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Allogene Knochenmarktransplantation Beim Menschen

  • Conference paper
Knochenmark-Insuffizienz

Part of the book series: Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 16))

Zusammenfassung

Knochenmark besteht aus hämopoetischen Stammzellen (HSC) sowie Zellen der myeloiden, der erythroiden, der megakaryozytären und der lymphoiden Linien; zusätzlich finden sich retikuloendotheliale Zellen. Definitionsgemäß hat die HSC die Fähigkeit der identischen Reduplikation, d.h. die Fähigkeit, andere Stammzellen mit gleichen Eigenschaften zu produzieren, andererseits kann sie in eine der genannten vier Zellinien differenzieren. Nach intravenöser Applikation von Knochenmarkzellen (Knochenmarktransplantation) bei letal bestrahlten Empfängertieren ist es die HSC, die verantwortlich ist für die Repopulation der hämopoetischen Organe, einschließlich des lymphatischen Systems. Für dieses Konzept spricht besonders die Tatsache, daß das hämopoetische Gewebe letal bestrahlter Mäuse durch die Transplantation einer einzigen Milzkolonie (CFU-S) völlig repopuliert werden konnte (1). Derartige Zellkolonien in der Milz bestehen, wie man zeigen konnte, aus den Nachkommen einer einzigen hämopoetischen Stammzelle (2). Bis vor kurzem waren die morphologischen Eigenschaften der HSC unbekannt, vor allem deshalb, weil sie in geringer Zahl im Knochenmark vorkommt (0,2 – 0,4% der Knochenmarkzellen).

Ein Teil der Arbeit wurde mit Unterstützung von EURATOM durchgeführt (Kontraktnummer 088-72-1 BIAC)

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Authors and Affiliations

  1. Radiobiologisches Institut TNO, Rijswijk, Z.H., Niederlande

    K. A. Dicke, B. Löwenberg & D. W. van Bekkum

  2. Innere Klinik (Tumorforschung), Universitätsklinikum Essen, W.Deutschland

    U. W. Schaefer

Authors
  1. K. A. Dicke
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  2. B. Löwenberg
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  3. U. W. Schaefer
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  4. D. W. van Bekkum
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© 1975 J. F. Lehmanns Verlag München

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Dicke, K.A., Löwenberg, B., Schaefer, U.W., van Bekkum, D.W. (1975). Allogene Knochenmarktransplantation Beim Menschen. In: Knochenmark-Insuffizienz. Hämatologie und Bluttransfusion, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95871-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-95871-7_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-79776-0

  • Online ISBN: 978-3-642-95871-7

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