Skip to main content
  • 73 Accesses

Abstract

In this review dealing with the rationale for combination chemotherapy of brain tumours, two main issues will be considered: (a) what are the characteristics of brain tumours most likely to determine the choice of chemotherapeutic drugs, and (b) is there any clinical evidence supporting the view that combination chemotherapy is superior to single-drug therapy in human brain neoplasms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blasberg, R., Patlack, C., Shapiro, W., Fenstermacher, J.: Metastatic brain tumours: local blood flow and capillary permeability. Neurology 29, 547, 1979

    Google Scholar 

  2. EORTC brain tumour group: Effect of CCNU on survival, rate of objective remission and duration of free interval in patients with malignant brain glioma: final evaluation. Europ. J. Cancer 14, 851–856, 1978

    Google Scholar 

  3. EORTC brain tumour group: Evaluation of the CCNU, VM26 plus CCNU and procarbazine in supratentorial brain gliomas. Final evaluation of a randomized study. J. Neurosurg. 55, 27–31, 1981

    Article  Google Scholar 

  4. Fewer, D., Wilson, C. B., Boldrey, E. B., Enot, K. J., Powell, M. R.: The chemotherapy of brain tumours: clinical experience in the carmustine (BCNU) and vincristine. JAMA 222, 544–559, 1972

    Article  Google Scholar 

  5. Hildebrand, J., Nouwynck, C.: Malignant gliomas. In: Randomized trials in cancer, a critical review by sites. M. J. Staquet (ed.), pp. 377–388. New York: Raven Press 1978

    Google Scholar 

  6. Hoshino, T., Barker, M., Wilson, C. B.: The kinetics of cultured human glioma cells. Acta Neuropathol. 32, 235–244, 1975

    Article  PubMed  CAS  Google Scholar 

  7. Levin, V. A., Patlack, C. S., Landahl, H. D.: Heuristic modelling of drug delivery to malignant brain tumour. J. Pharmacokinet. Biopharm. 8, 257–296 (1980)

    Article  PubMed  CAS  Google Scholar 

  8. Long, J. M.: Capillary ultrastructure and blood-brain barrier in human brain tumours. J. Neurosurg. 32, 127–144, 1970

    Article  PubMed  CAS  Google Scholar 

  9. Neuwelt, E. A., Diehl, J. T., Long, H. W., Hill, R. N., Michael, A. J., Frenkel, E. P.: Monitoring of methotrexate delivery in patients with malignant brain tumours after osmotic blood-brain barrier disruption. Ann. Intern. Med. 94, 449–454, 1981

    PubMed  CAS  Google Scholar 

  10. Norell, H., Wilson, C. B., Slagel, D. E., Clark, D. B.: Leukoencephalopathy following the administration of methotrexate in the cerebrospinal fluid in treatment of primary brain tumours. Cancer 33, 923–932, 1974

    Article  Google Scholar 

  11. Shapiro, W. R., Chernik, N. L., Posner, J. B.: Necrotizing encephalopathy following intraventricular instillation of methotrexate. Arch. Neurol. 28, 96–102, 1973

    Article  PubMed  CAS  Google Scholar 

  12. Shapiro, J. R., Yung, A., Wei-Kwan, Shapiro, W. R.: Isolation, karyotype and clonal growth of heterogeneous subpopulation of human malignant gliomas. Cancer Res. 41, 2349–2359, 1981

    PubMed  CAS  Google Scholar 

  13. van Putten, L. M., Keizer, H. J., Mulder, J. H.: Syndromization in tumour chemotherapy. Europ. J. Cancer 12, 79–85, 1976

    Google Scholar 

  14. Wilson, C. B., Gutin, P., Boldrey, E. B., Crafts, D., Levin, V. A., Enot, J.: Single agent chemotherapy of brain tumours. Arch. Neurol. 33, 739–144, 1976

    Article  PubMed  CAS  Google Scholar 

  15. Wilson, C. B., Yorke, C. H. Jr., Levin, V. A.: Intracranial malignant growth, primary and metastatic. In: Current problems in cancer. R. C. Hickey (ed.), Year Book Medical Publishers, Vol. I, Nr. 8, 1977

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hildebrand, J., de Beyl, D.Z. (1982). Rationale of Combined Chemotherapy of Brain Tumours. In: Voth, D., Gutjahr, P., Langmaid, C. (eds) Tumours of the Central Nervous System in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95413-9_55

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95413-9_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95415-3

  • Online ISBN: 978-3-642-95413-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics