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Genetics of the Epilepsies pp 127–136Cite as

Generalized Spike and Wave Paroxysm — Subclinical Signs of Seizure Liability in Offspring of Epileptic Patients

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Abstract

Knowledge of the genetics of special electroencephalographic (EEG) patterns related to epilepsy was in the past three decades obtained from family studies of siblings of probands with epilepsy. Bilaterally synchronous generalized spike and wave (GSW) paroxysms during rest and hyperventilation [9, 12], photosensitivity [10], 4–7 rhythms [8], and focal sharp waves [5, 6] have been found to be genetically determined Suggestions about the mode of transmission of these EEG patterns have also been made. Subsequently, family EEG investigations have focused on children of epileptic patients. Scheffner [20] has critically reviewed these investigations and highlighted some important directions for further study. Although the frequency of specific EEG abnormalities has been reported in these studies, a systematic evaluation of GSW paroxysm has never been carried out. Furthermore, the clinical significance of GSW paroxysms in offspring of epileptic patients has also not been elucidated.

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Author information

Authors and Affiliations

  1. Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan, R.O.C.

    J. J. Tsai

  2. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    G. Beck-Mannagetta, D. Janz & I. Behl

  3. Neuropädiatrische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    D. Scheffner

  4. Abteilung für Neurophysiologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    G. Scholz

Authors
  1. J. J. Tsai
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  2. G. Beck-Mannagetta
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  3. D. Janz
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  4. D. Scheffner
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  5. I. Behl
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  6. G. Scholz
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Editor information

Editors and Affiliations

  1. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Gertrud Beck-Mannagetta M.D. (Assistant Professor of Neurology) & Dieter Janz M.D. (Professor of Neurology) (Assistant Professor of Neurology) &  (Professor of Neurology)

  2. Dight Laboratories, University of Minnesota, 400 Church Street S.E., 55455, Minneapolis, MN, USA

    V. Elving Anderson M.D. (Professor of Genetics and Cell Biology) (Professor of Genetics and Cell Biology)

  3. Abteilung für Neuropädiatrie, Universität Kiel, Schwanenweg 20, D-2300, Kiel, Germany

    Hermann Doose M.D. (Professor of Pediatrics) (Professor of Pediatrics)

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© 1989 Springer-Verlag Berlin Heidelberg

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Tsai, J.J., Beck-Mannagetta, G., Janz, D., Scheffner, D., Behl, I., Scholz, G. (1989). Generalized Spike and Wave Paroxysm — Subclinical Signs of Seizure Liability in Offspring of Epileptic Patients. In: Beck-Mannagetta, G., Anderson, V.E., Doose, H., Janz, D. (eds) Genetics of the Epilepsies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95553-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-95553-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95555-6

  • Online ISBN: 978-3-642-95553-2

  • eBook Packages: Springer Book Archive

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