).

    Article  CAS  Google Scholar 

  2. Brodie, B. B., Cho, A. K., Krishna, G. and Reid, W. D., Drug metabolism in man: past, present and future, in: Drug metabolism in man, ed. by E. G. Vesell, Ann. New York Acad. Sci. 179, 11 (1971).

    Google Scholar 

  3. Eichelbaum, M., Hengstmann, J. H. and Dengler, H. J., Das Verteilungsmuster des Chlorphentermins bei Ratte, Kaninchen und Schwein. Naunyn-Schmiedebergs-Arch. exp. Pharmak. 267, 446–456 (1970).

    Article  CAS  Google Scholar 

  4. Krishna, G., Eichelbaum, M. and Reid, W. D., Isolation and characterization of liver proteins containing covalently bound C14-bromobenzene metabolites. Pharmacologist 13(2), 196 (1971).

    Google Scholar 

  5. Maling, H. M., Eichelbaum, M., Highman, B., Brown, E. A. B., Saul, W. and Williams, M. A., Protection by dibenamine pretreatment against hepatotoxicity induced by CCl4, dimethylnitrosamine, or thioacetamide. Fifth Intern. Congress on Pharmacology, San Francisco, 23.–27. 7. 1972.

    Google Scholar 

  6. Mitchell, J. R., Davis, D. C., Potter, W. Z., Jollow, D., Gillette, J. R. and Brodie, B. B., Acetaminophen — induced hepatic necrosis. I. Species differences in necrosis and covalent binding. Abstr. Vth. Intern. Congress Nr. 953.

    Google Scholar 

  7. Mitchell, J. R., Reid, W. D., Christie, B., Moskowitz, J., Krishna, G. and Brodie, B. B., Bromobenzene induced hepatic necrosis: Species differences and protection by SKF 525-A, Res. Commun. Chem. Pathol. Pharmacol.

    Google Scholar 

  8. Potter, W. Z., Jollow, D., Davis, D. C., Mitchell, J. R., Gillette, J. R. and Brodie, B. B., Acetaminophen — induced hepatic necrosis. II. Comparison of necrosis with covalent binding of acetaminophen in vivo. Abstr. Vth. Int. Congress Nr. 1105.

    Google Scholar 

  9. Rees, K. R. and Tarlow, M. J., Biochem. J. 104, 757 (1967).

    Article  CAS  Google Scholar 

  10. Reid, W. D., Christie, B., Krishna, G., Mitchell, J. R., Moskowitz, J. and Brodie, B. B., Bromobenzene metabolism and hepatic necrosis. Molec. Pharmacol. ●, … (1999).

    Google Scholar 

  11. Reid, W. D., Christie, B., Eichelbaum, M. and Krishna, G., 3-methylcholanthrene blocks hepatic necrosis induced by administration of bromobenezene or carbon tetrachloride. Exp. Molec. Pathology 15(3), 363–372 (1971).

    Article  CAS  Google Scholar 

  12. Reid, W. D., Eichelbaum, M., Christie, B. and Brodie, B. B., Mechanism of bromo-benzene hepatotoxicity. I. Studies in vivo. Fed. Proc. 30(2), 1359 (1971).

    Google Scholar 

  13. Sipes, I. G., Corsini, G., Krishna, G. and Gillette, J. R., Studies on the covalent binding of carbon tetrachloride and chloroform to liver microsomes. Abstr. Vth. Int. Congress Nr. 1287.

    Google Scholar 

  14. Stripp, B., Sipes, I. G., Corsini, G., Suria, A., Maling, H. M. and Gillette, J. R., Protective effects of dibenamine pretreatment against CCU induced changes in microsomal mixed function oxidase system. Vth. Int. Congress on Pharmacology San Francisco, 23.-27. 7. 1972.

    Google Scholar 

  15. Udenfriend, S., Arene oxide intermediates in enzymatic hydroxylation and their significance with respect to drug toxicity. Ann. New York. Acad. Sci. 179, 295–301 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Dr. Dietrich Steinkopff Verlag, Darmstadt

About this paper

Cite this paper

Dengler, H.J., Eichelbaum, M. (1974). Mechanismen der Schädigung parenchymatöser Organe. In: Tombergs, H.P. (eds) Poison Control Entgiftungsprobleme. Aktuelle Probleme der Intensivmedizin, vol 1. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-95952-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95952-3_14

  • Published:

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-0394-6

  • Online ISBN: 978-3-642-95952-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics