Indications and Experiences with the Ommaya-Reservoir for Treatment of CNS Neoplasms in Childhood

  • K. Roosen
  • W. Havers
  • J. Schaaf


The following case history demonstrates in an exemplary manner the advantages and disadvantages of the CSF-reservoir system published by Ommaya in 1963 [8]:
  • In 1974, an 11-year-old girl, suffering from acute lymphatic leukaemia (ALL), developed a symptomatic, non-resorptive, communicating hydrocephalus. A ventriculo-atrial CSF-drain-age-system (PHD) had to be inserted. During the following 36 months 13 recurrences of the leukaemic meningiosis were treated with Methotrexate and Cytosinarabinoside, administered intrathecally. The cytostatic drugs were injected into the frontal subcutaneous pump-device of the PHD.

  • After 86 punctures an infection with Staphylococcus epidermidis occurred. After treat­ment of the bacterial meningitis implantation of a contralateral Ommaya-System (O. S.). Because of left-sided focal Jacksonian epilepsy the position of the Ommaya device was corrected. Until the child’s death 11 months later intrathecal cytostatic therapy with a total of 59 punc­tures was well tolerated without any complications.


Acute Myeloid Leukaemia Cytostatic Drug Ommaya Reservoir Intraventricular Administration Acute Lymphatic Leukaemia 
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  1. 1.
    Blasberg, R. G., Patlak, C. S., Shapiro, W. R.: Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration. Cancer Treat. Rep. 61, 633–641 (1977)PubMedGoogle Scholar
  2. 2.
    Bleyer, W. A., Pizzo, Ph. A., Spence, A. M., Platt, W. D., Benjamin, D. R., Kolins, J., Poplack, D. G.: The Ommaya-Reservoir. Newly recognized complications and recommendations for insertion and use. Cancer 41, 2431–2437 (1978)PubMedCrossRefGoogle Scholar
  3. 3.
    Diamond, R. D., Bennett, J. E.: A Subcutaneous reservoir for intrathecal therapy of fungal meningitis. New Engl. J. Med. 288, 186–188 (1973)PubMedCrossRefGoogle Scholar
  4. 4.
    Fox, J. L.: Intermittent drainage of intracranial cyst via the subcutaneous Ommaya reservoir. J. Neurosurg. 27, 272–273 (1967)PubMedCrossRefGoogle Scholar
  5. 5.
    Galicich, J. H., Guido, L. J.: Ommaya device in carcinomatous and leukemic meningitis. Surg. Clin. North Am. 54, 915–922 (1974)PubMedGoogle Scholar
  6. 6.
    Goedhart, Z. D.: Het Ommaya system. Ph. D. Thesis. Leiden (1978)Google Scholar
  7. 7.
    Goedhart, Z. D., Hekster, R. E. M., Matricali, B.: Neurosurgical and neurological applications of the Ommaya reservoir system. Adv. Neurosurg. 6, 45–47 (1978)CrossRefGoogle Scholar
  8. 8.
    Ommaya, A. K.: Subcutaneous reservoir and pump for sterile access to ventricular cerebrospinal fluid. Lancet 2, 983–984 (1963)CrossRefGoogle Scholar
  9. 9.
    Ratcheson, R. A., Ommaya, A. K.: Experience with the subcutaneous CSF reservoir. New Engl. J. Med. 279, 1025–1031 (1968)PubMedCrossRefGoogle Scholar
  10. 10.
    Shapiro, W. R., Young, D. F., Mehta, B. M.: Methotrexate: Distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. N. Engl. J. Med. 293, 161–166 (1975)PubMedCrossRefGoogle Scholar
  11. 11.
    Shapiro, W. R., Posner, J. B., Ushio, Y., Chernik, N. L., Young, D. F.: Treatment of meningeal neoplasms. Cancer Treatm. Rep. 61, 733–743 (1977)Google Scholar
  12. 12.
    Spiers, A. S. D., Firth, J. L.: Treating the nervous system in acute leukaemia. Lancet 1, 433 (1972)PubMedCrossRefGoogle Scholar
  13. 13.
    Spiers, A. S. D.: Chemotherapy of acute leukaemia. Clin. Haematology 2, 127–164 (1972)Google Scholar

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© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • K. Roosen
  • W. Havers
  • J. Schaaf

There are no affiliations available

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