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Die Wirkung ionisierender Strahlen auf das Myokard

  • J. Slanina
Part of the Handbuch der inneren Medizin book series (INNEREN, volume 9 / 5)

Zusammenfassung

Bereits zwei Jahre nach der Veröffentlichung Roentgens „Über eine neue Art von Strahlen“ (1895) untersuchten Sabrazes u. Riviere (1897) die Wirkung intensiver Röntgenstrahlung auf das Froschherz und stellten keinen Effekt fest. Weitere tierexperimentelle Untersuchungen blieben (ebenso wie Mitteilungen über Strahlenveränderungen am menschlichen Herzen) bis in die frühen 60er Jahre spärlich und in ihren Ergebnissen widersprüchlich. Beobachtungen an Hunde-, Kaninchen- und Rattenherzen (Warren u. Whippel 1922; Warthin u. Pohle 1929; Leach u. Sugiura 1941) schienen den Befund von Sabrazes u. Riviere ZU bestätigen. Senderoff et al. (1960) stellten sogar eine Lebensverlängerung bei Hunden fest, deren Herzen nach Koronarligatur mit niedrigen Dosen bestrahlt worden waren. Dagegen standen Befunde von Davis (1924), der als erster radiogene Fibrösen und Blutungen des rechten Vorhofes bei Hunden und Kaninchen (und beim Menschen) beschrieb, oder von Hartmann et al. (1927) und Warthin u. Pohle (1931), die ähnliche Veränderungen an Schaf-, Hunde- und Rattenherzen nachwiesen. Jonek u. Kosmider (1963) fanden pathologische Enzymveränderungen des Herzmuskels bei bestrahlten Meerschweinchen. Solche Befunde wurden relativiert durch Berichte, nach denen Myokardnekrosen im Tierexperiment erst mit Dosen von 20 000 R auslösbar waren (Moss et al. 1963; Stone et al. 1964; Bishop et al. 1965).

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© Springer-Verlag Berlin Heidelberg 1989

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  • J. Slanina

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