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The Major Histocompatibility System of the Rat (Ag-B or H-1 System)

  • Chapter
The Major Histocompatibility System in Man and Animals

Abstract

The experimental use of the laboratory rat, Rattus norvegicus (Robinson 1965), resembles in general that of the laboratory mouse, Mus musculus. Both species belong to different genera in the family of Muridae.

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References

  • Aizawa, M., Itakura, K., and Katagiri, H. Serologic studies on the histocompatibility hemaggluti-nogen R-factor of the rat. Jap. J. Transplants. 1:82, 1965.

    Google Scholar 

  • Andersson, L.C., Binz, H., and Wigzell, H. Specific unresponsiveness to transplantation antigens induced by auto-immunization with syngeneic, antigen-specific T lymphoblasts. Nature 264:778–780, 1976.

    Google Scholar 

  • Armerding, D., Katz, D. H., and Benacerraf, B. Immune response genes in inbred rats. I. Analysis of responder status to synthetic polypeptides and low doses of bovine serum albumin. Immunogenetics 1:329–339, 1974a.

    Google Scholar 

  • Armerding, D., Katz, D. H., and Benacerraf, B. Immune response genes in inbred rats. II. Segregation studies of the GT and GA genes and their linkage to the major histocompatibility locus. Immunogenetics 1:340–351, 1974b.

    Google Scholar 

  • Arnason, B. G., Jankovic, B. D., Waksman, B. H., and Wennersten, C. Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte. J. Exp. Med. 116:177–186, 1962.

    PubMed  CAS  Google Scholar 

  • Artzt, K., and Bennett, D. Analogies between embryonic (T/t) antigens and adult major histo-compatibility (H-2) antigens. Nature 256:545–547, 1975.

    PubMed  CAS  Google Scholar 

  • Bansal, S. C., Hellström, I., Hellström, K. E., and Wright, P. W. Cell-mediated immunity and blocking serum activity before and after breakage of allograft tolerance in rats. Transplantation 16:610–620, 1973a.

    PubMed  CAS  Google Scholar 

  • Bansal, S. C., Hellström, K. E., Hellström, L, and Sjögren, H. O. Cell-mediated immunity and blocking serum activity to tolerated allografts in rats. J. Exp. Med. 137:590–602, 1973b.

    PubMed  CAS  Google Scholar 

  • Barker, C. F., and Billingham, R. E. Comparison of fates of Ag-B locus compatible homografts of skin and hearts in inbred rats. Nature 225:851–852, 1970.

    PubMed  CAS  Google Scholar 

  • Beer, A. E., Billingham, R. E., and Yang, S. L. Maternally induced transplantation immunity, tolerance, and runt disease in rats. J. Exp. Med. 135:808–826, 1972.

    PubMed  CAS  Google Scholar 

  • Beer, A. E., Scott, J. R., and Billingham, R. E. Histocompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents. J. Exp. Med. 142:180–196, 1975.

    PubMed  CAS  Google Scholar 

  • Benacerraf, B., and Katz, D. H. The nature and function of histocompatibility-linked immune response genes. In B. Benacerraf (ed.), Immunogenetics and Immunodeficiency, pp. 117–177, Medical and Technical Publishing Co., St. Leonard’s House, Lancaster, 1975.

    Google Scholar 

  • Bernstein, I. D., and Wright, P. W. Generation of cytotoxic lymphocytes in mixed leukocyte culture by rat lymphoid cells. Transplantation 21:173–178, 1976.

    PubMed  CAS  Google Scholar 

  • Bildsøe, P., Sørensen, S. F., Petirossi, O., and Simonsen, M. Heart and kidney transplantation from segregating hybrid to parental rats. Transplant. Rev. 3:36–45, 1970.

    Google Scholar 

  • Bildsøe, P. Organ transplantation in the rat. The importance of the Ag-B (or H-1) locus. Acta Pathol. Microbiol. Scand. (Section B) 80:221–230, 1972.

    Google Scholar 

  • Billingham, R. E., Brent, L., and Medawar, P. B. Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Phil. Trans. Soc. London (B) 239:357–414, 1956.

    Google Scholar 

  • Billingham, R. E., Defendi, V., Silvers, W. R., and Steinmuller, D. Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats. J. Nat. Cancer Inst. 28:365–435, 1962a.

    PubMed  CAS  Google Scholar 

  • Billingham, R. E., Hodge, B. A., and Silvers, W. K. An estimate of the number of histocompatibility loci in the rat. Proc. Natl. Acad. Sci. (USA) 48:138–147, 1962b.

    CAS  Google Scholar 

  • Binz, H., and Askonas, B. A. Inhibition of mixed leukocyte culture by anti-idiotypic antibodies. Eur. J. Immunol. 5:618–623, 1975.

    PubMed  CAS  Google Scholar 

  • Binz, H., Lindenmann, J., and Wigzell, H. Inhibition of local graft-versus-host reaction by anti-alloantibodies. Nature 246:146–148, 1973.

    PubMed  CAS  Google Scholar 

  • Binz, H., Lindenmann, J., and Wigzell, H. Cell-bound receptors for alloantigens on normal lymphocytes. II. Anti-alloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes. J. Exp. Med. 140:731–741, 1974.

    PubMed  CAS  Google Scholar 

  • Binz, H., and Wigzell, H. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T cell receptors with specificity for the same alloantigens. J. Exp. Med. 142:197–211, 1975a.

    PubMed  CAS  Google Scholar 

  • Binz, H., and Wigzell, H. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization. J. Exp. Med. 142:1218–1230, 1975b.

    PubMed  CAS  Google Scholar 

  • Binz, H., and Wigzell, H. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. III. Physical fractionation of specific immunocompetent T lymphocytes by affinity chromatography using anti-idiotypic antibodies. J. Exp. Med. 142:1231–1240, 1975c.

    PubMed  CAS  Google Scholar 

  • Binz, H., and Wigzell, H. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. IV. Isolation of two groups of naturally occuring, idiotypic molecules with specific antigen-binding activity in the serum and urine of normal rats. Scand. J. Immunol. 4:591–600, 1975d.

    PubMed  CAS  Google Scholar 

  • Binz, H., and Wigzell, H. Specific transplantation tolerance induced by autoimmunization against the individual’s own naturally occuring idiotypic, antigen-binding receptors. J. Exp. Med. 144:1438–1457, 1976.

    PubMed  CAS  Google Scholar 

  • Binz, H., Wigzell, H., and Bazin, H. T-cell idiotypes are linked to immunoglobulin heavy chain genes. Nature 264:639–642, 1976.

    PubMed  CAS  Google Scholar 

  • Bitter-Suermann, H. Survival of unmodified spleen allografts in rats. Nature 147:465–466, 1974a.

    Google Scholar 

  • Bitter-Suermann, H. Different ways of using graft-versus-host reactivities to achieve acceptance of rat spleen allografts in the same donor-recipient pairing. Transplantation 18:515–519, 1974b.

