Abstract
Knowledge of the genetics of special electroencephalographic (EEG) patterns related to epilepsy was in the past three decades obtained from family studies of siblings of probands with epilepsy. Bilaterally synchronous generalized spike and wave (GSW) paroxysms during rest and hyperventilation [9, 12], photosensitivity [10], 4–7 rhythms [8], and focal sharp waves [5, 6] have been found to be genetically determined Suggestions about the mode of transmission of these EEG patterns have also been made. Subsequently, family EEG investigations have focused on children of epileptic patients. Scheffner [20] has critically reviewed these investigations and highlighted some important directions for further study. Although the frequency of specific EEG abnormalities has been reported in these studies, a systematic evaluation of GSW paroxysm has never been carried out. Furthermore, the clinical significance of GSW paroxysms in offspring of epileptic patients has also not been elucidated.
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Tsai, J.J., Beck-Mannagetta, G., Janz, D., Scheffner, D., Behl, I., Scholz, G. (1989). Generalized Spike and Wave Paroxysm — Subclinical Signs of Seizure Liability in Offspring of Epileptic Patients. In: Beck-Mannagetta, G., Anderson, V.E., Doose, H., Janz, D. (eds) Genetics of the Epilepsies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95553-2_17
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DOI: https://doi.org/10.1007/978-3-642-95553-2_17
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