Craniofacial tumours and pseudotumours

  • André Mazabraud


µTwo special features of the bony tissue of the craniofacial skeleton impart a specific nature to tumours and pseudotumours at this site. There are the embryological origin of these bones, which for the most part are membrane bones derived from neuromesenchyme, and the presence in the jaws of dental rudiments as the source of specific lesions. The lesions whose special characteristics have been mentioned in the previous chapters will form the subject of only a short review of essential concepts in a craniofacial context.


Fibrous Dysplasia Osteoid Osteoma Epidermoid Cyst Primary Osteogenic Sarcoma Massive Osteolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


Craniofacial tumours and pseudotumours unconnected with the dental organ

  1. Idiopathic osteolysis (cf Chapter 26)Google Scholar
  2. Bullough PG, Goodfellow JW (1976) Solitary Iymphangioma of bone. J Bone Joint Surg (Am) 58: 418Google Scholar
  3. Frederiksen NL, Wesley RK, Sciubba JJ, Helfrick J (1983) Massive osteolysis of the maxillotacial skeleton: a clinical, radiographic, histologic and ultrastructural study. Oral Surg Oral Med Oral Pathol 55: 470–480PubMedCrossRefGoogle Scholar
  4. Heffez L, Doku HC, Carter BL, Freeney JE (1983) Perspeectives on massive osteolysis: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol 55: 331–343PubMedCrossRefGoogle Scholar
  5. Imbert JC, Picault C (1974) Ostéolyse massive idiopathique ou maladie de Jacksson-Gorham. A propos d’une nouvelle observation. Rev Chir Orthop 60: 73–80PubMedGoogle Scholar
  6. Jumbelic M, Feverstein IM, Dorfman HD (1984) Solitary intra-osseous Iymphangioma. J Bone Joint Surg 66A: 1479–1481PubMedGoogle Scholar
  7. Murphy JB, Doku HC, Carter BL (1978) Massive osteolysis: phantom bone disease. J Oral Surgery 36: 318–322Google Scholar
  8. Quaraishi MS, Blayney AW, Walker D, Breatnach FB, Bradley PJ (1995) Langerhans’cell histiocytosis: Head and neck manifestations in children. Head & Neck 17: 226–231CrossRefGoogle Scholar
  9. Thomas CB, Kveton JF, Poe DS, Zamani AA, Tarlov EC (1993) Aggressive papillary tumor of temporal bone in von HippelLindau disease. Surg Pathol 5: 63–71Google Scholar
  10. Van Den Houten BR, Ten Kate LP, Gerding JC (1985) The Hajdu-Cheney syndrome. A review of the literature and report of 3 cases. Int J Oral Surg 14: 113–125PubMedCrossRefGoogle Scholar
  11. White AA (1971) Disappearing bone disease with arthropathy and severe scarring of the skin. A report of four cases seen in South Vietnam. J Bone Joint Surg 53B: 303–309Google Scholar

Osteosarcoma (cf Chapter n) Osteoma (cf Chapter 11)