    PubMed  CAS  Google Scholar 

  • Bogden, A. E., and Aptekman, P. M. The “R-1” factor a histocompatibility antigen in the rat. Cancer Res. 20:1272–1282, 1960.

    Google Scholar 

  • Borovská, M., Kořínek, J., Václavíková, I., and Démant, P. Ss protein: Search for cross-reacting substances in different species. Folia biol. (Praha) 17:283–285, 1971.

    Google Scholar 

  • Bruce, J., Golstein, P., and Mitchison, N. A. Allogenic cytotoxic response by rat cells in vitro. Transplantation 20:88–92, 1975.

    PubMed  CAS  Google Scholar 

  • Burhoe, S. O. Blood groups of the rat (Rattus norvegicus) and their inheritance. Proc. Natl. Acad. Sci. (USA) 33:102–109, 1947.

    CAS  Google Scholar 

  • Callahan, G. N., and De Witt, C. W. Rat cell surface antigens. I. Isolation and partial characterization of an Ag-B antigen. J. Immunol 114:776–778, 1975.

    PubMed  CAS  Google Scholar 

  • Colley, D. G., and DeWitt, C. W. Mixed lymphocyte blastogenesis in response to multiple histocompatibility antigens. J. Immunol 102:107–116, 1969.

    PubMed  CAS  Google Scholar 

  • Committee for a Standardized Karyotype of Rattus norvegicus. Standard karyotype of the Norway rat, Rattus norvegicus. Cytogenet. Cell Genet. 12:199–205, 1973.

    Google Scholar 

  • Cramer, D. V., Shonnard, J. W., and Gill, T. J., III. Genetic studies in inbred rats. II. Relationship between the major histocompatibility complex and mixed lymphocyte reactivity. J. Immunogenet. 1:421–428, 1974.

    Google Scholar 

  • Cramer, D. V., Shonnard, J. W., Davis, B. K., and Gill, T. J., III. Polymorphism of the mixed lymphocyte response of wild norway rats. Transplant. Proc. 9:559–562, 1977.

    PubMed  CAS  Google Scholar 

  • Curman, B., Östberg, L., Sandberg, L., Malmheden-Eriksson, I., Stalenheim, G., Rask, L., and Peterson, P. H-2 linked Ss protein is C4 component of complement. Nature 258:243–245, 1975.

    PubMed  CAS  Google Scholar 

  • Davies, D. A. L., and Alkins, B. J. What abrogates heart transplant rejection in immunological enhancement? Nature 247:294–297 (1974).

    PubMed  CAS  Google Scholar 

  • Davies, D. A. L., and Hess, M. Isolation and partial characterization of a new alloantigen genetically linked to the major histocompatibility locus of the mouse. Nature 250:228–230, 1974.

    PubMed  CAS  Google Scholar 

  • DeWitt, C. W., and McCullough, M. Ag-F: Serological and genetic identification of a new locus in the rat governing lymphocyte membrane antigens. Transplantation 19:310–317, 1975.

    PubMed  CAS  Google Scholar 

  • Dorf, M. E., Balner, H., and Benacerraf, B. Mapping of the immune response genes in the major histocompatibility complex of the rhesus monkey. J. Exp. Med. 142:673–693, 1975.

    PubMed  CAS  Google Scholar 

  • Dorsch, S., and Roser, B. The clonal nature of allo-antigen-sensitive small lymphocytes in the recirculating pool of normal rats. Aust. J. Exp. Biol Med. Sci. 52:45–66, 1974.

    PubMed  CAS  Google Scholar 

  • Dunn, L. C., Gluecksohn-Schoenheimer, S., Curtis, M. R., and Dunning, W. F. Heredity and accident as factors in the production of taillessness in the rat. J. Hered. 33:65–67, 1942.

    Google Scholar 

  • Elkins, W. L. Invasion and destruction of homologous kidney by locally inoculated lymphoid cells. J. Exp. Med. 120:329–347, 1964.

    PubMed  CAS  Google Scholar 

  • Elkins, W. L., Hellström, I., and Hellström, K. E. Transplantation tolerance and enhancement. Concepts and questions. Transplantation 18:38–45, 1974.

    PubMed  CAS  Google Scholar 

  • Elkins, W. L., and Palm, J. Identification of a single strong histocompatibility locus in the rat by normal spleen-cell transfer. Ann. N.Y. Acad. Sci. 129:573–580, 1966.

    Google Scholar 

  • Elves, M. W. The mixed lymphocyte reaction in inbred strains of rats. Vox Sang. 13:7–11-1967.

    PubMed  CAS  Google Scholar 

  • Elves, M. W. The mixed leucocyte reaction. II A comparison of the MLR with skin graft survival and serological methods of detecting H-antigens using F2 generation rats. Transplantation 8:757–762, 1969.

    Google Scholar 

  • Fabre, J. W., and Morris, P. J. Passive enhancement of homozygous renal allografts in the rat. Transplantation 18:429–435, 1974a.

    PubMed  CAS  Google Scholar 

  • Fabre, J. W., and Morris, P. J. Passive enhancement of rat renal allografts with only partial cover of the incompatible Ag-B specificities. Transplantation 18:436–442, 1974b.

    PubMed  CAS  Google Scholar 

  • Fabre, J. W., and Morris, P. J. The definition of a lymphocyte-specific alloantigen system in the rat (Ly-1). Tissue Antigens 4:238–246, 1974c.

    PubMed  CAS  Google Scholar 

  • Fabre, J. W., and Morris, P. J. Studies on the specific suppression of renal allograft rejection in presensitized rats. Theoretical and clinical implications. Transplantation 19:121–133, 1975.

    PubMed  CAS  Google Scholar 

  • Feldman, J. D., Pick, E., Lee, S., Silvers, W. K., and Wilson, D. C. Renal homotransplantation in rats. II. Tolerant recipients. Am. J. Pathol. 52:687–700, 1968.

    PubMed  CAS  Google Scholar 

  • Festenstein, H. Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant. Proc. 15:62–88, 1973.

    CAS  Google Scholar 

  • Festing, M. W. F., and Butler, W. International Index of Laboratory Animals. Medical Research Council, Laboratory Animals Center, Carshalton, UK, 1975.

    Google Scholar 

  • Festing, M. F. W., and Staats, J. Standardized nomenclature of inbred strains of rats. Fourth listing. Transplantation 16:221–245, 1973.

    Google Scholar 

  • Ford, W. L. A local graft-versus-host reaction following intradermal injection of lymphocytes in the rat. Br. J. Exp. Pathol. 48:335–345, 1967.

    PubMed  CAS  Google Scholar 

  • Ford, W. L. Lymphoid cell kinetics in graft-versus-host reactions and allograft rejection. In R. Calne (ed.), Immunological Aspects of Transplantation surgery-pp. 39–66, Medical and Technical Publishing Co. St. Leonard’s House, Lancaster, 1973.

