Pharmacological Classification of High-Threshold Calcium Channels in Rat Neurons
Voltage-dependent calcium channels are present in all neurons. They are closed at normal resting potentials, and they open when a membrane is depolarized by an action potential. One important function of calcium channels in neurons is to mediate release of neurotransmitter from presynaptic nerve terminals. In addition, calcium channels help initiate electrical action potentials in various cell bodies and dendrites. It is very likely that calcium entry through voltage-dependent calcium channels is also important for a whole range of phenomena triggered by increases in internal calcium levels. Among these phenomena may be cell death resulting from prolonged calcium entry subsequent to long-lasting depolarizations, as may occur during ischemia.
KeywordsCalcium Channel Purkinje Neuron Cerebellar Purkinje Neuron Calcium Channel Current Visual Cortical Neuron
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Bean BP (1984) Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci USA 81:6388–6392PubMedCrossRefGoogle Scholar
Fox AP, Nowycky MC, Tsien RW (1987) Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (Lond) 394:173–200Google Scholar
Fox AP, Nowycky MC, Tsien RW (1987) Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (Lond) 394:149–172Google Scholar
Llinas R, Sugimori M, Lin JW, Cherksey B (1989) Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc Natl Acad Sci USA 86: 1689–1693PubMedCrossRefGoogle Scholar
McCarthy R, Tanpiengco P (1992) Multiple types of high-threshold calcium channels in rabbit sensory neurons: high-affinity block of neuronal L-type by nimodipine. J Neurosci 12:2225–2234PubMedGoogle Scholar
Miller RJ (1992) Voltage sensitive Ca2+ channels. J Biol Chem 267:1403–1406PubMedGoogle Scholar
Mintz IM, Adams ME, Bean BP (1992) P-type calcium channels in central and peripheral neurons. Neuron 9:1–20CrossRefGoogle Scholar
Mintz IM, Venema VJ, Swiderek K, Lee T, Bean BP, Adams ME (1992) P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 355:827–829PubMedCrossRefGoogle Scholar
Regan LJ (1991) Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. J Neurosci 11:2259–2269PubMedGoogle Scholar
Regan LJ, Sah DW, Bean BP (1991) Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and omegaconotoxin. Neuron 6:269–280PubMedCrossRefGoogle Scholar
Tsien RW, Ellinor PT, Horne WA (1991) Molecular diversity of voltage-dependent Ca2+ channels. Trends Pharmacol Sci 12:349–354PubMedCrossRefGoogle Scholar
© Springer-Verlag Berlin Heidelberg 1993