  1. Bataini JP, Chavanne G, Brugère J, Mazabraud A (1979) Radiocancers maxillo-faciaux. Rev Stomalol Chir Maxillofac 80: 178–182Google Scholar
  2. Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A (1991) The Istituto Rizzoli-Beretta experience with osteosarcoma of the jaw. Cancer 68: 1555–1563PubMedCrossRefGoogle Scholar
  3. Blodi FC (1976) Pathologic changes of the orbital bones. Am Acad Ophthalmol Otolaryngol Jan-Feb, pp 26–57Google Scholar
  4. Brocheriou C, Guilbert F, Rouchon C, Benoist M, Chikhani P (1974) Sarcomes d’Ewing localisation mandibulaire, deux observations. Rev Stanotol 75: 877 – 884Google Scholar
  5. Brocheriou C, Guilbert F, Rouchon C, Benoist M, Chikhani P (1974) Sarcomes d’Ewing à localisation mandibulaire, deux observations. Rev Stanotol 75: 877–884Google Scholar
  6. Cernéa P, Payen J, Brochériou CL (1974) Sarcomes osseux des maxillaires. Etude statistique de 41 observations. Bull Cancer 61: 151–160PubMedGoogle Scholar
  7. Chan CW, Kung TM, Ma AL (1986) Telangiectatic osteosarcoma of the mandible. Cancer 58: 2110–2115PubMedCrossRefGoogle Scholar
  8. Chomette G, Auriol M (1986) Histopathologie buccale et cervico-faciale. Ostéome, pp 262–263Google Scholar
  9. Clark JL, Unni KK, Dahlin DC, Devine KD (1983) Osteosarcoma of the jaw. Cancer 51: 2311–2316PubMedCrossRefGoogle Scholar
  10. Dahlin DC, Unni KK (1986) Bone tumors general aspects and data on 8542 cases. 4th edn. Charles Thomas, Springfield p 84Google Scholar
  11. Earwaker J (1993) Paranasal sinus osteomas a review of 46 cases. Skeletal Radiol 22: 417–423PubMedCrossRefGoogle Scholar
  12. Goodman MA, McMaster JH (1976) Primary osteosarcoma of the skull. Clin Orthop 120: 110–114PubMedGoogle Scholar
  13. Hendee RW (1976) Primary osteogenic sarcoma of the cal-varia. J Neurosurg 45: 334–337PubMedCrossRefGoogle Scholar
  14. Hilpert PL, Radecki PD, Edmonds P, Friedman AC (1986) Primary leiomyosarcoma (LMS) of the mandible. Case report. Skeletal Radiol 15: 570–574Google Scholar
  15. Huvos AG, Sundaresan N, Bretsky SS, Butler A (1985) Osteogenic sarcoma of the skull. A clinicopathologic study of 19 patients. Cancer 56: 1214–1221PubMedCrossRefGoogle Scholar
  16. Lee YY, Tassel PV, Nauert C, Raymond AK, Edeiken J (1988) Craniofacial osteosarcomas: plain film, CT, and MR findings in 46 cases. AJNR 9: 379–385Google Scholar
  17. Marks MP, Marks SC, Segall HD, Schwinn CP, Forrester DM (1987) Parosteal osteosarcoma (case report). Skeletal Radiol 16: 246–251PubMedCrossRefGoogle Scholar
  18. Millar BG, Browne RM, Flood TR (1990) Juxtacortical osteosarcoma of the jaws. Br J Oral Surg 28: 73–79CrossRefGoogle Scholar
  19. Sagerman RH, Cassady JR, Tretter P, Ellswoth RH (1969) Radiation induced neoplasia following external form therapy for children with retinoblastoma. Am J Roentgenol l05: 529–535Google Scholar
  20. Salvati M, Ciappeta P, Raco A (1992) Osteosarcoma of the skull. Cancer 71: 2210–2216CrossRefGoogle Scholar
  21. Sundaresan N, Galicich JH, Rosen H, Huvos AG (1985) Primary osteogenic sarcoma of the skull. Five-year disease-free survival following surgery and high dose methotrexate therapy. NY State J Med 85: 598–599Google Scholar
  22. Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG (1992) Sarcoma of the head and neck. Cancer 70: 169–177PubMedCrossRefGoogle Scholar

Cartilaginous tumours and pseudotumours (cf Chapters 2 and 20)

  1. Bertoni F, Unni KK, Beabout JW, Harner SG, Dahlin DC (1987) Chondroblastoma of the skull and facial bones. Am J Pathol 88: 1–9Google Scholar
  2. Boorstein JM, Spizamy DL (1988) Chondrosarcoma of base of skull (CBS). Skeletal Radio 117: 208–211CrossRefGoogle Scholar
  3. Brochériou C, Payen J (1975) Tumeurs cartilagineuses des maxillaires: à propos de n observations. Ann Anat Pathol 20: 23–34Google Scholar
  4. Coltrera MD, Gonge PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML (1986) Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature. Cancer 58: 2689–2696PubMedCrossRefGoogle Scholar
  5. Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone. Cancer 40: 818–831PubMedCrossRefGoogle Scholar
  6. Fu YS, Perzin KH (1974) Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. Cancer 34: 453–463PubMedCrossRefGoogle Scholar
  7. Garrington GE, Collett WK (1988) Chondrosarcoma. I. A selected literature review. II. Chondrosarcoma of the jaw: analysis of 37 cases. J Oral Pathol 17: 1–20PubMedCrossRefGoogle Scholar
  8. Gay I, Elidan J, Kopolovic J (1981) Chondrosarcoma at the skull base. Ann Otol Rhinol Laryngol 90: 53–55PubMedGoogle Scholar
  9. Hackney FL, Aragon SB, Aufdemorte TB, Holt GR, Van Sickels JE (1991) Chondrosarcoma of the jaws: clinical findings, histopathology, and treatment. Oral Surg Oral Med Oral Pathol 71: 139–143PubMedCrossRefGoogle Scholar
  10. Heffelfinger MJ, Dahlin DC, McCarty CS, Beabout JW (1973) Chordomas and cartilaginous tumors at the skull base. Cancer 32: 410–419PubMedCrossRefGoogle Scholar
  11. Korbi S, Kochtali K, Mokni M, Ladeb F, Kraiem C, Hamza F, Bakir A, Bouzakoura C (1991) Le chondrosarcome de la mandibule. Etude anatomoclinique d’un cas. Ann Pathol 11: 113–116PubMedGoogle Scholar
  12. Massarelli G, Gandolfo L, Tanda F, Ghiselli F, Manunta V (1988) Maxillary chondrosarcoma (report of two cases). J Laryngol Otol 102: 177–181PubMedCrossRefGoogle Scholar
  13. Sen CN, Sekhar LN, Schramm VL, Janecka IP (1989) Chordoma and chondrosarcoma of the cranial base: an 8-year experience. Neurosurg 25: 931–941CrossRefGoogle Scholar