    Google Scholar 

  • Ford, W. L., and Atkins, R. C. Specific unresponsiveness of recirculating lymphocytes after exposure to histocompatibility antigen in F1 hybrid rats. Nature New Biol. 234:178–180, 1971.

    PubMed  CAS  Google Scholar 

  • Ford, W. L., Burr, W., and Simonsen, M. A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation 10:258–266, 1970.

    PubMed  CAS  Google Scholar 

  • Ford, W. L., Simmonds, S. J., and Atkins, R. C. Early cellular events in a systemic graft-versus-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex. J. Exp. Med. 141:681–696, 1975.

    PubMed  CAS  Google Scholar 

  • Ford, W. L., and Simonsen, M. The factor of immunization in the rat. The effect of allogeneic immunization on graft-versus-host activity. J. Exp. Med. 133:938–949, 1971.

    PubMed  CAS  Google Scholar 

  • Freeman, J. S., and Steinmuller, D. Acute rejection of skin and heart allografts in rats matched at the major histocompatibility locus. Transplantation 8:530–533, 1969.

    PubMed  CAS  Google Scholar 

  • Frelinger, J. A., Niederhuber, J. E., David, C. S., and Shreffler, D. C. Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes. J. Exp. Med. 140:1273–1284, 1974.

    PubMed  CAS  Google Scholar 

  • Frelinger, J. A., and Shreffler, D. C. The major histocompatibility complexes. In B. Benacerraf (ed.), Immunogenetics and Immunodeficiency-pp. 81–116, Medical and Technical Publishing Co., St. Leonhard’s House, Lancaster, 1975.

    Google Scholar 

  • French, M. E., and Batchelor, J. R. Immunological enhancement of rat kidney grafts. Lancet II:1103–1106, 1969.

    Google Scholar 

  • French, M. E., and Batchelor, J. R. Enhancement of renal allografts in rats and man. Transplant. Rev. 13:115–141, 1972.

    PubMed  CAS  Google Scholar 

  • Gasser, D. L., Newlin, C. M., Palm, J., and Gonatas, N. K. Genetic control of susceptibility to experimental allergic encephalomyelitis in rats. Science 181:872–873, 1973a.

    PubMed  CAS  Google Scholar 

  • Gasser, D. L., Palm, J., and Gonatas, N. K. Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J. Immunol. 115:431–433, 1975.

    PubMed  CAS  Google Scholar 

  • Gasser, D. L., and Silvers, W. K. Genetic determinants of immunological responsiveness. Adv. Immunol. 18:1–66, 1974.

    PubMed  CAS  Google Scholar 

  • Gasser, D. L., Silvers, W. K., Reynolds, H. M., Jr., Black, G., and Palm, J. Serum esterase genetics in rats: Two new alleles at Es-2, a new esterase regulated by hormonal factors, and linkage of these loci to the Ag-C blood group locus. Biochem. Genet. 10:207–217, 1973b.

    PubMed  CAS  Google Scholar 

  • Gill, T. J., III, and Kunz, H. W. Genetic and cellular factors in the immune response. II. Evidence for the polygenic control of the antibody response from further breeding studies and from pedigree analyses. J. Immunol. 106:980–992, 1971.

    PubMed  CAS  Google Scholar 

  • Gill, T. J., III, and Kunz, H. W. Genetic studies in inbred rats. VII. Tentative model for the major histocompatibility complex. J. Immunogenetics 3:139–143, 1976.

    Google Scholar 

  • Gill, T. J., III, Kunz, H. W., Cramer, D. V., and Shonnard, J. Studies on the major histocompatibility complex of genetically inbred rats. In V. P. Eijsvoogel, D. Roos, W. P. Zeijlemaker (eds.), Leukocyte Membrane Determinants Regulating Immune Reactivity-p. 511, Academic Press, New York, 1976.

    Google Scholar 

  • Gordon, R. O., Stinson, E. B., Souther, S. G., and Oppenheim, J. J. Inhibition of the mixed leukocyte reaction as an assay for enhancing alloantiserum. Transplantation 12:484–489, 1971.

    PubMed  CAS  Google Scholar 

  • Gorer, P.A., and Mikulska, Z.B. The antibody response to tumor inoculation: Improved methods of antibody detection. Cancer Res. 14:651–655, 1954.

    PubMed  CAS  Google Scholar 

  • Gronemeyer, U., and Müller-Ruchholtz, W. Allogene Hornhauttransplantation bei Inzuchtratten, IV. Bedeutung des Histoinkompatibilitätsgrades zwischen Spender und Empfänger. Albrecht von Graefes Arch. Klin. Ophthalmol. 190:309–317, 1974.

    CAS  Google Scholar 

  • Günther, E., and Bhakdi-Lehnen, B. Inhibition of rat lymphocyte function in vitro by alloan-tisera. In V. P. Eijsvoogel, D. Roos, W. P. Zeijlemaker (eds.), Leukocyte Membrane Determinants Regulating Immune Reactivity-pp. 405–414, Academic Press, New York, 1976.

    Google Scholar 

  • Günther, E., Mozes, E., Rüde, E., and Sela, M. Genetic control of immune responsiveness to poly(LPro)—poly(LLys) derived polypeptides by histocompatibility-linked immune response genes in the rat. J. Immunol 117:2047–2052, 1976.

    PubMed  Google Scholar 

  • Günther, E., Odenthal, H., and Wechsler, W. Immunogenetics of EAE in rats. International Workshop: “Myelin Biology”-Abstracts, pp. 101–105, 1975.

    Google Scholar 

  • Günther, E., and Rüde, E. Genetic complementation of histocompatibility-linked Ir genes in the rat. J. Immunol. 115:1387–1393, 1975.

    PubMed  Google Scholar 

  • Günther, E., and Rüde, E. Cross-stimulation of antigens under separate histocompatibility-linked Ir gene control. Immunogenetics 3:261–269, 1976.

    Google Scholar 

  • Günther, E., Rüde, E., and Hedrich, H.J. Complex structure of the major histocompatibility system of the rat. Transplant. Proc. 7 (Suppl. 1): 147–150, 1975.

    Google Scholar 

  • Günther, E., Rüde, E., Meyer-Delius, M., and Štark, O. Immune response genes linked to the major histocompatibility system in the rat. Transplant. Proc. 5:1467–1469, 1973.

    PubMed  Google Scholar 

  • Günther, E., Rüde, E., and Štark, O. Antibody response in rats to the synthetic polypeptide (T,G)-A-L genetically linked to the major histocompatibility system. Eur. J. Immunol. 2:151–155, 1972.

    PubMed  Google Scholar 

  • Gutman, G. A., Loh, E., and Hood, L. Structure and regulation of immunoglobulins: Kappa allotypes in the rat have multiple amino acid differences in the constant region. Proc. Natl. Acad. Sci. (USA) 72:5046–5050, 1975.

    CAS  Google Scholar 

  • Hammerberg, C., and Klein, J. Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature 258:296–299, 1975.

