Budipine in the Treatment of Extrapyramidal Disorders Not Related to Parkinson’s Disease

  • D. Müller
Conference paper


Budipine is a new drug in the treatment of Parkinson’s disease. According to preliminary experience, it is effective against tremor and rigidity as well as against akinesia. It was demonstrated that this new diphenylpiperidine derivative is effective in both monoaminergic and cholinergic neurotransmitter systems. It seems to be able to stimulate dopaminergic, noradrenergic, and serotonergic activity and to act as an anticholinergic drug (Menge and Brand 1982). Thus, it is able to influence all symptoms of Parkinson’s disease. In our present study, the results of budipine therapy in patients suffering from other extrapyramidal disorders, such as spasmodic torticollis dystonicus, choreoathetoid hyperkinesia, intention hyperkinesia, and essential tremor, are reported.


Essential Tremor Residual Symptom Serotonergic Activity Intention Tremor Spasmodic Torticollis 
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© Springer-Verlag Berlin Heidelberg 1985

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  • D. Müller

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