“Fibroblastic” tumours and pseudotumours (cf Chapter 16)

  1. Abdul-Karim FW, Ayala AG, Chawla SP, Jing BS, Goeffert H (1985) Malignant fibrous histiocytoma of jaws. A clinico-pathologic study of n cases. Cancer 56: 1590–1596PubMedCrossRefGoogle Scholar
  2. Akai M, Ohno T, Sugano I, Matsuzaki O, Nagao K, Takigawa K (1990) Malignant fibrous histiocytoma of skull and face presenting with massive osteolysis. Skeletal Radiol 19: 154–157PubMedCrossRefGoogle Scholar
  3. Crisi G, Calo M, Mauri C (1986) Desmoid tumor of the greater wing of the right sphenoid bone. Skeletal Radiol 15: 247–250PubMedCrossRefGoogle Scholar
  4. Deroma PJ, Visot A (1983) La dysplasie fibreuse crânienne. Neurochirurgie 29 (suppl I): 1–117Google Scholar
  5. Earwaker J (1993) Paranasal sinus osteomas: a review of 46 cases. Skeletal Radiol 22: 417–423Google Scholar
  6. Ford KB, Palmer PES, Teslu KH (1985) Fibrous dysplasia of calvaria (multiple sclerotic lesions). Skeletal Radio 113: 68–71CrossRefGoogle Scholar
  7. Mascrés C, Vauclair R (1989) Le fibrome desmoïde maxillomandibulaire. Synthèse des connaissances sur une entité rare. A propos de trois cas. Ann Pathol 9: 182–188PubMedGoogle Scholar
  8. Remagen W, Nidecker A, Prein J (1986) Gigantic benign fibrous histiocytoma (nonossifying fibroma). Skeletal Radiol 15: 251–253PubMedCrossRefGoogle Scholar
  9. Schamaman A, Smith I, Ackerman LV (1970) Benign fibroosseous lesions of the mandible and maxilla a review of 35 cases. Cancer 26: 303–312CrossRefGoogle Scholar
  10. Schultz E, Hermann G, Irwin GAL, Shih H (1986) Desmoplastic fibroma of the mandible. Skeletal Radio 115: 560–564CrossRefGoogle Scholar
  11. Sherman NH, Rao VM, Brennam RE, Edeiken J (1982) Fibrous dysplasia of the facial bones and mandible. Skeletal Radiol 8: 141–143PubMedCrossRefGoogle Scholar

Giant-cell tuour (cf Chapter 21)

  1. Bertoni F, Unni KK, Beabout JW, Ebersold MJ (1992) Giant cell tumor of the skull. Cancer 70: 1124–1132PubMedCrossRefGoogle Scholar
  2. Chomette G, Auriol M, Tranbaloc P, Vaillant JM (1980) Contribution à l’histogenèse des tumeurs à cellules géantes des os. Etude comparative, ultrastructurale et histo-enzymologique de tumeurs ostéoformatrices et de tumeurs à cellules géantes et malignes. Ann Anat Pathol (Paris) 25: 231–243Google Scholar
  3. Flanagan AM, Nui B, Tinkler SMB, Horton A, Williams DM, Chambers TJ (1988) The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer 62: 1139–1145PubMedCrossRefGoogle Scholar
  4. Harman SA, Pribram H (1990) Giant cell tumor of sphenoid bone. Skeletal Radiol 19: 212–215PubMedCrossRefGoogle Scholar
  5. Maroteaux (1982) Maladies osseuses de l’enfant chérubisme. Flammarion Médecine-Sciences, Paris, pp 123–124Google Scholar
  6. Rogers LF, Mikhael M, Christ M, Wolff A (1984) Giant-cell (reparative) granuloma of the sphenoid bone. Skeletal Radiol 12: 48–53PubMedCrossRefGoogle Scholar
  7. Wolfe JT, Schetthauer BW, Dahlin DC (1983) Giant-cell tumor of the sphenoid bone. Review of 10 cases. J Neurosurg 59: 322–327PubMedCrossRefGoogle Scholar

