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Fibrin Sealant and Its Modes of Application

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Fibrin Sealant in Operative Medicine

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Abstract

After reconstitution, the two components of fibrin sealant — sealer protein/aprotinin and thrombin/CaCl2 solution — can be applied in different ways. Besides sequential application or premixing of the reactant, application of the sealant components with the double-syringe applicator (Duploject) is advantageous in a number of ways, e.g., single-handed operation, thorough mixing, thin-layer application. Use of the Duploject is almost universally applicable. Thrombin concentration can be varied depending on the need for rapid or slow clotting of the sealants. The sealant can be delivered using needles, spray heads, or catheters, as indicated by the specific application. The spraying catheter can be easily used through the biopsy channel of an endoscope. Furthermore special micro-application techniques are possible. Fibrin sealant may also be used in connection with other biomaterials such as collagen (fleece), dura, and vascular grafts. Tests are reported on different collagen fleeces as well as on the addition of antibiotics. Finally visibility (including X-ray) and histological techniques are discussed.

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References

  1. Guttmann J (1979) Untersuchung eines Fibrinklebers für die Anwendung in der Chirurgie peripherer Nerven. Diplomarbeit, Technische Universität Wien

    Google Scholar 

  2. Seelich T, Redl H (1980) Theoretische Grundlagen des Fibrinklebers. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. FK Schattauer-Verlag, Stuttgart, New York (1980) 199–208

    Google Scholar 

  3. Redl H, Stanek G, Hirschl A, Schlag G (1982), Fibrinkleber-Antibiotika-Gemische — Festigkeit und Elutionsverhalten. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 18–21

    Google Scholar 

  4. Redl H, Schlag G, Stanek G, Hirschl A, Seelich T (1983) In vitro properties of mixtures of fibrin seal and antibiotics. Biomaterials 4: 29–32

    Article  PubMed  CAS  Google Scholar 

  5. Duckert F, Nyman D, Gastpar H (1978) Factor XIII fibrin and collagen. Coll Platelet Interact., FK Schattauer-Verlag, Stuttgart, New York, pp 391–396

    Google Scholar 

  6. Redl H, Schlag G (1986) Properties of different tissue sealants with special emphasis on fibrinogen based preparations. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume

    Google Scholar 

  7. Pflüger H, Redl H (1982) Abbau von Fibrinkleber in vivo und in vitro (Versuche an der Ratte mit besonderer Berücksichtigung der klinischen Relevanz). Z Urol Nephrol 75: 25–30

    PubMed  Google Scholar 

  8. Redl H, Schlag G, Dinges HP, Kuderna H, Seelich T (1982) Background and methods of fibrin sealing. In: Winter D, Gibbons DF, Plenk H (eds) Biomaterials. John Wiley and Sons Ltd (1982) 669–676

    Google Scholar 

  9. Stemberger A, Fritsche HM, Haas S, Spilker G, Wriedt-Lübbe I, Blümel G (1982) Biochemische und experimentelle Aspekte der Gewebeversiegelung mit Fibrinogen und Kollagen. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 290–293

    Google Scholar 

  10. Schlag G, Redl H, Thurnher M, Dinges HP (1986) The importance of fibrin in wound repair. In: Schlag G, Redl H (eds) Principles of fibrin sealant. Springer-Verlag, Heidelberg, Berlin, in press

    Google Scholar 

  11. Matras H, Dinges HP, Lassmann H, Mamoli B (1972) Zur nahtlosen interfaszikulären Nerventransplantation im Tierexperiment. Wr Med Wschr 122: 517

    CAS  Google Scholar 

  12. Redl H, Schlag G, Dinges HP (1982) Methods of fibrin seal application. Thorac Cardiovasc Surg 30: 223–227

    Article  PubMed  CAS  Google Scholar 

  13. Seelich T, Redl H (1979) Biochemische Grundlagen zur Klebemethode. Dtsch Z Mund-Kiefer-Gesichtschir 3: 22S–26S

    Google Scholar 

  14. Tange RA (1986) A new application method for fibrin sealant: glue gun. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine — otorhinolaryngology. Springer-Verlag, Heidelberg, Berlin, this volume

    Google Scholar 

  15. Redl H, Schlag G (1984) Background and methods of fibrin sealing. In: Skjoldborg H (ed) Scientific Workshop ’82: Tisseel/Tissucol-Symposium — Areas of application, problems and perspectives in current surgery. Immuno Denmark, pp 11–19

    Google Scholar 

  16. Chüden HG (1986) Simplified application of fibrinous glue in middle-ear surgery. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine — otorhinolaryngology. Springer-Verlag Heidelberg, Berlin, this volume

    Google Scholar 

  17. Servadio L (1983) Tisseal in liver surgery. (Film)

    Google Scholar 

  18. Pers M (1984) Scand. J. Plast. Reconstr. Surg. 17: 178

    Google Scholar 

  19. Riedmiller H, Thüroff JW (1985). In: Melchior H (ed.) Fibrinklebung in der Urologie. Springer-Verlag, Berlin Heidelberg New York, pp 71–76

