Nimodipine is a Ca2+ antagonist of the 1,4-dihydropyridine type that specifically blocks the L-type Ca2+ channel by reducing its opening probability. Binding sites for nimodipine are distinctly located in the central nervous system (CNS), especially in the hippocampal formation and the cortex. These brain structures play an important role in the regulation of cognitive processes. Nimodipine acts not only on neurons but also on glial cells (Hertz et al. 1989). This finding may be highly relevant for nimodipine’s action, given the fact that 50% of the cells in the CNS consist of glial cells which support and modulate the function of neurones in the CNS. Finally, there are binding sites for nimodipine on CNS blood vessels which thus provide another target for the drug.
KeywordsPlacebo Depression Ischemia Dementia Morphine
Unable to display preview. Download preview PDF.
- de Jong GI, de Weerd H, Schuurman T, Traber J, Luiten PGM (1990) Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment. Neurobiol Aging 11:381–389Google Scholar
- de Jong GI, Nyakas C, Schuurman T, Luiten PGM (1992) Aging-related alterations in behavioral activation and cerebrovascular integrity in rats are dose-dependently influenced by nimodipine. Neurosci Res Commun 12:1–8Google Scholar
- Gispen WH, Schuurman T, Traber J (1988) Nimodipine and neural plasticity in the peripheral nervous system of adult and aged rats. In: Morad M, Nayler W, Kazda S, Schramm M (eds) The calcium channel: structure, function and implications. Springer, Berlin Heidelberg New York, pp 491–502CrossRefGoogle Scholar
- Kappelle AC, Bravenboer B, Traber J, Erkelens DW, Gispen WH (1992) The Ca2+ antagonist nimodipine counteracts the onset of an experimental neuropathy in streptozotocin induced, diabetic rats. Neurosci Res Commun 10:95–104Google Scholar
- Khatchaturian ZS (1989) The role of calcium regulation in brain aging: reexamination of a hypothesis. Aging 1:17–34Google Scholar
- Ritz M, George FR, Meisch RA (1989) Ethanol self-administration in ALKO rats: I. Effects of selection and concentration. Alcohol 6:227–233Google Scholar
- Schuurman T, Traber J (1989a) Old rats as an animal model for senile dementia: behavioral effects of nimodipine. In: Bergener M, Reisberg B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York, pp 295-307Google Scholar
- Schuurman T, Traber J (1989b) Effects of nimodipine on behavior of old rats. In: Traber J, Gispen WH (eds) Nimodipine and central nervous system function: new vistas. Schattauer, Stuttgart, pp 195–208Google Scholar
- Schuurman T, Klein H, Beneke M, Traber J (1987) Nimodipine and motor deficits in aged rats. Neurosci Res Commun 1:9–15Google Scholar
- Uematsu D, Greenberg JH, Hickey WF, Reivich M (1989) Nimodipine attenuates both increase in cytosolic free calcium and histologic damage following focal cerebral ischemia and reperfusion in cats. Stroke 20:1531-1537 van der Zee CEEM, Schuurman T, Traber J, Gispen WH (1987) Oral administration of nimodipine accelerates functional recovery following peripheral nerve damage in the rat. Neurosci Lett 83:143–148Google Scholar