Melanotic progonoma

  1. Atkinson GJ, Davis PC, Patrick LE, Winn KJ, Ball TI, Wyly JB (1989) Melanotic neuroectodermal tumor of infancy. MR findings and a review of the literature. Pediatr Radiol 20: 20–22Google Scholar
  2. Bignold LP, Nicks R (1980) Melanotic neuroectodermal tumour of infancy arising in anterior fontanelle. Pathology 12: 473–477PubMedCrossRefGoogle Scholar
  3. Carlier G, Donazzan M, Vandenbussche F, Gosselin B (1974) The neurocristopathies. A unifying concept of disease arising in neural creast maldevelopment. Hum Pathol 5: 409–429CrossRefGoogle Scholar
  4. Causeret M, Saint-André JP, Cerez-Pham H, Rousselet MC, Guy G, Simard CP (1987) Progonome mélanotique intra-crânien. Rapport d’un cas avec une étude immunohistochimique et ultrastructurale. Arch Anat Cytol Pathol 35: 45–48PubMedGoogle Scholar
  5. Cutler LS, Chaudhry AP, Topazian R (1981) Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. Cancer 48: 257–270PubMedCrossRefGoogle Scholar
  6. Dechaume M, Cauhepe J, Payen J, Peri G (1966) A propos d’un cas de mélanotic progonome. Rev Stomatol 67: 321–327Google Scholar
  7. Johnson RE, Scheithauer BW, Dahlin DC (1983) Melanotic neuroectodermal tumor of infancy. A review of seven cases. Cancer 52: 661–666PubMedCrossRefGoogle Scholar
  8. Jones HH, Parker BR, Ballerio CG, Silverman FN, Kempson RL (1990) Melanotic neuroectodermal tumor of infancy (melanotic progonoma) involving the calvaria. Skeletal Radio 119: 527–530Google Scholar
  9. Kuhn R, Cabanne F, Garneau R (1954) Le rtinoblastome pigmentaire htrotopique. Sem Hop Paris 30: 178–185Google Scholar
  10. Lamping KA, Albert DM, Lack E, Dickersin GR, Chapman PH, Walton DS (1985) Melanotic neuroectodermal tumor of infancy (retinal anlage tumor). Ophthalmology 92: 143–149PubMedGoogle Scholar
  11. Le Douarin N, Teillet MA (1973) Recherches sur le déterminisme de la migration des cellules issues de la crête neurale. CR Acad Sci Paris 277: 1929–1932Google Scholar
  12. Melano-ameloblastoma, retinal anlage tumor, melanotic neuroectodermal tumor of infancy. A propos d’un cas. Revue de la littérature. Thèse de doctorat en médecine n° 9 février 1984, Patrick Chenet, Université de ClermontFerrand-IGoogle Scholar
  13. Mugnier A, Bordais P, Croisier N (1974) Tumeur pigmentée du maxillaire supérieur chez l’enfant. Rev Stomatol Paris 75: 771–782Google Scholar
  14. Navas Palacios JJ (1980) Malignant melanotic neuroectodermal tumor: light and electron microscopic study (Eng). Cancer 146: 529–536Google Scholar

