The Importance of Fibrin in Wound Repair

  • G. Schlag
  • H. Redl
  • M. Turnher
  • H. P. Dinges
Conference paper


A review is given, beginning with the inflammatory phase of wound healing and explaining the role of macrophages, platelets, and granulocytes. Beside the cellular response the special importance of fibrin and factor XIII is demonstrated, particularly their function for fibroplasia. Special emphasis is put on the effect of highly concentrated fibrin — fibrin sealant. Its beneficial role in promoting the growth of fibroblasts is shown by a study on rats, in which a new model of granulation tissue formation was used. With this model it can be demonstrated that the application of fibrin sealant leads to significantly higher amounts of fibroblasts in newly formed granulation tissue. However, it is also demonstrated that fibrin sealant cannot overcome the inhibition of wound healing caused by, for example, adriamycin, though the beneficial effect of fibrin sealant in other cases of disturbed wound healing, e.g., ulcus cruris, has been demonstrated previously.

Key words

wound healing fibrin macrophages granulocytes 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Schlag
  • H. Redl
  • M. Turnher
  • H. P. Dinges

There are no affiliations available

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