Histopathological Aspects of Myocarditis with Special Reference to Mumps, Cytomegalovirus Infection and the Role of Endomyocardial Biopsy
Myocarditis has been defined as “an inflammatory process of the heart muscle due to known or unknown causes, excluding atherosclerosis of the coronary arteries”, which may or may not be associated with inflammation elsewhere in the body” . This definition is probably agreeable to most. For practical purposes, however, it is often difficult to establish morphologically whether or not certain structural changes are of an inflammatory (infectious) origin. Ischaemic heart disease must be excluded, which is not always easy or clear-cut; and what about the flabby, enlarged heart without significant cell infiltration at histological examination and for which an aetiological explanation cannot be traced? Is it caused by excessive alcohol consumption? Is it a sequel of myocarditis or the aftermath of exposition to toxic agents in the environment? What really constitutes the disease known as “dilated (congestive) cardiomyopathy”?
KeywordsCorticosteroid Influenza Luminal Cardiomyopathy Cardiol
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- 6.Daly K, Richardson PJ, Olsen EGJ, Pattison J, Jackson G, Jewitt DE (1981) Immunosuppresive therapy in acute inflammatory myocarditis (abstract). Circulation 64 [Suppl IV]: IV-27Google Scholar
- 8.Hunt SA, Rider AK, Stinson EB, Griepp RB, Schroeder JS, Harrison DC, Shumway NE (1976) Does cardiac transplantation prolong life and improve its quality? Circulation 54 [Suppl.3]: 56–60Google Scholar
- 12.Kussy JC (1976) Fatal mumps myocarditis. Minn Med 57: 285–6Google Scholar
- 15.MacArthur CGC, Cambridge G, Waterson AP, Goodwin JF, Oakley CM (1978) Antibodies to Coxsackie B viruses in primary congestive cardiomyopathy (abstract). Br Heart J 40: 456Google Scholar
- 17.Manca C (1932) Miocardite da parotite epidemica. Arch Ital Anat Istol Pat 3: 707Google Scholar
- 21.Olsen EGJ (1980) The pathology of the heart, 2nd edn. Macmillan, London, p 178Google Scholar
- 30.Weiss M, Drusin R, Fenoglio JJ Jr (1979) Chronic myocarditis and cardiomyopathy: a clinical pathological study (abstract). Circulation 59–60 [Suppl II]: 156Google Scholar
- 35.Woodruff JF (1980) Viral myocarditis. A review. Am J Pathol 101: 427–79Google Scholar