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Mediatoren der allergischen Reaktion

  • Conference paper
Immunologie in Anaesthesie und Intensivmedizin

Part of the book series: Sertürner Workshops Einbeck ((MGPPT))

  • 26 Accesses

Zusammenfassung

Klinische Erfahrungswerte wie auch experimentelle Untersuchungen der letzten Jahre haben eindeutig erwiesen, daß allergische wie entzündliche Reaktionen ein Kontinuum von immunologischen Folgeabläufen sind.

Die Mediatoren der Entzündung stehen dabei in einem Wechselspiel zueinander und bestimmen das zelluläre Infiltrat, das sowohl für die Persistenz der akuten, subakuten und chronischen Entzündung verantwortlich ist. Die Aktivierung von neutrophilen Granulozyten und mononukleären Zellen durch mannigfaltige Stimuli ergibt einen neuen pathophysiologischen Rahmen für die Auslösung des Krankeitsbildes “Bronchospasmus-Asthma”.

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Literatur

  1. Atkins PC, Norman M, Weiner H (1979) Release of neutrophil chemotactic activity during immediate hypersensitivity reactions. Ann Intern Med 86: 415

    Article  Google Scholar 

  2. Bach MK, Brashler JR (1978) Ionophore A 23187-induced production of slow reacting substance of anaphylaxis (SRS-A) by rat peritoneal cells in vitro: evidence for production by mononuclear cells. J Immunol 120: 998

    PubMed  CAS  Google Scholar 

  3. Bills TK, Smith JB, Silver MJ (1977) Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin. J Clin Invest 60: 1

    Article  PubMed  CAS  Google Scholar 

  4. Borgeat P, Samuelsson B (1979) Arachidonic acid metabolism in polymorphonuclear leukocytes: Effects of ionophore A 23187. PNAS 76: 214E

    Google Scholar 

  5. Borgeat P, Samuelsson B (1979) Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids. PNAS 76: 3213

    Google Scholar 

  6. Czarnetzki BM, König W, Lichtenstein LM (1976) Eosinophil chemotactic factor (ECF). I. Release from polymorphonuclear leukocytes by the calcium ionophore A 23187. J Immunol 117: 229

    PubMed  CAS  Google Scholar 

  7. Frickhofen N, König W (1979) Subcellular localization of the eosinophil chemotactic factor (ECF) and its inactivator in human polymorphonuclear leucocytes ( PMN ). Immunology 37: 11

    Google Scholar 

  8. Goetzl EJ, Austen KF (1975) Purification and synthesis of eosinophilotactic tetrapeptide of human lung tissue: identification and eosinophil-chemotactic factor of anaphylaxis. PNAS 72: 4123

    Article  PubMed  CAS  Google Scholar 

  9. Goetzl EJ, Valone FH, Reinhold VN, Gorman RR (1979) Specific inhibition of the polymorphonuclear leucocyte chemotactic response to hydroxy-fatty acid metabolites of arachidonic acid by methylester derivatives. J Clin Invest 63: 1181

    Article  PubMed  CAS  Google Scholar 

  10. Goetzl EJ, Woods JM, Gorman RR (1977) Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. J Clin Invest 59: 179

    Article  PubMed  CAS  Google Scholar 

  11. Goetzl EJ, Gorman RR (1978) Chemotactic and chemokinetic stimulatior of human eosinophil and neutrophil polymorphonuclear leukocytes by 12-L-hydroxy-5,8,10-heptadecatrienoic acid ( HHT ). J Immunol 120: 526

    Google Scholar 

  12. Goetzl EJ, Derian C, Valone FH (1980) The extra-cellular and intracellular roles of hydroxy-eicosatetraenoic acids in the modulation of polymorphonuclear leukocyte and macrophage function. J.R.E.S. 28, S. Dec. 105s

    Google Scholar 

  13. Hommarström S, Murphy AC, Samuelsson B (1979) Structure of leukotriene C. Identification of the amino acid part. Biochem Biophys Res Comm 91: 1266

    Google Scholar 

  14. Hammarström S, Samuelsson B (1980) Stereochemistry of leukotriene C-1. Biochem Biophys Res Comm 92: 946

    Article  PubMed  Google Scholar 

  15. Hanahan DJ, Demopoulos CA, Liehr J, Pinchard RN (1980) Identification of naturally occurring platelet activing factor isolated from rabbit basophils as acetyl glyceryl ether phosphoryl choline. J Biol Chem 255: 5514

    PubMed  CAS  Google Scholar 

  16. Henson PM (1980) An overview of lipid mediators in the inflammatory process.J.R.E.S. 28, S. Dec. 93s

    Google Scholar 

  17. Hirata F, Toyoshima S, Axelrod J, Waxdal M (1980) Phospholipid methylation: A biochemical signal modulating lymphocyte mitogens. PNAS 77: 862

    Google Scholar 

  18. Hirata F, Corcoran BA, Venkatasubramanian K, Schiffmann E, Axelrod J (1979) Chemoattractants stimulate degradation of methylated phospholipids and release of arachidonic acid in rabbit leukocytes. PNAS 76: 2640

    Article  PubMed  CAS  Google Scholar 

  19. Hogg JC, Pare PD, Boucher RC, Michoud MC (1979) The pothophysiology of asthma. CMAJ 121: 409

    CAS  Google Scholar 

  20. Jakschik BA, Falkenhein S, Parker CW (1977) Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cell. PNAS 74: 4577

    Article  PubMed  CAS  Google Scholar 

  21. König W (1978) Die immunologische Rolle des Histamins und seine Bedeutung für die Allergiediagnostik. Immun Infekt 1: 38