    PubMed  CAS  Google Scholar 

  • Hausman, S. J., and Palm, J. Variable expression of Ag-B and non-Ag-B histocompatibility antigens on cultured rat cells of different histological origin. Transplantation 16:313–324, 1973.

    PubMed  CAS  Google Scholar 

  • Heslop, B. F. Histocompatibility antigens in the rat: The AS2 strain in relation to the AS, BS and HS strains. Aust. J. Exp. Biol. Med. Sci. 46:479–491, 1968.

    PubMed  CAS  Google Scholar 

  • Heyner, S. The significance of the intercellular matrix in the survival of cartilage allografts. Transplantation 8:666–677, 1969.

    PubMed  CAS  Google Scholar 

  • Howard, J. C., and Scott, D.C. The identification of sera distinguishing marrow-derived and thymus-derived lymphocytes in the rat. Immunology 27:903–922, 1974.

    PubMed  CAS  Google Scholar 

  • Hughes, R. A. C., and Stedronska, J. The susceptibility of rat strains to experimental allergic encephalomyelitis. Immunology 24:879–884, 1973.

    PubMed  CAS  Google Scholar 

  • Ippolito, R. J., Mahoney, R. J., and Murray, I. M. Renal transplantation between histoincom-patible rats. I. Acute rejection and prolonged survival of reciprocal renal allografts in immunocompetent rats. Transplantation 14:183–190, 1972.

    PubMed  CAS  Google Scholar 

  • Iványi, D. The role of the major histocompatibility system in tooth germ transplantation of the rat. Transplantation 6:594–591, 1968.

    PubMed  Google Scholar 

  • Iványi, P. Serological production of congenic lines in rats. In Polymorphismes biochemiques des Animaux-pp. 507–510, Ed. Inst. National de la Recherche Agronomique, Paris, 1967.

    Google Scholar 

  • Jay, G. E., Jr. Genetic strains and stocks II. Rats. In W. J. Burdette (ed.), Methodology in Mammalian Genetics-pp. 104–111, Holden-Day, San Francisco, 1973.

    Google Scholar 

  • Johnston, J. M., and Wilson, D. B. Origin of immunoreactive lymphocytes in rats. Cell. Immunol. 1:430–444, 1970.

    PubMed  CAS  Google Scholar 

  • Katagiri, M., Natori, T., Tanagaki, N., Kreiter, V. P., and Pressman, D. Papain-solubilized Ag-B antigens. I. Isolation and characterization of two components composing Ag-B antigens. Transplantation 19:230–239, 1975a.

    PubMed  CAS  Google Scholar 

  • Katagiri, M., Tanigaki, N., and Pressman, D. Papain-solubilized Ag-B-antigens. II. Characterization of small sized Ag-B molecules. Transplantation 20:135–141, 1975b.

    PubMed  CAS  Google Scholar 

  • Klein, J. Biology of the mouse histocompatibility-2 complex. Springer-Verlag, New York, 1975.

    Google Scholar 

  • Koch, C. Inheritance in the rat of antibody response to two different determinants of (T,G)-A—L. Immunogenetics 1:118–125, 1974.

    Google Scholar 

  • Kohne, D. E. Evolution of higher-organism DNA. Quart. Rev. Biophys. 3:327–375, 1970.

    CAS  Google Scholar 

  • Křen, V. The major histocompatibility system (H-1) alleles of some british rat strains. Transplantation 17:148–152, 1974.

    PubMed  Google Scholar 

  • Křen, V., Brdicka, R., and Štark, O. Erythrocyte and transplantation antigens in inbred strains of rats. VIII. The dynamics of 19S and 7S LEW anti-H-1 haemagglutinin production. Folia biol. (Praha) 14:274–285, 1968.

    Google Scholar 

  • Křen, V., Křenová, D., and Štark, O. Runt syndrome incidence and skin graft tolerance in various interstrain combinations of rats differing at a single or multiple histocompatibility loci. Folia Biol. (Praha) 16:305–313, 1970.

    Google Scholar 

  • Křen, V., Sachs, J. A., and Bishop, C. E. Studies on the homology between human and rat MHS. I. Allogeneic effect of xenogeneic rat antihuman immunization. Folia Biol (Praha) 22:60–61, 1976.

    Google Scholar 

  • Křen, V., Štark, O., Bíla, V., Frenzl, B., Kíenová, D., and Kršiaková, M. Rat alloantigenic systems defined through congenic strain production. Transplant. Proc. 5:1463–1466, 1973.

    PubMed  Google Scholar 

  • Křen, V., Štark, O., and Křenová, D. Tolerance manifestation among inbred rat strains defined in the Rt H-1 antigens. I. Runt syndrome and skin graft tolerance. Folia Biol. (Praha) 15:188–196, 1969.

    Google Scholar 

  • Kfen, V., Vesely, P., Frenzl, B., and Stark, O. Inhibition of the runting syndrome in rats. Folia biol. (Praha) 6:333–341, 1960.

    Google Scholar 

  • Křenová, D., Kfen, V., and Štark, O. Properties of the rat tumour Fedex-WP during long-term cultivation in vitro. Neoplasma 15:379–392, 1967.

    Google Scholar 

  • Křenová, D., Křen, V., and Štark, O. Properties of spontaneous rat mammary carcinoma CaM-LEW. II. Karyological characteristics and antigenic properties of CaM-LEW tumour, long-term passaged in vivo and in vitro. Neoplasma 16:523–530, 1969.

    PubMed  Google Scholar 

  • Křenová, D., Kfen, V., and Štark, O. Properties of the sarcomas induced by Ferridextran Spofa in inbred rat strain AVN. II. The observation of H-1a and B 1 antigenicity of FEDEX-AVN/3 tumour following long term in vitro cultivation. Neoplasma 17:505–512, 1970a.

    PubMed  Google Scholar 

  • Křenová, D., Křen, V., and Štark, O. H-1 antigenicity of rat tumours after in vivo passage and in vitro cultivation. In Proceedings of the XIth European Conference on Animal Blood Groups, Biochemistry and Polymorphism-pp. 557–560. Ed. E.S.A.B.R., PWN-Polish Scient. Publ., Warsaw, 1970b.

    Google Scholar 

  • Křenová, D., Kren, V., and Štark, O. The detection of alloantigens on rat tumour cells in vitro by membrane immunofluorescence. Ann. Blood Groups Biochem. Genet., Suppl. 1; p. 85, 1972.

    Google Scholar 

  • Kunz, H. W., and Gill, T. J., III. Genetic studies in inbred rats. I. Two new histocompatibility alleles. J. Immunogenet. 1:413–420, 1974a.

    Google Scholar 

  • Kunz, H. W., and Gill, T. J., III. The effects of antigenic isomerism and antigenic aggregation on the antibody response in inbred rats. J. Immunogenet. 1:289–294, 1974b.

