The ontogeny of cerebral metabolism

  • H. T. Chugani


The development of functional neuroimaging techniques has enabled energy metabolism in the developing human brain to be studied noninvasively. This can be accomplished using positron emission tomography (PET) and the principles underlying the 14C-2-deoxyglucose autoradiographic method developed by Sokoloff et al. (1977). With PET and the tracer 2-deoxy-2(l8F)fluoro-D-glucose (FDG), measurements of regional cerebral glucose utilisation can be made during different stages of development and related to behavioural maturation, synapto-genesis, plasticity and other neuromaturational phenomena.


Frontal Cortex Cerebral Metabolism Cerebral Glucose Metabolism Cerebral Glucose Utilization Synapse Elimination 
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© Springer-Verlag Berlin Heidelberg 1998

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  • H. T. Chugani

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