• Gerd Bönner
  • Karl-Heinz Rahn


The regulation of systemic blood pressure is based on multiple central and peripheral regulatory mechanisms, among which the vasoactive hormonal systems play a not insignificant part. In the past it was particularly the hormonal systems with an active vasopressor effect such as the renin-angiotensin system, the mineralocorticoids, catecholamines and the antidiuretic hormone that attracted the greatest attention in hypertension research. For a long period an excessive importance was attached to the vasopressor hormones as the essential cause of arterial hypertension, but the importance of vasodepressor hormone systems such as the kallikrein-kinin system and the prostaglandins remained unappreciated for many years, and a deficiency of vasodepressor agents was seldom considered as a pathogenetic factor in the development of hypertension. This is the more surprising since the blood pressure-lowering action of the kallikrein-kinin system (the “F substance”) had been discovered by Frey and Kraut [74] as far back as 1926.


Prostaglandin Catecholamine Antidiuretic Hormone Thromboxane Prostacyclin 

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Gerd Bönner
    • 1
  • Karl-Heinz Rahn
    • 2
  1. 1.Medizinische Universitätsklinik IIStädtische Krankenanstalten MerheimKöln 91Germany
  2. 2.Medizinische PoliklinikUniversität MünsterMünsterGermany

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