    CAS  Google Scholar 

  • Kunz, H. W., Gill, T. J., III, and Borland, B. The genetic linkage of the immune response to poly (Glu52Lys33Tyr15) to the major histocompatibility locus in inbred rats. J. Immunogenet. 1:277–287, 1974.

    CAS  Google Scholar 

  • Kunz, H. W., Gill, T. J., III, Hansen, C. T., and Poloskey, P. E. Genetic studies in inbred rats. III. Histocompatibility type and immune response of some mutant stocks. J. Immunogenet. 2:51–54, 1975.

    Google Scholar 

  • Lachmann, P. J., Grennan, D., Martin, A., and Demant, P. Identification of Ss protein as murine C4. Nature 258:242–243, 1975.

    PubMed  CAS  Google Scholar 

  • Laird, C. D., MacConaughty, B. L., and McCarthy, B. J. Rate of fixation of nucleotide substitutions in evolution. Nature 224:149–154, 1969.

    PubMed  CAS  Google Scholar 

  • Lamm, L. U., Svejgaard, A., and Kissmeyer-Nielsen, F. PGM3-HL-A is another linkage in man. Nature New Biol. 231:109–110, 1971.

    PubMed  CAS  Google Scholar 

  • Larner, B. J., and Fitch, F. W. Inhibition of rat mixed lymphocyte culture by hyperimmune alloantiserum. Lack of correlation with allograft-enhancing activity. Transplantation 16:54–57, 1973.

    PubMed  CAS  Google Scholar 

  • Lee, S. An improved technique of renal transplantation in the rat. Surgery 61:771–773, 1967.

    PubMed  CAS  Google Scholar 

  • Lee, S., and Edgington, T. S. Heterotopic liver transplantation utilizing inbred rat strains. I. Characterization of allogeneic graft rejection and the effects of biliary obstruction and portal vein circulation on liver regeneration. Am. J. Pathol. 52:649–669, 1968.

    PubMed  CAS  Google Scholar 

  • Levine, S. Local and regional forms of a graft-versus-host disease in lymph nodes. Transplantation 6:799–802, 1968.

    PubMed  CAS  Google Scholar 

  • Levine, S., and Sowinski, R. Allergic encephalomyelitis in the reputedly resistant Brown Norway strain of rats. J. Immunol. 114:597–601, 1975.

    PubMed  CAS  Google Scholar 

  • Lubaroff, D. M. An alloantigenic marker on rat thymus and thymus-derived cells. Transplant. Proc. 1:115–118, 1973.

    Google Scholar 

  • Lucas, Z. J., Markley, J., and Travis, M. Immunologic enhancement of renal allografts in the rat. I. Dissociation of graft survival and antibody response. Fed. Proc. 29:2041–2047, 1970.

    PubMed  CAS  Google Scholar 

  • Luderer, A. A., Maurer, P. H., and Woodland, R. T. Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. J. Immunol. 117:1079–1084, 1976

    PubMed  CAS  Google Scholar 

  • Mahabir, R. N., Guttman, R. D., and Lindquist, R. R. Renal transplantation in the inbred rat. X. A model of “weak histoincompatibility” by major locus matching. Transplantation 8:369–378, 1969.

    PubMed  CAS  Google Scholar 

  • Mayr, W. R., Mayr, D., Kömpf, J., Bissbort, S., and Ritter, H. Possible linkage of HL-A and GLO. Human. Genet. 31:241–242, 1976.

    CAS  Google Scholar 

  • McKearn, T. J. Anti-receptor antiserum causes specific inhibition of reactivity to rat histocompatibility antigens. Science 183:94–96, 1974.

    PubMed  CAS  Google Scholar 

  • McKearn, T. J., Finnegan, A., Neu, M., Fitch, F. W., and Stuart, F. P. Suppression of rat renal allograft rejection by antibody against lymphocyte antigen receptors. Surg. Forum 25:263–265, 1974a.

    PubMed  CAS  Google Scholar 

  • McKearn, T. J., Hamada, Y., Stuart, F. P., and Fitch, F. W. Anti-receptor antibody and resistance to graft-versus-host disease. Nature 251:648–650, 1974b.

    PubMed  CAS  Google Scholar 

  • McKearn, T. J., Stuart, F. P., and Fitch, F. W. Anti-idiotypic antibody in rat transplantation immunity. I. Production of anti-idiotypic antibody in animals repeatedly immunized with alloantigens. J. Immunol. 113:1876–1882, 1974c.

    PubMed  CAS  Google Scholar 

  • Meo, T., Krasteff, T., and Shreffler, D. C. Immunochemical characterization of murine H-2 controlled Ss (serum substance) protein through identification of its homologue as the fourth component of complement. Proc. Natl. Acad. Sci. (USA) 72:4536–4540, 1975.

    CAS  Google Scholar 

  • Michie, D., and Anderson, N. F. A strong selective effect associated with a histocompatibility gene in the rat. Ann. N.Y. Acad. Sci. 129:88–93, 1966.

    Google Scholar 

  • Miller, C., and DeWitt, C. W. The effect of neonatal thymectomy on antibody responses to histocompatibility antigens in the rat. Cell. Immunol. 13:278–287, 1974.

    PubMed  CAS  Google Scholar 

  • Mitchell, M.S., Bove, J. R., and Calabresi, P. Simplified estimation of mouse isohemagglutinins by microassay. Transplantation 7:294–296, 1969.

    PubMed  CAS  Google Scholar 

  • Mozes, E., McDevitt, H. O., Jaton, J.-C., and Sela, M. The genetic control of antibody specificity. J. Exp. Med. 130:1263–1278, 1969.

    PubMed  CAS  Google Scholar 

  • Mullen, Y., and Hildemann, W. H. Kidney transplantation genetics and enhancement in rats. Transplant. Proc. 3:669–672, 1971.

    PubMed  CAS  Google Scholar 

  • Mullen, Y., and Hildemann, W. H. X-and Y-linked transplantation antigens in rats. Transplantation 13:521–529, 1972.

    PubMed  CAS  Google Scholar 

  • Nesbitt, M. N. Evolutionary relationships between rat and mouse chromosomes. Chromosoma 46:217–224, 1974.

    PubMed  CAS  Google Scholar 

  • Newlin, C. M., and Gasser, D. L. Genetic control of the in vitro responses of peripheral blood lymphocytes to phytohemagglutinin and concanavalin A. J. Immunol. 110:622–628, 1973.

    PubMed  CAS  Google Scholar 

  • Nowell, P. C., Finan, J. B., and Wilson, D. B. Proliferation in vitro of T lymphocytes reactive to histocompatibility alloantigens: a correction. J. Exp. Med. 142:230–235, 1975.

    PubMed  CAS  Google Scholar 

  • Owen, R. D. Earlier studies of blood groups in rats. Ann. N.Y. Acad. Sci. 97:37–42, 1962.

    PubMed  CAS  Google Scholar 

  • Palm, J. Current status of blood groups in rats. Ann. N.Y. Acad. Sci. 97:57–68, 1962.

