Nimodipine is a Ca2+ antagonist of the 1,4-dihydropyridine type that specifically blocks the L-type Ca2+ channel by reducing its opening probability. Binding sites for nimodipine are distinctly located in the central nervous system (CNS), especially in the hippocampal formation and the cortex. These brain structures play an important role in the regulation of cognitive processes. Nimodipine acts not only on neurons but also on glial cells (Hertz et al. 1989). This finding may be highly relevant for nimodipine’s action, given the fact that 50% of the cells in the CNS consist of glial cells which support and modulate the function of neurones in the CNS. Finally, there are binding sites for nimodipine on CNS blood vessels which thus provide another target for the drug.
KeywordsMiddle Cerebral Artery Occlusion Force Swimming Test Nerve Conductance Velocity Nervous System Function Acquisition Session
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