Radiation Therapy in the Treatment of the Astrocytomas and Midline Tumours of Childhood

  • M. Herbst


Prior to the publication by WHO of the “Histological Typing of Tumours of the Central Nervous System” by Zülch in 1979 [17], both clinicians and pathologists were using a variety of different terminologies. Zülch listed five different readily dif-ferentiable astrocytomas (astrocytic tumours), together with a number of subtypes. Worthy of special mention is the pilocytic astrocytoma, which is also met with in the literature under the name juvenile astrocytoma. This tumour, which histologically resembles a spongioblastoma, is a slowly growing neoplasm, often located in the posterior cranial fossa. It can be completely removed surgically, and is considered to be not very sensitive to radiation [6, 10, 14]. However, Marsa et al. [13] report good long-term results from radiotherapy in such tumours located in the optic chiasm, the third ventricle, the hypothalamus and the cerebellum.


Brain Tumour Pilocytic Astrocytoma Astrocytic Tumour Posterior Cranial Fossa Astrocytoma Cerebellum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abramson, N., Raben, M., Cavanaugh, P. J.: Brain tumours in children. Analysis of 136 cases. Radiology 112, 669–672 (1974)PubMedGoogle Scholar
  2. 2.
    Arendt, A: Histologisch-diagnostischer Atlas der Geschwülste des Zentralnervensystems und seiner Anhangsgebilde. VEB Gustav-Fischer-Verlag: Jena, 1977Google Scholar
  3. 3.
    Arendt, A., Möller, B.: Hirngeschwülste im Kindesalter. Arch. Geschwulstforsch. 41, 164–171 (1973)PubMedGoogle Scholar
  4. 4.
    Bouchard, J.: Radiation therapy in brain tumours in children. In: Fletcher, G. H. (ed.): Textbook of Radiotherapy, pp. 482–498. Lea & Febiger: Philadelphia 1980Google Scholar
  5. 5.
    Burr, J. I. M., Slonim, A. E., Danish, R. K., Gadoth, N., Butler, J.: Diencephalic syndrome revisted. J. Pediatr. 88, 439–444 (1976)PubMedCrossRefGoogle Scholar
  6. 6.
    Camins, M. B., Schlesinger E. B.: Treatment of tumours of the posterior part of the third ventricle and the pineal region: A long term follow-up. Acta Neurochir. 40, 131–143 (1978)CrossRefGoogle Scholar
  7. 7.
    Concannaon, J., Kramer, S., Berry, R.: The extent of intracranial gliomata at autopsy and its relationship to technique used in radiation therapy of brain tumours. Am. J. Roentgenol. 84, 99–107 (1960)Google Scholar
  8. 8.
    Fazekas, J. T.: Treatment of grade I and II brain astrocytomas. The role of radiotherapy. Int. J. Rad. One. Biol. Phys. 2, 661–666 (1977)CrossRefGoogle Scholar
  9. 9.
    Hendrick, E. B., Hoffmann, H. J., Humphreys, R. P.: Treatment of infratentorial gliomas in childhood. In: Hekmatpanah, J.: Gliomas, Current concepts in biology, diagnosis and therapy. Recent results in cancer research, pp. 102–106. Springer-Verlag; Berlin, Heidelberg, New York: 1975Google Scholar
  10. 10.
    Hünig, R., Walther, E., Sauer, R.: Die Strahlentherapie von ZNS-Tumoren bei Kindern und Jugendlichen. Strahlentherapie 147, 573–597 (1974)PubMedGoogle Scholar
  11. 11.
    Leibel, S. A., Sheline, G. E., Wara, W. M., Boldrey, E. D., Nielson, S. L.: The role of radiation therapy in the treatment of astrocytoma. Cancer 35, 1551–1557 (1975)PubMedCrossRefGoogle Scholar
  12. 12.
    Lindgren, M.: Therapie des Gehirns und Rückenmarks bei Kindern. Deutscher Rönt-genkongreß 1967, Teil B, Strahlenbehandlung und Strahlenbiologie. Strahlentherapie Sdbde. 66, 180–189(1967)Google Scholar
  13. 13.
    Marsa, G. W., Probert, J. C., Rubinstein, L. G., Bagshaw, M. A.: Radiation therapy in the treatment of childhood astrocytic gliomas. Cancer 32, 646–655 (1973)PubMedCrossRefGoogle Scholar
  14. 14.
    Marsden, H. B., Steward, J. K.: Tumors in children. Recent results in cancer research, pp. 1–13, 137–193.. Springer-Verlag; Berlin, Heidelberg, New York: 1976Google Scholar
  15. 15.
    Salazar, O. M., Rubin, P., McDonald, J. V., Feldstein, M. L.: Patterns of failure in intracranial astrocytomas after irradiation: analysis of dose and field factors. Am J. Roentgenol. 126, 279–292(1976)Google Scholar
  16. 16.
    Sheline, G. E.: Radiation therapy of primary tumours. Seminars of Oncology 2, 29–42 (1975)Google Scholar
  17. 17.
    Zülch, K. J.: Histological typing of tumours of the central nervous system. World Health Organization, Geneva, pp. 43–45 (1979)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • M. Herbst

There are no affiliations available

Personalised recommendations