    PubMed  CAS  Google Scholar 

  • Palm, J. Histocompatibility and linkage relationship of loci determining isoantigens of the rat. Proceedings of the XIth International Congress on Genetics 1:198, 1963.

    Google Scholar 

  • Palm, J. Serological detection of histocompatibility antigens in two strains of rats. Transplantation 2:603–612, 1964.

    PubMed  CAS  Google Scholar 

  • Palm, J. Maternal-fetal interactions and histocompatibility antigen polymorphisms. Transplant. Proc. 2:162–173, 1970a.

    PubMed  CAS  Google Scholar 

  • Palm, J. “Ontogeny” of the major histocompatibility locus in rats. A problem in nomenclature. Transplantation 9:161–163, 1970b.

    PubMed  CAS  Google Scholar 

  • Palm, J. Immunogenetic analysis of Ag-B histocompatibility antigens in rats, Transplantation 11:175–183, 1971.

    PubMed  CAS  Google Scholar 

  • Palm, J., and Black, G. Interrelationships of inbred rat strains with respect to Ag-B and non-Ag-B antigens. Transplantation 11:184–189, 1971.

    PubMed  CAS  Google Scholar 

  • Palm, J., and Wilson, D. B. The Ag-B locus of rats: A major histocompatibility complex? Transplant. Proc. 5:1573–1577, 1973.

    PubMed  CAS  Google Scholar 

  • Paris, A., Bishop, C., Festenstein, E., and Günther, E. Evidence for epistatic gene interaction in rat renal allograft rejection. Submitted for publication, 1976.

    Google Scholar 

  • Penhale, W. J., Farmer, A., Urbaniak, S. J., and Irvine, W. J. Susceptibility of inbred rat strains to experimental thyroiditis: Quantitation of thyroglobulin-binding cells and assessment of T-cell function in susceptible and non-susceptible strains. J. Clin. Exp. Immunol. 19:179–191, 1975.

    CAS  Google Scholar 

  • Poloskey, P. E., Kunz, H. W., and Gill, T. J., III. Genetic studies in inbred rats. V. Xenoantisera against two major histocompatibility antigens raised by immunization with red cells. J. Immunogenet. 2:189–193, 1975b.

    Google Scholar 

  • Poloskey, P. E., Kunz, H. W., Gill, T. J., III, Shonnard, J. W., Hansen, C. T., and Dixon, B. D. Genetic studies in inbred rats. IV. Xenoantisera against rat erythrocyte (Ag-C) antigens. J. Immunogenet. 2:179–187, 1975a.

    Google Scholar 

  • Ramseier, H. Antibodies to receptors recognizing histocompatibility antigens. Current Topics in Microbiology and Immunology 60:31–78, 1973.

    PubMed  CAS  Google Scholar 

  • Ramseier, H., and Lindenmann, J. Allotypic antibodies, Transplant. Rev. 10:57–96, 1972a.

    PubMed  CAS  Google Scholar 

  • Ramseier, H., and Lindenmann, J. Similarity of cellular recognition structures for histocompatibility antigens and of combining sites of corresponding alloantibodies. Eur. J. Immunol. 2:109–114, 1972b.

    PubMed  CAS  Google Scholar 

  • Ramseier, H., and Palm, J. Further studies of histocompatibility loci in rats. Transplantation 5:721–729, 1967.

    PubMed  CAS  Google Scholar 

  • Reckard, C. R., and Barker, C. F. Transplantation of isolated pancreatic islets across strong and weak histocompatibility barriers. Transplant. Proc. 5:761–763, 1973.

    PubMed  CAS  Google Scholar 

  • Robinson, R. Genetics of the Norway Rat. Pergamon Press, London, 1965.

    Google Scholar 

  • Robinson, R. Gene Mapping in Laboratory Mammals-Part B, pp. 365–396, Plenum Press, London, 1972.

    Google Scholar 

  • Rolstad, B., and Ford, W. L. Immune response of rats deficient in thymus-derived lymphocytes to strong transplantation antigens (Ag-B). Graft-versus-host activity, allograft rejection, and the factor of immunization. Transplantation 17:405–415, 1974.

    PubMed  CAS  Google Scholar 

  • Rolstad, B., Williams, A. F., and Ford, W. L. The alloantibody response to a strong transplantation antigen (Ag-B). Quantitative aspects and thymus dependence of the response. Transplantation 17:416–423, 1974.

    PubMed  CAS  Google Scholar 

  • Rose, N. R. Differing responses of inbred rat strains in experimental autoimmune thyroiditis. Cell. Immunol. 18:360–364, 1975.

    PubMed  CAS  Google Scholar 

  • Rüde, E., and Günther, E. Genetic control of the immune response to synthetic polypeptides in rats and mice. Prog. Immunol. II, 2:223–233, 1974.

    Google Scholar 

  • Sachs, J. A., and Křen, V. Studies on the homology between human and rat MHS. II Cytotoxic action of congenic rat alloimmune H-1 sera with human lymphocytes. Folia Biol. (Praha) 22:62–64, 1976.

    Google Scholar 

  • Sakai, A. Antigenicity of skin and kidney in the rat, as studied in a transplantation model. Transplantation 8:882–889, 1969.

    Google Scholar 

  • Salaman, J.R. Prolonged survival of renal allografts in rats mismatched at the major histocompatibility locus. Transplantation 11:63–70, 1971.

    PubMed  CAS  Google Scholar 

  • Sarich, V. M. Generation time and albumin evolution. Biochem. Genet. 7:205–212, 1972.

    PubMed  CAS  Google Scholar 

  • Shonnard, J. W., Cramer, D. V., Poloskey, P. E., Davis, B. K., and Gill, T. J., III. Genetic studies in inbred rats. VI. Linkage relationships of mixed lymphocyte reactivity, serologically defined antigens (Ag-B, Ag-C) and the immune response to poly (Glu52Lys33Tyr15). J. Immunogenetics 3:61–70, 1976.

    CAS  Google Scholar 

  • Shonnard, J. W., Cramer, D. V., Poloskey, P. E., Kunz, H. W., and Gill, T. J., III. Polymorphism of the major histocompatibility locus in the wild Norway rat. Immunogenetics 3:193–200, 1976.

    Google Scholar 

  • Shreffler, D. C., and David, C. S. The H-2 major histocompatibility complex and the I immune response region: Genetic variation, function and organization. Adv. Immunol. 20:125–195, 1975.

    PubMed  CAS  Google Scholar 

  • Shumak, K. H., Batchelor, J. R., and Watts, H. G. 125I-labelled rat transplantation alloantibodies. Transplantation 15:70–79, 1973.

    PubMed  CAS  Google Scholar 

  • Silvers, W. K., and Billingham, R. E. Influence of the Ag-B locus on reactivity to skin homografts and tolerance responsiveness in rats. Transplantation 8:167–178, 1969.