    Chapter  Google Scholar 

  20. Haverich A, Walterbusch G, Oelert H, Borst HG (1984) In: Scheele J (ed.) Fibrinklebung, Springer-Verlag, Berlin Heidelberg New York, pp 143–149

    Chapter  Google Scholar 

  21. Pridun N, Heindl W, Redl H, Schlag G, Machacek E (1986) In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume

    Google Scholar 

  22. Jessen C, Sharma P (1985) Ann. Thorac. Surg. 39: 521

    Article  PubMed  CAS  Google Scholar 

  23. Pridun N, Heindl W (1983) Wr. Klin. Wochenschr. 133, Suppl. 75: 40

    Google Scholar 

  24. Buchwald J (1984) In: Scheele J (ed.) Fibrinklebung, Springer-Verlag, Heidelberg Berlin, New York, pp 169–172

    Chapter  Google Scholar 

  25. Waclawiczek H, Wayand W, Chmelicek A (1986) In: Schlag G, Redl H (eds.) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume

    Google Scholar 

  26. Flicker M, Pesendorf FX, Redl H (1985) Wr. Med. Wochenschrift 135, Suppl. 90:21

    Google Scholar 

  27. Armengol JR (1985) In: Schlag G, Redl H (eds.) Fibrin sealant in operative medicine, Springer-Verlag, Heidelberg, this volume

    Google Scholar 

  28. Linscheer WG, Fazio TL (1979) Control of upper gastrointestinal hemorrhage by endoscopic spraying of clotting factor. Gastroenterology 77: 642–645

    PubMed  CAS  Google Scholar 

  29. Pridun N, Heindl W (1983) Fibrinspraytherapie beim Spontanpneumothorax. Wr Klin Wochenschr 133, Suppl 75: 40

    Google Scholar 

  30. Dinges HP, Redl H, Schlag G (1982) Histologische Techniken und tierexperimentelle Modelle zur Untersuchung der Wechselwirkung zwischen Fibrinkleber und Gewebe. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 44–51

    Google Scholar 

  31. Siedentop KH, Harris D, Loewy A (1983) Experimental use of fibrin tissue adhesive in middle ear surgery. Laryngoscope 93: 1310–1313

    PubMed  CAS  Google Scholar 

  32. Ferry JD, Morrison PR (1950) Fibrin clots and methods for preparing the same. United States Patent, Dec 5, 2,533,004

    Google Scholar 

  33. Braun A, Schumacher G, Kratzat R, Heine WD, Pasch B (1980) Der Fibrin-Antibiotika-Verband im Tierexperiment zur lokalen Therapie des Staphylokokken infizierten Knochens. H Unfallheilkunde 148: 809

    Google Scholar 

  34. Bösch P, Lintner F, Braun F (1979) Die autologe Spongiosatransplantation unter Anwendung des Fibrinklebesystems im Tierexperiment. Wr Klin Wochenschr 91: 628

    Google Scholar 

  35. Stanek G, Bösch P, Weber P, Hirschl A (1980) Experimentelle Untersuchungen für das pharmakokinetische Verhalten lokal applizierter Antibiotika. Acta Med Austriaca 4, Suppl 20: 19

    Google Scholar 

  36. Wahlig H, Dingeldein E, Braun A, Kratzat R (1982) Fibrinkleber und Antibiotika — Untersuchungen zur Freisetzungskinetik. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie, Georg Thieme Verlag, Stuttgart, New York, pp 182

    Google Scholar 

  37. Richling B (1982) Homologous controlled-viscosity fibrin for endovascular embolization. Part. I: Experimental development of the medium. Acta Neurochir 62: 159

    Article  CAS  Google Scholar 

  38. Heine WD, Braun A, Edinger D (1982) Gewebliche Abwehrreaktionen auf das Fibrinklebesystem. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Georg Thieme Verlag, Stuttgart, New York, pp 277

    Google Scholar 

  39. Barrett PN, Dorner F, Eibl J (1986) In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume

    Google Scholar 

  40. Eder G, Neumann M, Cerwenka R, Baumgarten K. In: Schlag G, Redl H (eds) Fibrin sealant in Operative Medicine. Springer-Verlag, Heidelberg, Berlin, this volume

    Google Scholar 

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Authors
  1. H. Redl
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  2. G. Schlag
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle Traumatologie, Donaueschingenstr. 13, A-1200, Vienna, Austria

    Günther Schlag  & Heinz Redl  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Redl, H., Schlag, G. (1986). Fibrin Sealant and Its Modes of Application. In: Schlag, G., Redl, H. (eds) Fibrin Sealant in Operative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95513-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-95513-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17280-2

  • Online ISBN: 978-3-642-95513-6

  • eBook Packages: Springer Book Archive

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