Indications and Experiences with the Ommaya-Reservoir for Treatment of CNS Neoplasms in Childhood
In 1974, an 11-year-old girl, suffering from acute lymphatic leukaemia (ALL), developed a symptomatic, non-resorptive, communicating hydrocephalus. A ventriculo-atrial CSF-drain-age-system (PHD) had to be inserted. During the following 36 months 13 recurrences of the leukaemic meningiosis were treated with Methotrexate and Cytosinarabinoside, administered intrathecally. The cytostatic drugs were injected into the frontal subcutaneous pump-device of the PHD.
After 86 punctures an infection with Staphylococcus epidermidis occurred. After treatment of the bacterial meningitis implantation of a contralateral Ommaya-System (O. S.). Because of left-sided focal Jacksonian epilepsy the position of the Ommaya device was corrected. Until the child’s death 11 months later intrathecal cytostatic therapy with a total of 59 punctures was well tolerated without any complications.
KeywordsAcute Myeloid Leukaemia Cytostatic Drug Ommaya Reservoir Intraventricular Administration Acute Lymphatic Leukaemia
Unable to display preview. Download preview PDF.
- 6.Goedhart, Z. D.: Het Ommaya system. Ph. D. Thesis. Leiden (1978)Google Scholar
- 11.Shapiro, W. R., Posner, J. B., Ushio, Y., Chernik, N. L., Young, D. F.: Treatment of meningeal neoplasms. Cancer Treatm. Rep. 61, 733–743 (1977)Google Scholar
- 13.Spiers, A. S. D.: Chemotherapy of acute leukaemia. Clin. Haematology 2, 127–164 (1972)Google Scholar