    PubMed  CAS  Google Scholar 

  • Silvers, W. K., and Billingham, R. E. Contributions of the rat to the immunobiology of tissue transplantation. Transplant. Proc. 2:152–161, 1970.

    PubMed  CAS  Google Scholar 

  • Silvers, W. K., Wilson, D. B., and Palm, J. Mixed leukocyte reactions and histocompatibility in rats. Science 155:703–704, 1967.

    PubMed  CAS  Google Scholar 

  • Simonsen, M. On the measurement of antigenic strength. Transplant. Rev. 3:22–35, 1970.

    Google Scholar 

  • Simpson, G. G. The nature and origin of supraspecific taxa. Cold Spring Harbor Symp. Quant. Biol. 24:255–271, 1959.

    PubMed  CAS  Google Scholar 

  • Snell, G. D. The H-2 locus of the mouse: Observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol. (Praha) 14:335–358, 1968.

    CAS  Google Scholar 

  • Sørensen, S. F. Evidence for gene dose effect of H-1 (Ag-B) determined antigens in rat mixed lymphocyte culture. Acta Pathol. Microbiol. Scand. (Section B) 79:483–488, 1971.

    Google Scholar 

  • Sørensen, S. F., Bildsøe, P., and Simonsen, M. Effect of strong and weak histocompatibility antigens on the mixed lymphocyte culture reaction in rats. Acta Pathol Microbiol. Scand. (Section B) 79:475–482, 1971.

    Google Scholar 

  • Soulillou, J.-P., Carpenter, C. B., D’Apice, A. J. F., and Strom, T. B. The role of nonclassical, Fc receptor-associated, Ag-B antigens (Ia) in the allograft enhancement. J. Exp. Med. 143:405–421, 1976.

    PubMed  CAS  Google Scholar 

  • Staines, N. K., Guy, K., and Davies, D. A. L. Passive enhancement of mouse skin allografts: Specificity of the antiserum for major histocompatibility complex antigens. Transplantation 18:192–195, 1974.

    PubMed  CAS  Google Scholar 

  • Stankus, R. P., and Leslie, G. A. Cross-idiotypic specificity of rat antibodies to group A streptococcal carbohydrate. J. Immunol 113:1859–1863, 1974.

    PubMed  CAS  Google Scholar 

  • Stankus, R. P., and Leslie, G. A. Genetic influences on the immune response of rats to streptococcal A carbohydrate. Immunogenetics 2:29–38, 1975.

    Google Scholar 

  • Stankus, R. P., and Leslie, G. A. Rat interstrain antibody response and cross-idiotypic specificity. Immunogenetics 3:65–73, 1976.

    Google Scholar 

  • Štark, O., Frenzl, B., and Křen, V. Erythrocyte and transplantation antigens in inbred strains of rats. VII. H-1 alleles of the LEP, CAP, BN, BD V, BD VII and BD X strains. Folia Biol (Praha) 14:169–175, 1968a.

    Google Scholar 

  • Štark, O., Günther, E., Kohoutová, M., and Vojčík, V. Genetic recombination in the major histocompatibility complex (H-1, Ag-B) of the rat. Immunogenetics-in press, 1977.

    Google Scholar 

  • Štark, O., and Hauptfeld, M. Serologically detected Rt H-1 antigens of the AS2, VM and Y59 rats. Folia Biol (Praha) 15:35–40, 1969.

    Google Scholar 

  • Štark, O., and Křen, V. Erythrocyte and transplantation antigensin inbred strains of rats. II. Antigens of the AVN strain. Folia Biol. (Praha) 13:93–99, 1967a.

    Google Scholar 

  • Štark, O., and Křen, V. Erythrocyte and transplantation antigens in inbred strains of rats. III. Antigens of the BP strain. Folia Biol. (Praha) 13:299–305, 1967b.

    Google Scholar 

  • Štark, O., and Křen, V. Erythrocyte and transplantation antigens in inbred strains of rats. IV. Antigens of the WP strain. Folia Biol. (Praha) 13:306–311, 1967c.

    Google Scholar 

  • Štark, O., and Křen, V. Erythrocyte and transplantation antigens in inbred strains of rats. V. Antigens of the Lewis strain. Folia Biol. (Praha) 13:312–316, 1967d.

    Google Scholar 

  • Štark, O., and Křen, V. Erythrocyte and transplantation antigens in inbred strains of rats. VI. The histocompatibility-1 system and its alleles. Folia Biol (Praha) 13:356–360, 1967e.

    Google Scholar 

  • Štark, O., and Křen, V. Five congenic resistant lines of rats differing at the rat H-1 locus. Transplantation 8:200–203, 1969.

    PubMed  Google Scholar 

  • Štark, O., Křen, V., and Frenzl, B. Histocompatibility locus of the rat. Tenth International Conference on Animal Blood Groups and Biochemical Polymorphismes, Paris 1966, In Poly-morphismes Biochemiques des Animaux-pp. 501–506, ed. Institut Nationale de la Recherche Agronomique, Paris, 1967a.

    Google Scholar 

  • Štark, O., Křen, V., and Frenzl, B. Erythrocyte and transplantation antigens in inbred strains of rats: I. Serological analysis of strain-specific antigens. Folia Biol. (Praha) 13:85–92, 1967b.

    Google Scholar 

  • Štark, O., Křen, V., Frenzl, B., and Křenová, D. Histocompatibility-1 alleles in inbred rats of the BD II, WR, AGA, CDF, AS, BS, HS and DA strains. Folia Biol. (Praha) 14:425–432, 1968b.

    Google Scholar 

  • Štark, O., Křen, V., Frenzl, B., and Kršiaková, M. Independent segregation of the Rt H-1 alleles and coat color genes in the rat. Folia Biol. (Praha) 15:410–473, 1969b.

    Google Scholar 

  • Štark, O., Křen, V., Křenová, D., and Frenzl, B. Serologically detected antigens in two sublines of the WAG rats. Folia Biol (Praha) 15:259–262, 1969a.

    Google Scholar 

  • Štark, O., Křen, V., and Günther, E. Rt H-1 antigens in 39 rat strains and six congenic lines. Transplant. Proc. 3:165–168, 1971.

    PubMed  Google Scholar 

  • Štark, O., Křenová, D., Křen, V., and Frenzl, B. Immunological relationship between five congenic lines of rats and their parental strains. Folia Biol. (Praha) 16:1–11, 1970.

    Google Scholar 

  • Štark, O., and Zeiss, I. Antigene des ersten Histokompatibilitätssystems (H-l) bei den BD-(Berlin-Druckrey) und BDE-Ratteninzuchtstämmen. Z. Versuchstierkd. 12:27–40, 1970.

    PubMed  Google Scholar 

  • Stenglein, B., Thoenes, G. H., and Günther, E. Genetically controlled autologous immune complex glomerulonephritis in rats. J. Immunol. 115:895–897, 1975.

