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Budipine in the Treatment of Extrapyramidal Disorders Not Related to Parkinson’s Disease

  • D. Müller
Conference paper

Abstract

Budipine is a new drug in the treatment of Parkinson’s disease. According to preliminary experience, it is effective against tremor and rigidity as well as against akinesia. It was demonstrated that this new diphenylpiperidine derivative is effective in both monoaminergic and cholinergic neurotransmitter systems. It seems to be able to stimulate dopaminergic, noradrenergic, and serotonergic activity and to act as an anticholinergic drug (Menge and Brand 1982). Thus, it is able to influence all symptoms of Parkinson’s disease. In our present study, the results of budipine therapy in patients suffering from other extrapyramidal disorders, such as spasmodic torticollis dystonicus, choreoathetoid hyperkinesia, intention hyperkinesia, and essential tremor, are reported.

Keywords

Essential Tremor Residual Symptom Serotonergic Activity Intention Tremor Spasmodic Torticollis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hassler R (1953) Extrapyramidal-motorische Syndrome und Erkrankungen. In: Jung R (ed) Neurologie, 4th edn. Springer, Berlin Heidelberg New York (Handbuch der Inneren Medizin, vol 5/3)Google Scholar
  2. Hassler R, Dieckmann G (1970) Die stereotaktische Behandlung des Torticollis aufgrund tierexperimenteller Erfahrungen über die richtungsbestimmten Bewegungen. Nervenarzt 41: 743–487Google Scholar
  3. Menge HG, Brand U (1982) Zusammenfassende Darstellung der Pharmakologie von Budipin, einem neuen 4,4-Diphenylpiperidin-Derivat für die Parkinson Therapie. Drug Res 32: 85–98Google Scholar
  4. Müller D (1983) Stereotaktische Behandlung extrapyramidaler Krankheiten. In: Hopf HC, Poeck K, Schliack H (eds) Neurologie in Praxis und Klinik, vol 1. Thieme, Stuttgart, pp 6.82–6.87Google Scholar
  5. Riechert T, Richter D (1972) Operative Behandlung des Tremors der Multiplen Sklerose und des essentiellen Tremors. Münch Med Wschr 114: 2025–2028PubMedGoogle Scholar
  6. Saavedra JL (1979) Der Torticollis spasticus und seine stereotaktische Behandlung. Dissertation, University of GöttingenGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • D. Müller

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