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Outcome and Prediction of Outcome in Schizophrenia: Results from the Literature and from Two Personal Studies

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Treatment of Schizophrenia

Abstract

A large number of studies investigating the outcome of schizophrenia have been carried out. These studies have provided many hypotheses about the course of the illness, especially the characteristics of and the prediction of the outcome. However, the findings of the earlier studies have been questioned because of severe methodological deficiencies. In most of these studies, retrospective evaluation techniques or insufficiently standardized instruments were employed and many have introduced significant bias. Some more recent studies, however, have avoided such methodological problems by studying patients prospectively. Unfortunately, these excellent studies have evaluated patients only over short periods of time, generally from 1 to 2 years (e.g., Schooler, Goldberg, Boothe, and Cole, 1967; Astrachan, Brauer, Harrow, and Schwartz, 1974; Hogarty, Goldberg, Schooler, and Ullrich, 1974; Strauss and Carpenter, 1974; Wittenborn, McDonald, and Maurer, 1977; World Health Organization, 1979). Only the 5-year follow-up study of patients in the International Pilot Study of Schizophrenia (IPSS) covers a longer period of time. Thus far, data from this 5-year follow-up study have only been published by the Washington Research Center of the IPSS (Hawk, Carpenter, and Strauss, 1975; Strauss and Carpenter, 1977).

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Möller, H.J., Schmid-Bode, W., Wittchen, H.U., Zerssen, D.v. (1986). Outcome and Prediction of Outcome in Schizophrenia: Results from the Literature and from Two Personal Studies. In: Goldstein, M.J., Hand, I., Hahlweg, K. (eds) Treatment of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95496-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-95496-2_2

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