Remote Functional Depression of Glucose Metabolism in Stroke and its Alteration by Activating Drugs

  • W.-D. Heiss
  • H. W. Ilsen
  • R. Wagner
  • G. Pawlik
  • K. Wienhard


Applying the [18F]fluorodeoxyglucose (FDG) method (Reivich et al. 1979a; Phelps 1981) and positron emission tomography (PET) in man, increased local cerebral metabolic rates for glucose (LCMRGl) during functional activation of nervous tissue have been demonstrated for the visual system (Reivich et al. 1979b; Phelps et al. 1981a), for the auditory system (Alavi et al. 1981; Phelps et al. 1982), and for the somatosensory system (Greenberg et al. 1981). By means of the 77Kr inhalation technique, an increase in local cerebral blood flow (LCBF) was documented in the motor area after complicated finger movements (Roland et al. 1981). Some of these striking results and prospects on future studies have been reported by Phelps and Mazziotta (this volume) and Reivich et al. (this volume). In other studies of cerebral metabolism in patients suffering from ischemic stroke, a depression of oxygen uptake or glucose metabolism was observed in morphologically intact brain regions: Kuhl et al. (1980) described a reduction of glucose uptake in the thalamus ipsilateral to a cortical infarct. Using FDG (Phelps et al. 1981b) or [11C]3-methyl-Dglucose (Heiss et al. 1982) as metabolic tracer, decreased glucose uptake was found in the CT-intact visual cortex of patients with an infarction in the territory of the middle cerebral artery by which the visual pathway was interrupted.


