The Role of Eosinophils in Myocarditis
The association of a persistent blood eosinophilia with the development of endomyocardial disease (eosinophilic endomyocardial disease) is now well described, and it has been suggested that eosinophils themselves may be involved in tissue injury leading to chronic heart disease . It has also been suggested that tropical endomyocardial disease, in which a peripheral blood eosinophilia is less marked, may also be due to a toxic effect of eosinophilis on heart muscle . Other forms of heart disease in which eosinophils are prominent include parasitic , granulomatous  and hypersensitivity disorders , which usually present as an acute systemic illness.
KeywordsDilate Cardiomyopathy Eosinophil Cationic Protein Hypereosinophilic Syndrome Peripheral Blood Eosinophilia Chronic Heart Disease
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- 2.Brockington IF, Luzzatto L, Osunkoya BO (1970) The heart in eosinophilic leukemia. Afr J Med Sei 1: 343–352Google Scholar
- 5.Davies J, Spry CJF, Vijararaghavan G, deSouza JA (1983) A comparison of the clinical and cardiological features of endomyocardial disease in temperate and tropical regions. Postgrad Med J 59: 51–55Google Scholar
- 6.Olsen EGJ, Spry CJF (1977) The pathogenesis of Löffler’s endomyocardial disease, and its relationship to endomyocardial fibrosis. Prog Cardiol 8: 281–303Google Scholar
- 7.Shapiro LG (1919) Eosinophilic (polymorphonuclear) leukemia. Proc NY Pathol Sci 19: 73–83Google Scholar
- 10.Spry CJF, Tai P-C, Davies J (1982) Eosinophils and endomyocardial fibrosis. Contrib Microbiol Immunol 7: 212–217Google Scholar
- 12.Tai P-C, Holt M, Gibbs AM, Williams BD, Spry CJF (to be published) The deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis - the Churg and Strauss syndrome.Google Scholar
- 13.Tai P-C, Spry CJF, Peterson C, Venge P, Olsson I (to be published) Activated and degranulating human eosinophils defined with monoclonal antibodies.Google Scholar