• André Mazabraud


The pathological and clinical variants of this tumour have given rise to debates of a nosologic, pathogenic and therapeutic nature; a debate which will doubtless lead to a better understanding of these lesions and more adequate treatment programs. There seems to be every degree of aggression in this type of lesion. At the two extremes, there are the slowly-growing and possibly curable forms (histiocytoid or epithelioid haemangioendothelioma, myxoid haemangioendothelioma); at the other extreme are the forms which are rapidly fatal despite mutilating surgical procedures and chemotherapy (anaplastic, sarcomatous form). Between these two forms there are types whose lethal course extends over 1 to 5 years. Although classification into histological grades of malignancy does not provide a precise prediction of the course of the lesion its application to haemangioendotheliomas is generally perfectly legitimate.


Osteoid Osteoma Hereditary Hemorrhagic Telangiectasia Epithelioid Hemangioendothelioma Myxoid Chondrosarcoma Sarcomatous Form 
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  1. Abrahams TG, Bula W, Jones M (1992) Epithelioid heman-gioendothelioma of bone. A report of two cases and review of the literature. Skeletal Radiol 21: 509–513Google Scholar
  2. Angervall L, Kindblom LG, Karlsson K, Stener B (1985) Atypical hemangioendothelioma of venous origin. A cli-nicopathologic, angiographic, immunohistochemical and ultrastructural study of two endothelial tumors within the concept of histiocytoid hemangioma. Am J Surg Pathol 9: 504–516Google Scholar
  3. Boccara M, Foucault D, Dumesnil de Maricourt, Gerbai JL, Mazabraud A, Quillard J, Manigand G, Deparis M (1978) L’hémangioendothéliome des os. A propos d’une observa-tion anatomoclinique. Sem Hop Paris 54: 1278–1282Google Scholar
  4. Boyle WJ (1972) Cystic angiomatosis of bone. A report of three cases and review of the literature. J Bone Joint Surg 54B: 626–636Google Scholar
  5. Bundens WD, Brighton CT (1965) Malignant hemangioen-dothelioma of bone. Report of two cases and review of the literature. J Bone Joint Surg 47A: 762–772Google Scholar
  6. Campanacci M, Boriani S, Ginnti A (1980) Hemangio endothelioma of bone: a study of 29 cases. Cancer 46: 804–814PubMedCrossRefGoogle Scholar
  7. Cayla J, Roger M, Rondier J, Guiraudon C, Malherbe M, Grellet J (1977) Les hémangioendothéliomes malins osseux. A pro-pos d’un cas. Rev Rhum 44: 354–358Google Scholar
  8. Chow RW, Wilson CF, Olsen ER (1970) Angiosarcoma of the skull. Report of a case and review of the literature. Cancer 25: 902–906Google Scholar
  9. Cone RO, Hudkins P, Nguyen V, Merriwether WA (1983) Histiocytoid hemangioma of bone: a benign lesion which may mimic angiosarcoma. Skeletal Radiol 10: 165–169PubMedCrossRefGoogle Scholar
  10. Corrin B, Manners B, Millard M, Weaver L (1979) Histogenesis of the so-called “intravascular bronchioloalveolar tumor”. J Pathol 128: 163–167PubMedCrossRefGoogle Scholar
  11. Costello SA, Sdeywright M (1990) Postirradiation malignant transformation in benign hemangioma. European J Surg Oncol 16: 517–519Google Scholar
  12. Craver WL, Brown BS (1979) Hemangioendothelioma of bone with pulmonary metastases: a 25 year course. Report of a case. Cancer 43: 1917–1923Google Scholar
  13. Dail DH, Liebow AA (1975) Intravascular bronchioloalveo-lar tumor. Am J Pathol 78: 6aGoogle Scholar
  14. Desproges-Gotteron R, Dunoyer J, Loubet R, Rousseau J, Claude M, Leroy V (1972) A propos d’un cas d’angiomatose diffuse et extensive du squelette. Rev Rhum 39: 306–311PubMedGoogle Scholar
  15. Dube VE, Fischer DE (1972) Hemangioendothelioma of the leg following metallic fixation of the tibia. Cancer 30: 1260–1266PubMedCrossRefGoogle Scholar
  16. Garcia-Moral CA (1972) Malignant hemangioendothelioma of bone. Review of world literature and report of two cases. Clin Orthop 82: 70–79PubMedGoogle Scholar
  17. Gilbert EF, Jones B, Majzoub HS (1971) Malignant heman-gioendothelioma of bone in childhood. A report of a case and review of the literature. Am J Dis Child 121: 410–414Google Scholar
  18. Gutierrez RM, Spjut HL (1972) Skeletal angiomatosis: report of three cases and review of the literature. Clin Orthop 85: 82–97PubMedCrossRefGoogle Scholar
  19. Hartmann WH, Stewart FW (1962) Hemangioendothelioma of bone. Cancer 15: 846–854PubMedCrossRefGoogle Scholar
  20. Himmer O, Lootvoet L, Deprez P, Monfor L, Ghosez JP (1991) Angiosarcome après prothèse totale du genou. Rev Chir Orthop 77: 125–129PubMedGoogle Scholar
