Measurement of Regional Cerebral Oxygen Consumption and Blood Flow in Man
The measurement of oxygen utilization and blood flow by positron emission tomography (PET) has presented a number of interesting challenges in the design of quantitative tracer strategies that respect the spatial and temporal resolution limitations of current PET tomographic systems. Because of the limited temporal resolution of most tomographic systems currently in operation, investigators have generally employed equilibrium strategies (Frackowiak et al. 1980) utilizing the continuous inhalation of radiolabeled oxygen and carbon dioxide. Such an approach yields quantitative values for local brain oxygen utilization and blood flow but does suffer from a number of limitations. The most notable of these is the long time necessary to accomplish such a measurement (e.g., 30 min). With the advent of PET imaging systems with improved temporal and spatial resolution (Ter-Pogossian et al. 1982) we have sought to employ techniques for the measurement of local cerebral blood flow and oxygen utilization that can be accomplished in a relatively short period of time (i. e., less than 1 min/measurement). Our general approach to this is detailed below.
KeywordsPositron Emission Tomography Cerebral Blood Volume Oxygen Utilization Positron Emission Tomograph Local Cerebral Blood Flow
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