Positron Emission Tomography Cereb Blood Flow Cerebral Glucose Metabolism Local Cerebral Blood Flow Glucose Metabolic Rate 
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  1. 1.
    Alavi A, Reivich M, Greenberg J et al. (1981) Mapping of functional activity in brain with [18F] fluorodeoxyglucose. Semin Nucl Med 11: 24–31PubMedCrossRefGoogle Scholar
  2. 2.
    Baron JC, Bousser MG, Comar D et al. (1981) Crossed cerebellar diaschisis: A remote functional depression secondary to supratentorial infarction in man. J Cereb Blood Flow Metabol 1 [Suppl 1]: 500–501Google Scholar
  3. 3.
    Crane PD, Pardridge WM, Braun LD et al. (1981) The interaction of transport and metabolism on brain glucose utilization: A reevaluation of the lumped constant. J Neurochem 36: 1601–1604PubMedCrossRefGoogle Scholar
  4. 4.
    Eriksson L, Bohm Ch, Kesselberg M et al. (1982) A four ring positron camera system for emission tomography of the brain. IEEE Trans Nucl Sci 29: 539–543CrossRefGoogle Scholar
  5. 5.
    Ginsberg MD, Reivich M, Giandomenico A et al. (1977) Local glucose utilization in acute focal cerebral ischemia: local dysmetabolism and diaschisis. Neurology (Minneap) 27: 1042–1048Google Scholar
  6. 6.
    Greenberg J, Reivich M, Alavi A et al. (1981) Metabolic mapping of functional activity in human subjects with the [18F]-fluorodeoxyglucose technique. Science 212: 678–680PubMedCrossRefGoogle Scholar
  7. 7.
    Hawkins R, Phelps ME, Huang SC et al. (1981) Effect of ischemia on quantification of local cerebral glucose metabolic rate in man. J Cereb Blood Flow Metabol 1: 37–52CrossRefGoogle Scholar
  8. 8.
    Heiss WD, Vyska K, Kloster G et al. (1982) Demonstration of decreased functional activity of visual cortex by [11C]-methylglucose and positron emission tomography. Neuroradiology 23: 45–47PubMedCrossRefGoogle Scholar
  9. 9.
    Hoedt-Rasmussen K, Skinhej E (1964) Transneural depression of the cerebral hemispheric metabolism in man. Acta Neurol Scand 40: 41–46PubMedCrossRefGoogle Scholar
  10. 10.
    Huang SC, Phelps ME, Hoffman EJ et al. (1981) Error sensitivity of fluorodeoxyglucose method for measurement of cerebral metabolic rate of glucose. J Cereb Blood Flow Metabol 1: 391–401CrossRefGoogle Scholar
  11. 11.
    Kuhl DE, Phelps ME, Kowell AP et al. (1980) Effects of stroke on local cerebral metabolism and perfusion: mapping by emission computed tomography of 18FDG and 13NH3. Ann Neurol 8: 47–60PubMedCrossRefGoogle Scholar
  12. 12.
    Lenzi GL, Frackowiak RS, Jones T (1981) Regional cerebral blood flow (CBF), oxygen utilization (CMRO2) and oxygen extraction ratio (OER) in acute hemispheric stroke. J Cereb Blood Flow Metabol 1 [Suppl 1]: 504–505Google Scholar
  13. 13.
    Mazziotta JC, Phelps ME, Miller J et al. (1981) Tomographic mapping of human cerebral metabolism: normal unstimulated state. Neurology (Minneap) 31: 503–516Google Scholar
  14. 14.
    Meyer JS, Shinohara Y, Kanda T et al. (1970) Diaschisis resulting from acute unilateral cerebral infarction. Quantitative evidence for man. Arch Neurol 23: 241–247PubMedCrossRefGoogle Scholar
  15. 15.
    Mies G, Auer LM, Ebhardt G et al. (to be published) Flow and neuronal density in tissue surrounding chronic infarction. StrokeGoogle Scholar
  16. 16.
    Pede JP, Schimpfessel L, Crokaert R (1971) The action of piracetam on oxidative phosphorylation. Arch Int Physiol Biochem 79: 1036Google Scholar
  17. 17.
    Phelps ME (1981) Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine. Semin Nucl Med 11: 32–49PubMedCrossRefGoogle Scholar
  18. 18.
    Phelps ME, Huang SC, Hoffman EJ et al. (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2fluoro-2-deoxyglucose-D-glucose: validation of method. Ann Neurol 6: 371–388PubMedCrossRefGoogle Scholar
  19. 19.
    Phelps ME, Kuhl DE, Mazziotta JC (1981a) Metabolic mapping of the brain’s response to visual stimulation: studies in humans. Science 211: 1445–1448PubMedCrossRefGoogle Scholar
  20. 20.
    Phelps ME, Mazziotta JC, Kuhl DE et al. (1981b) Tomographic mapping of human cerebral metabolism: Visual stimulation and deprivation. Neurology (Minneap) 31: 517–529Google Scholar
  21. 21.
    Phelps ME, Mazziotta JC, Huang SC (1982) Study of cerebral function with positron computed tomography. J Cereb Blood Flow Metabol 2: 113–162CrossRefGoogle Scholar
  22. 22.
    Reivich M, Kuhl D, Wolf A et al. (1979a) The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137PubMedGoogle Scholar
  23. 23.
    Reivich M, Greenberg J, Alavi A et al. (1979b) The use of the [18F]fluoro-deoxyglucose technique for mapping of functional neural pathways in man. Acta Neurol Scand 60 [Suppl 72]: 198–199CrossRefGoogle Scholar
  24. 24.
    Roland P, Meyer E, Yamamoto Y et al. (1981) Dynamic positron emission tomography as a tool in neuroscience: Functional mapping in normal human volunteers. J Cereb Blood Flow Metabol 1, Suppl 1: 463–464Google Scholar
  25. 25.
    von Monakow C (1914) Die Lokalisation im Großhirn and der Abbau der Funktion durch kortikale Herde. Bergmann, WiesbadenGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • W.-D. Heiss
  • H. W. Ilsen
  • R. Wagner
  • G. Pawlik
  • K. Wienhard

There are no affiliations available

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