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Dopaminergic Agonists and Receptors: Their Relevance to the Treatment of Parkinson’s Disease

  • D. B. Calne
  • T. A. Larsen
Conference paper

Abstract

Following the recognition of dopamine as a neurotransmitter, and the discovery of its depletion in parkinsonism, therapy for this disorder has been focused on achieving increased activation of striatal dopaminergic receptors. Initially, this end was accomplished by administering the precursor of dopamine, levodopa; certain unwanted effects of this amino acid, notably nausea and vomiting, were alleviated by concomitant administration of drugs, (carbidopa and benserazide) that blocked the conversion of levodopa to dopamine by L-aromatic amino acid decarboxylase. These enzyme inhibitors were chosen because they did not readily cross the blood-brain barrier, so they did not impede the formation of dopamine in the striatum.

Keywords

Dopamine Receptor Parkinson Disease Dopamine Agonist Parkinsonian Patient Dopaminergic Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • D. B. Calne
  • T. A. Larsen

There are no affiliations available

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