In recent years, several studies have shown that diet-induced proliferative uncomplicated atherosclerotic lesions regress after removal of the dietary stimulus Such regression has been reported in monkeys (Armstrong et al., 1970; Tucker et al., 1971; Vesselinovitch et al., 1973), chickens (Pick et al., 1952; Horlick and Katz, 1949), pigeons (Clarkson et al., 1971; St. Clair et al., 1972), and dogs (Bevans et al., 1951; De Palma et al., 1970). In rabbits, however, regression of artherosclerotic lesions appears to occur only when lesions are produced by cholesterol feeding for a short period (Bortz, 1968). No appreciable regression of artherosclerotic lesions has been reported in rabbits when cholesterol was fed for a long period (Friedman and Byers, 1963; Prior and Ziegler, 1965). In many instances, withdrawal of the dietary stimulus was followed by further progression of the disease (Constantinides, 1965).
KeywordsAtherosclerotic Lesion Regression Group High Cholesterol Diet Baseline Group Cholesterol Feeding
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