  21. Jaffe JW, Mesgarzadeh M, Bonakdarpour A, Edmonds PR (1989) Histiocytoid hemangioendothelioma of right loth rib. Skeletal Radiol 18: 50–54PubMedCrossRefGoogle Scholar
  22. Jennings TA, Peterson L, Axiotis CA, Friedlaender GE, Cooke RA, Rosai J (1988) Angiosarcoma associated with foreign body material. A report of three cases. Cancer 62: 24362444Google Scholar
  23. Kaufmann S, Stout AP (1961) Malignant hemangioendothe-lioma in infants and children. Cancer 14: 1186–1196CrossRefGoogle Scholar
  24. Larson SV, Lorentzon B, Boquist L (1975) Malignant heman gioendothelioma of bone. J Bone Joint Surg 57A: 84–89Google Scholar
  25. Leader M, Collins M, Patel J, Henry K (1986) Staining for fac-tor VIII related antigen and ulex europaeus agglutinin I (UEA-I) in 230 tumours. An assessment of their specific-ity for angiosarcoma and Kaposi s sarcoma. Histopathology to: 1153–1162Google Scholar
  26. Martinez-Tello FJ, Marco-Robles J, Blanco-Lorenzo F (1989) Primary epithelioid hemangioendothelioma of bone (poly-ostotic). Skeletal Radio118: 55–59Google Scholar
  27. Maruyama N, Kumagai Y, Ishida Y (1985) Epithelioid heman-gioendothelioma of the bone tissue. Virchows Arch (A) 407: 159–165CrossRefGoogle Scholar
  28. Miettinen M, Holthofer H, Lehto VP, Miettinen A, VirtanenGoogle Scholar
  29. I (1983) Ulex europaeus I lectin as a marker for tumors derived from endothelial cells. Am J Clin Pathol 79: 32–36Google Scholar
  30. Mirra JM, Arnold WD (1973) Skeletal hemangiomatosis in association with hereditary hemorrhagic telangiectasia. J Bone Joint Surg 55A: 850–854PubMedGoogle Scholar
  31. Mirra JM, Kameda N (1985) Myxoid angioblastomatosis of bones. A case report of a rare, multifocal entity with light, ultramicroscopic, and immunopathologic correlation. AmGoogle Scholar
  32. J Surg Pathol 9: 450–458 Morgenstern P, Westing SW (1969) Malignant hemangioen-dothelioma of bone. Fourteen-year follow-up in a case treated with radiation alone. Cancer 23: 221–224Google Scholar
  33. Mukai K, Rosai J, Burgdorf WC (1980) Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxidase method. Am J Surg Pathol 4: 273–276PubMedCrossRefGoogle Scholar
  34. Ose D, Vollmer R, Shelburne J, McComb R, Harrelson J (1983) Histiocytoid hemangioma of the skin and scapula. A case report with electron microscopy and immunohistochem-istry. Cancer 51: 1656–1662Google Scholar
  35. Otis J, Hutter RWP, Foote FW, Marcove RC, Stewart FW (1968) Hemangioendothelioma of bone. Surg Gynecol Obstet 127: 295–305PubMedGoogle Scholar
  36. Pollak A (1949) Angiosarcoma of the sternum. Am J Surg 77: 522–527PubMedCrossRefGoogle Scholar
  37. Reed R (1982) Consultation case: malignant angioblastoma of bone. Am J Surg Pathol 6: 159–163PubMedCrossRefGoogle Scholar
  38. Rosai J, Gold J, Landy R (1979) The histiocytoid hemangio-mas. A unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone and heart. Hum Pathol 10: 707–730Google Scholar
  39. Schajowicz F, Rebecchini AC, Bosch-Mayol G (1979) Intracortical hemangioma simulating osteoid osteoma. J Bone Joint Surg 61B: 94–95Google Scholar
  40. Smet (de) AA, Debra I, Neff JR (1989) Histiocytoid heman-gioma of the distal end of the right humerus. Skeletal Radiol 18: 60–65CrossRefGoogle Scholar
  41. Steiner GC, Dorfman HD (1972) Ultrastructure of heman-gioendothelial sarcoma of bone. Cancer 29: 122–135PubMedCrossRefGoogle Scholar
  42. Stout AP (1943) Hemangioendothelioma: a tumor of blood vessels featuring vascular endothelial cells. Ann Surg 118: 445–464PubMedCrossRefGoogle Scholar
  43. Sweterlitsch PR, Torg JS, Watts H (1970) Malignant heman-gioendothelioma of the cervical spine a case report. J Bone Joint Surg 52A: 805–808PubMedGoogle Scholar
  44. Tsuneyoshi M, Dorfman HD, Bauer TW (1986) Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultra-structural and immunohistochemical study. Am J Surg Pathol 10: 754–764Google Scholar
  45. Volpe R, Mazabraud A (1982) Hemangioendothelioma (angio-sarcoma) of bone: a distinct pathologic entity with an unpredictable course? Cancer 49: 727–736PubMedCrossRefGoogle Scholar
  46. Weiss SW, Enzinger FM (1982) Epithelioid hemangioendoth-elioma. A vascular tumor often mistaken for a carcinoma. Cancer 50: 970–981Google Scholar
  47. Wold LE, Unni KK, Beabout JW, Ivins JC, Bruckman JE, Dahlin DC (1982) Hemangioendothelial sarcoma of bone. Am J Surg Pathol 6: 59–70PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • André Mazabraud
    • 1
  1. 1.Institut CurieParis Centre de PathologieBièvresFrance

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