Evaluation of animals for use in studies of atherosclerosis has been on ongoing activity at our institution for a number of years, with some emphasis being given to primate species during the past 10 years. These evaluations have included studies of both naturally occurring and induced atherosclerosis, characterization of plasma lipoproteins, and studies of lipid metabolism. The purpose of this paper is to present our observations on diet-induced aortic atherosclerosis of nonhuman primates and to compare these lesions with those found in human beings. These observations include information on the characteristics, distribution, and extent of aortic lesions in nine species of monkeys as well as their aortic cholesterol and calcium concentrations.
KeywordsAbdominal Aorta Thoracic Aorta Aortic Calcium Fatty Streak Atherogenic Diet
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