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The Importance of Fibrin in Wound Repair

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Book cover Fibrin Sealant in Operative Medicine

Abstract

A review is given, beginning with the inflammatory phase of wound healing and explaining the role of macrophages, platelets, and granulocytes. Beside the cellular response the special importance of fibrin and factor XIII is demonstrated, particularly their function for fibroplasia. Special emphasis is put on the effect of highly concentrated fibrin — fibrin sealant. Its beneficial role in promoting the growth of fibroblasts is shown by a study on rats, in which a new model of granulation tissue formation was used. With this model it can be demonstrated that the application of fibrin sealant leads to significantly higher amounts of fibroblasts in newly formed granulation tissue. However, it is also demonstrated that fibrin sealant cannot overcome the inhibition of wound healing caused by, for example, adriamycin, though the beneficial effect of fibrin sealant in other cases of disturbed wound healing, e.g., ulcus cruris, has been demonstrated previously.

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Authors
  1. G. Schlag
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  2. H. Redl
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  3. M. Turnher
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  4. H. P. Dinges
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle Traumatologie, Donaueschingenstr. 13, A-1200, Vienna, Austria

    Günther Schlag  & Heinz Redl  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Schlag, G., Redl, H., Turnher, M., Dinges, H.P. (1986). The Importance of Fibrin in Wound Repair. In: Schlag, G., Redl, H. (eds) Fibrin Sealant in Operative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95513-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-95513-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17280-2

  • Online ISBN: 978-3-642-95513-6

  • eBook Packages: Springer Book Archive

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