Odontogenic tumours and pseudotumours

  1. Ackerman GL, Altini M, Shear M (1988) The unicystic ameloblastoma: a clinicopathological study of 57 cases. J Oral Pathol 17: 541–546CrossRefGoogle Scholar
  2. Ashman SG, Goria RL, Eisele DW, Murphy MT (1993) Desmoplastic ameloblastoma. A case report and literature review. Oral Surg Oral Med Oral Pathol 75: 479–482PubMedCrossRefGoogle Scholar
  3. Aufdermaur M (1981) Pindborg tumor. J Cancer Res Clin Oncol l01: 227–230CrossRefGoogle Scholar
  4. Brochériou C, Roquancourt (de) A (1987) Anatomie pathologique dentaire et stomatologique. Editions CdP, Paris, p 58Google Scholar
  5. Browne RM, Cough NG (1972) Malignant change in the epi- thelium lining odontogenic cysts. Cancer 29: 1199–1207PubMedCrossRefGoogle Scholar
  6. Cernéa P, Kuffer R, Baumont M, Brochériou C Guilbert F (1969) Naevomatose baso-cellulaire. Association de nævi baso-cellulaire de la peau, de kystes épidermoïdes des maxillaires, de malformations osseuses et d’autres anomalies; 7 observations. Rev Stomatol Chir Maxillofac 70: 181–226PubMedGoogle Scholar
  7. Chomette G, Auriol M (1986) Histopathologie buccale et cervico-faciale. Masson, Paris, pp 58–62Google Scholar
  8. Crawley WA, Levin LS (1978) Treatment of the ameloblastoma. A controversy. Cancer 42: 357–363PubMedCrossRefGoogle Scholar
  9. Dorner L, Sear AJ, Smith GT (1988) A case of ameloblastic carcinoma with pulmonary metastases. Br J Oral Maxillofac Surg 26: 503–510PubMedCrossRefGoogle Scholar
  10. Eversole LR, Leider AS, Hansen LS (1984) Ameloblastomas with pronounced desmoplasia. J Oral Maxillofac Surg 42: 735–740PubMedCrossRefGoogle Scholar
  11. Gardner DG (1977) Peripheral ameloblastoma. A study of 21 cases, including 5 reported as basal cell carcinoma of the gingiva. Cancer 39: 1625–1633PubMedCrossRefGoogle Scholar
  12. Goldstein G, Parker FP, Slaughter Fitz Hugh G (1976) Ameloblastic sarcoma. pathogenesis and treatment with chemotherapy. Cancer 37: 1673–1678PubMedCrossRefGoogle Scholar
  13. Gordeeff M (1987) Etude des kystes odontogènes des maxillaires. Thèse diplome d’état de docteur en chirurgie dentaire. Université de NantesGoogle Scholar
  14. Gordeeff M,-Clergeau-Guerithault S, Gordeeff A (1989) L’histopathologie des kystes odontogènes. J Biol Buccale 17: 131–145Google Scholar
  15. Hammer JE, Scofield H, Cornyn J (1968) Benign fibro-osseous jaw lesions of periodontal membrane origin. An analysis of 249 cases. Cancer 22: 861–878CrossRefGoogle Scholar
  16. Hodgkinson DG, Woods JE, Dahlin DC, Tolman DE (1978) Keratocysts of the jaw. Clinicopathology study of 79 patients. Cancer 41: 803–813PubMedCrossRefGoogle Scholar
  17. Maroteaux P (1982) Maladies osseuses de l’enfant. Flammarion Médecine-Sciences, Paris, pp 433–434Google Scholar
  18. Navarette VR, Smith M (1971) Ultrastructure of granular cell ameloblastoma. Cancer 27: 948–955CrossRefGoogle Scholar
  19. Odukoya O, Arole O (1992) Clear-cell ameloblastoma of the mandible (a case report). Int J Oral Maxillofac Surg 21: 358–359PubMedCrossRefGoogle Scholar
  20. Page DL, Weiss SW, Eggleston JC (1975) Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumor. Cancer 36: 1426–1435PubMedCrossRefGoogle Scholar
  21. Pindborg JJ (1958) A calcifying epithelial odontogenic tumor. Cancer 11: 838–843PubMedCrossRefGoogle Scholar
  22. Sehdev MK, Huvos AG, Strong EW, Gerold FP, Willis GW (1974) Ameloblastoma of maxilla and mandible. Cancer 33: 324–333PubMedCrossRefGoogle Scholar
  23. Seward GR, Beales SJ, Johnson NW, Lumsden S (1975) A metastasising ameloblastoma associated with renal calculi and hyperealeaemia. Cancer 36: 2277–2285PubMedCrossRefGoogle Scholar
  24. Siar C, Ng N, Jalil N (1991) Plexiform granular cell odontogenic tumors: unicystic variant. Oral Surg Oral Med Oral Pathol 72: 82–85PubMedCrossRefGoogle Scholar
  25. Tamimoto K, Takata T, Suei Y, Wada T, (1991) A case of desmoplastic variant of a mandibular ameloblastoma. J Oral Maxillofac Surg 49: 94–97CrossRefGoogle Scholar
  26. Vap DR, Dahlin DC, Turlington EG (1970) Pindborg tumor: the so-called calcifying epithelial odontogenic tumor. Cancer 25: 629–636PubMedCrossRefGoogle Scholar
  27. Waldrom CA, El-Mofty SK (1987) A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant. Oral Surg Oral Med Oral Pathol 63: 441–451CrossRefGoogle Scholar
  28. Yamamoto G, Yoshitake K, Tada K, Yoshida K, Yokota H, Fukuda Y, Ishida T (1989) Granular cell ameloblastoma. A rare variant. Int J Oral Maxillofac Surg 18: 140–141PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • André Mazabraud
    • 1
  1. 1.Institut CurieParis Centre de PathologieBièvresFrance

Personalised recommendations