Epidemiologic Measurements for the Determination of Genetic Risks
The tendency for epilepsy to aggregate in families has long been recognized While it is clear that some diseases for which seizures or epilepsy are included as part of a symptom complex will follow Mendelian patterns of inheritance, in these families the phenotypic expression of the seizures tend to be similar. Such patterns account for only a small proportion of all cases of seizure disorders. For these unique families, linkage studies and gene mapping is appropriate to determine the location of the abnormal gene. In addition, biochemical or other specialized studies are warranted to identify the underlying mechanisms by which seizures occur. Such studies may ultimately lead to clues for all cases of epilepsy.
KeywordsCumulative Incidence Febrile Seizure Seizure Type Unprovoked Seizure Mendelian Pattern
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