Use of Fibrin Sealant (Tissucol/Tisseel) in Manual and Stapled Anastomoses

  • G. Romeo
  • F. Basile
  • G. Giannone
  • A. Iuppa
  • L. Sandonato
  • O. E. Chiarenza
Conference paper

Abstract

We present a study on the use of a human fibrin sealant (Tissucol) to prevent anastomotic dehiscence in digestive surgery. The study evaluates:
  1. 1.

    the appropiate modality of application of Tissucol,

     
  2. 2.

    the intraoperative leakage rate before and after application of Tissucol, and

     
  3. 3.

    the postoperative leakage rate in 42 patients with gastrointestinal anastomosis.

     

The results show 25% minor leaks in 32 colorectal and esophagojejunal anastomoses before application of Tissucol and no leaks after application of Tissucol. We conclude in favor of the use of Tissucol in high-risk manual or stapled anastomoses.

Key words

Stapled anastomoses Tissucol 

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References

  1. 1.
    Borsr HG, Dragojevic D, Stegmann T, Hetzer R (1978) Anastomotic leakage, stenosis and reflux after esophageal replacement. World J Surg 2:861–6CrossRefGoogle Scholar
  2. 2.
    Clemmesen T (1983) Application of Tisseel in colon anastomosis. Boll Inform ImmunoGoogle Scholar
  3. 3.
    Goligher JC, Graham NG, De Dombal FT (1970) Anastomotic dehiscence after anterior resection of rectum and sigmoid. Br J Surg 57:109–18PubMedCrossRefGoogle Scholar
  4. 4.
    Graffner H, Fredlund P, Olsson S, Oscarson J, Petersson B (1983) Protective colostomy in low anterior resection of the rectum using the EEA stapling instrument. A randomized study. Dis Col &Rec 26:87–90CrossRefGoogle Scholar
  5. 5.
    Harrison RC, Oka H (1982) Rectal anastomosis: sutures vs staples and glue. Contem SurgGoogle Scholar
  6. 6.
    Hermirich AS, Crawford D G (1976) The esophageal anastomotic leak. Am J Surg 132:794–8CrossRefGoogle Scholar
  7. 7.
    Iuppa A, Basile F, Sandonato L, Romeo G (1984) La nostra esperienza sull’impiego del Tissucol in chirurgia generale. Oriz Chir 2:409–16Google Scholar
  8. 8.
    Maillet P, Baulieux J, Benhaim R (1982) Carcinoma of the thoracic esophagus (result of one-stage surgery, 271 cases) Am J Surg 143:629–34Google Scholar
  9. 9.
    Nociti V e coll (1982) L’impiego del Tissucol nelle anastomosi monostrato del colon Ortop e Traumatol oggiGoogle Scholar
  10. 10.
    Oka H, Harrison RC, Burhenne HJ (1982) Effect of a biologic glue on the leakage rate of experimental rectal anastomoses. Am J Surg 143:561–4PubMedCrossRefGoogle Scholar
  11. 11.
    Schuchmann GF, Heydron WH, Hall RV et al (1980) Treatment of esophageal carcinoma (a retrospective review). J Thorac Cardiovas Surg 79:67–73Google Scholar
  12. 12.
    Scheel J, Muhe E (1980) Consolidamento delle anastomosi del tratto digerente per mezzo della colla di fibrina. Boll Inform ImmunoGoogle Scholar
  13. 13.
    Smith LE (1981) Anastomosis with EEA stapler after anterior colonic resection. Dis Coll & Rec 24:236–42CrossRefGoogle Scholar
  14. 14.
    Thorson GK, Perez-Brett R, Lillie DB et al (1983) The role of the tissue adhesive seal (FS) in esophageal anastomoses. J Surg Oncol 24:221–3PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Romeo
  • F. Basile
  • G. Giannone
  • A. Iuppa
  • L. Sandonato
  • O. E. Chiarenza

There are no affiliations available

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