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Die Wirkung ionisierender Strahlen auf das Myokard

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Myokarderkrankungen Perikarderkrankungen Herztumoren

Part of the book series: Handbuch der inneren Medizin ((INNEREN 9,volume 9 / 5))

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Zusammenfassung

Bereits zwei Jahre nach der Veröffentlichung Roentgens „Über eine neue Art von Strahlen“ (1895) untersuchten Sabrazes u. Riviere (1897) die Wirkung intensiver Röntgenstrahlung auf das Froschherz und stellten keinen Effekt fest. Weitere tierexperimentelle Untersuchungen blieben (ebenso wie Mitteilungen über Strahlenveränderungen am menschlichen Herzen) bis in die frühen 60er Jahre spärlich und in ihren Ergebnissen widersprüchlich. Beobachtungen an Hunde-, Kaninchen- und Rattenherzen (Warren u. Whippel 1922; Warthin u. Pohle 1929; Leach u. Sugiura 1941) schienen den Befund von Sabrazes u. Riviere ZU bestätigen. Senderoff et al. (1960) stellten sogar eine Lebensverlängerung bei Hunden fest, deren Herzen nach Koronarligatur mit niedrigen Dosen bestrahlt worden waren. Dagegen standen Befunde von Davis (1924), der als erster radiogene Fibrösen und Blutungen des rechten Vorhofes bei Hunden und Kaninchen (und beim Menschen) beschrieb, oder von Hartmann et al. (1927) und Warthin u. Pohle (1931), die ähnliche Veränderungen an Schaf-, Hunde- und Rattenherzen nachwiesen. Jonek u. Kosmider (1963) fanden pathologische Enzymveränderungen des Herzmuskels bei bestrahlten Meerschweinchen. Solche Befunde wurden relativiert durch Berichte, nach denen Myokardnekrosen im Tierexperiment erst mit Dosen von 20 000 R auslösbar waren (Moss et al. 1963; Stone et al. 1964; Bishop et al. 1965).

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Authors
  1. J. Slanina
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Editors and Affiliations

  1. Abteilung Innere Medizin III — Kardiologie —, Medizinische Universitätsklinik, Hugstetter Str. 55, D-7800, Freiburg, Deutschland

    Hanjörg Just  & W. Kasper  & 

  2. Kardiologische Universitätsklinik, Allgemeines Krankenhaus der Stadt Wien, Garnisongasse 13, A-1097, Wien, Österreich

    F. Kaindl  & H. Zilcher  & 

  3. Luitpold-krankenhaus, Medizinische Universitätsklinik, Josef-Schneider-Str. 2, D-8700, Würzburg, Deutschland

    K. Kochsiek  & P. Schanzenbächer  & 

  4. II. Medizinische Klinik, Städtische Krankenanstalten Bielefeld-Mitte, Teutoburger Str. 50, D-4800, Bielefeld 1, Deutschland

    H. Kuhn

  5. Abteilung für Innere Medizin — Kardiologie — am Zentrum Innere Medizin, Philipps-Universität, Baidingerstraße, D-3550, Marburg, Deutschland

    B. Maisch

  6. II. Medizinische Klinik, Allgemeines Krankenhaus St. Georg, Lohmühlenstr. 5, D-2000, Hamburg 1, Deutschland

    Thomas Meinertz

  7. Zentralinstitut für Herz-Kreislauf-Forschung, Akademie der Wissenschaften der DDR, Wiltbergstr. 50, DDR-1115, Berlin-Buch, Deutschland

    H. R. Ruser

  8. Klinikum der Johannes Gutenberg-Universität, Langenbeckstr. 1, D-6500, Mainz 1, Deutschland

    Paul Schölmerich

  9. Abteilung Allgemeine Pharmakologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Deutschland

    H. Scholz

  10. Radiologische Klinik, Abteilung Strahlentherapie, Klinikum der Albert-Ludwigs-Universität, Hugstetter Str. 55, D-7800, Freiburg, Deutschland

    J. Slanina

  11. Genetische Beratungsstelle des Landes Rheinland-Pfalz, Hafenstr. 6, D-6500, Mainz 1, Deutschland

    U. Theile

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Slanina, J. (1989). Die Wirkung ionisierender Strahlen auf das Myokard. In: Just, H., et al. Myokarderkrankungen Perikarderkrankungen Herztumoren. Handbuch der inneren Medizin, vol 9 / 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95517-4_18

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  • DOI: https://doi.org/10.1007/978-3-642-95517-4_18

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