    Google Scholar 

  22. König W (1978) Struktur und Funktion des eosinophilen Leukozyten. Immun Infekt 6: 97

    PubMed  Google Scholar 

  23. König W, Czarnetzki BM, Lichtenstein LM (1976) Eosinophil chemotactic factor (ECF). II. Release during phagocytosis of human polymorphonuclear leukocytes. J Immunol 117: 235

    Google Scholar 

  24. König W, Frickhofen N, Tesch H (1979) Generation and secretion of eosinophilotactic activity from polymorphonuclear neutrophils by various mechanisms of cell activation. Immunology 36: 733

    PubMed  Google Scholar 

  25. König W, Kroegel C, Möller G, Tesch H, Theobald K, Bohn A (1980) Interzellulare Regulation der allergischen Reaktion durch Mastzellen, Eosinophile und Neutrophile. Krankenhausarzt 3: 211

    Google Scholar 

  26. König W, Kroegel C, Tesch H (1980) Generation and modulation of the eosinophil chemotactic factor ( ECF) from human PMN and rat mononuclear cells by phospholipids. Fed Proc 39: 691

    Google Scholar 

  27. König W, Pfeiffer Ph, Kunau HW (1981) Effect of arachidonic acid metabolites on the histamine release from basophils and rat mast cells. Monogr Allergy (im Druck )

    Google Scholar 

  28. König W, Tesch H, Frickhofen N (1978) Generation and release of eosinophil chemotactic factor from human polymorphonuclear neutrophils by arachidonic acid. Eur J Immunol 8: 434

    Article  PubMed  Google Scholar 

  29. König W, Theobald K, Möller G, Pfeiffer PH, Bohn A (1981) The IgEreceptor. In Ring J Burg G(Eds): New trends in allergy. Springer, Berlin Heidelberg New York p 21

    Chapter  Google Scholar 

  30. Kroegel C, König W, Molloy C, Kreil G (1981) Generation of the eosinophil chemotactic factor ( ECF) from various cell types by melittin. Mol Immunol 18: 227

    Google Scholar 

  31. Marone G, Kagey-Sabotka A, Lichtenstein LM (1979) Effects of arachidonic acid and its metabolites on antigen induced histamine release from human basophils in vitro. J Immunol 123: 1669

    PubMed  CAS  Google Scholar 

  32. Morris HR, Taylor GW, Piper PJ, Tippins JR (1980) Structure of slow reacting substance of anaphylaxis from guinea pig lung. Nature 285: 104

    Article  PubMed  CAS  Google Scholar 

  33. Naccache PH, Showell HJ, Becker EL, Sha’Afi RI (1979) Arachidonic acid induced degranulation of rabbit peritoneal neutrophils. Biochem Biophys Res Commun 87: 292

    Article  PubMed  CAS  Google Scholar 

  34. Nadel JA, Davis B, Phipps RJ (1979) Control of mucus secretion and ion transport in airways. Ann Rev Physiol 41: 369

    Article  CAS  Google Scholar 

  35. Radmark V, Malmsten C, Samuelsson B (1980) Leukotriene A:stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92: 954

    Article  PubMed  CAS  Google Scholar 

  36. Ritterhouse-Simmons S, Deykin D (1977) The mobilization of arachi-donic acid in platelets exposed to thrombin or ionophore A 23187. J Clin Invest 60: 495

    Article  Google Scholar 

  37. Stenson WF, Parker CM (1980) Monohydroxy eicosatetraenoic acids ( HETEs) induce degranulation of human neutrophils. J Immunol 124: 2100

    Google Scholar 

  38. Sullivan TJ, Parker CM (1979) Possible role of arachidonic acid and its metabolites on antigen induced histamine release from human basophils in vitro. J Immunol 123: 1669

    Google Scholar 

  39. Tesch H, König W (1980) Phospholipase A2 and Arachidonic Acid: a common link in the generation of the eosinophil chemotactic factor ( ECF) from human PMN by various stimuli. Scond J Immunol 11: 409

    Google Scholar 

  40. Waite M,De Chatelet LR, King L, Shirley PS (1979) Phagocytosis induced release of arachidonic acid from human neutrophils. Biochem Biophys Res Comm 90: 984

    Article  Google Scholar 

  41. Wassermann SI, Soter NA, Center DM (1977) Cold urticaria: Recognition and characterization of a neutrophil chemotactic factor which appears in serum during experimental cold challenge. J Clin Invest 60: 189

    Google Scholar 

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Authors
  1. W. König
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  2. Ph. Pfeiffer
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  3. A. Bohn
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Editor information

Editors and Affiliations

  1. Abteilung für Anaesthesiologie, Chirurgische Universitätsklinik und Poliklinik München — Innenstadt, Pettenkoferstr. 8a, 8000, München 2, Deutschland

    A. Doenicke

  2. Universitätsfrauenklinik und Hebammenlehranstalt, Sigmund-Freud-Str. 25, 5300, Bonn 1, Deutschland

    U. D. Koenig

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© 1983 Springer-Verlag Berlin Heidelberg

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König, W., Pfeiffer, P., Bohn, A. (1983). Mediatoren der allergischen Reaktion. In: Doenicke, A., Koenig, U.D., Doenicke, S. (eds) Immunologie in Anaesthesie und Intensivmedizin. Sertürner Workshops Einbeck. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95430-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-95430-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12199-2

  • Online ISBN: 978-3-642-95430-6

  • eBook Packages: Springer Book Archive

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