    PubMed  CAS  Google Scholar 

  • Stroehmann, I., and DeWitt, C. W. Rat transplantation antigens. I. Extraction and partial purification of soluble antigen. Immunology 23:921–928, 1972a.

    PubMed  CAS  Google Scholar 

  • Stroehmann, I., and DeWitt, C. W. Rat transplantation antigens. II. Solubilization of multiple antigenic specificities. Immunology 23:929–935, 1972b.

    PubMed  CAS  Google Scholar 

  • Strom, T. B., Carpenter, C. B., Phillips, S. M., Garovoy, M. R., and Merril, J. P. Rejection and enhancement in an in vitro model of alloimmunity. Comparison of F1 and parental strains. Transplantation 16:103–109, 1973.

    PubMed  CAS  Google Scholar 

  • Stuart, F. P., McKearn, T. J., and Fitch, F. W. Immunological enhancement of renal allografts. Transplant. Proc. (Suppl. 1) 6:53–57, 1974.

    PubMed  CAS  Google Scholar 

  • Stuart, F. P., Saitoh, T., and Fitch, F. W. Rejection of renal allografts: Specific immunologic suppression. Science 160:1463–1465, 1968.

    PubMed  CAS  Google Scholar 

  • Svejgaard, A., Platz, P., Ryder, L. P., Staub-Nielsen, L., and Thomsen, M. HL-A and disease associations—a Survey. Transplant. Rev. 22:3–43 1975.

    PubMed  CAS  Google Scholar 

  • Tada, N., Itakura, K., and Aizawa, M. Genetic control of the antibody response in inbred rats. J. Immunogenetics 1:265–275, 1974.

    CAS  Google Scholar 

  • Tada, N., Itakura, K., and Aizawa, M. Immune response gene (Ir-SRBC) exerts its effect via macrophages in inbred rats. J. Immunogenetics 3:49–60, 1976.

    CAS  Google Scholar 

  • Taylor, H. R., and Morris, P. J. A simple micromethod for detecting isohaemagglutinins in rats using papainized red blood cells. Aust. J. Exp. Biol. Med. Sci. 48:245–247, 1970.

    PubMed  CAS  Google Scholar 

  • Thoenes, G. H. Induction of unresponsiveness to organ transplants in congenic strains of rats and other mammals. In W. H. Hildemann, and A. A. Benedict (eds.), Immunologic Phylogeny,pp. 457–466, Plenum Publishing Corp., New York, 1975.

    Google Scholar 

  • Thoenes, G. H., Urban, G., and Doering, I. Kidney transplantation between congenic versus standard inbred strains of rats. I. The significance of H-l and non-H-1 gene differences. Immunogenetics 3:239–253, 1974.

    Google Scholar 

  • Thoenes, G. H., and White, E. Enhancement-induced specific nonreactivity in experimental kidney transplantation. Transplantation 15:308–311, 1973.

    PubMed  CAS  Google Scholar 

  • Thoenes, G. H., White, E., and Hildemann, W. H. Alloantibodies induced by weaker histocompatibility antigens in rats. J. Immunol. 104:1447–1452, 1970.

    PubMed  CAS  Google Scholar 

  • Tilney, N. L., and Bell, P. R. F. Studies on enhancement of cardiac and renal allografts in the rat. Transplantation 18:31–37, 1974.

    PubMed  CAS  Google Scholar 

  • Tinbergen, W. J. The effects of some immunosuppressive agents on kidney graft survival in rats. Transplantation 6:203–207, 1968.

    PubMed  CAS  Google Scholar 

  • Virolainen, M., Häyry, P., and Defendi, V. Effect of presensitization on the mixed lymphocyte reaction of rat spleen cell cultures. Transplantation 8:179–188, 1969.

    PubMed  CAS  Google Scholar 

  • Vladutiu, A. O., and Rose, N. R. Autoimmune murine thyroiditis. Relation to histocompatibility (H-2) type. Science 174:1137–1139, 1971.

    PubMed  CAS  Google Scholar 

  • White, E., Hildemann, W. H., and Mullen, Y. Chronic kidney allograft reactions in rats. Transplantation 8:602–617, 1969.

    PubMed  CAS  Google Scholar 

  • Williams, R. M., and Moore, M. J. Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in rats. J. Exp. Med. 138:775–783, 1973.

    PubMed  CAS  Google Scholar 

  • Williams, M., and Moore, M. J. Genetic recombination between serologically defined antigens and mixed lymphocyte reactivity in the rat major histocompatibility complex. In M. Stephenson and A. Brzytwa (eds.), Transplantation Abstracts-Sixth International Congress of the Transplantation Society 1976, pp. 66–67, Grune and Stratton, New York, 1976.

    Google Scholar 

  • Williams, R. M., Moore, M. J., and Benacerraf, B. Genetic control of thymus-derived cell function. IV. Mitogen responsiveness and mixed lymphocyte reactivity of thymus cells and lymph node cells from Lewis and Brown Norway rats. J. Immunol 111:1571–1578, 1973.

    PubMed  CAS  Google Scholar 

  • Wilson, D. B. Quantitative studies on the mixed lymphocyte interaction in rats. I. Conditions and parameters of response. J. Exp. Med. 126:625–654, 1967.

    PubMed  CAS  Google Scholar 

  • Wilson, D. B. Immunologic reactivity to major histocompatibility alloantigens: HARC, effector cells and the problem of memory. Prog. Immunol. II, 2:145–156, 1974.

    Google Scholar 

  • Wilson, D. B., Blyth, J. L., and Nowell, P. C. Quantitative studies on the mixed lymphocyte interaction in rats. III. Kinetics of the response. J. Exp. Med. 128:1157–1181, 1968.

    PubMed  CAS  Google Scholar 

  • Wilson, D. B., Howard, J. C., and Nowell, P. C. Some biological aspects of lymphocytes reactive to strong histocompatibility alloantigens. Transplant. Rev. 12:3–29, 1972.

    PubMed  CAS  Google Scholar 

  • Wilson, D. B., and Nowell, P. C. Quantitative studies on the mixed lymphocyte interaction in rats. V. Tempo and specificity of the proliferative response and the number of reactive cells from immunized donors. J. Exp. Med. 133:442–453, 1971.

    PubMed  CAS  Google Scholar 

  • Wilson, D. B., Silvers, W. K., and Nowell, P. C. Quantitative studies on the mixed lymphocyte interaction in rats. II. Relationship of the proliferative response to the immunologic status of the donors. J. Exp. Med. 126:655–665, 1967.

    PubMed  CAS  Google Scholar 

  • Wonigeit, K., and Stumpenhorst, R. Serologische Charakterisierung von zwei Alloantigensystemen auf Thymus und thymusabhängigen Lymphozyten der Ratte (Abstract). Z. Immunitaeis-forsch. 150:257–258, 1975.

    Google Scholar 

  • Würzburg, U. Correlation between the immune response to an enzyme and histocompatibility type in rats. Eur. J. Immunol. 1:496–497, 1971.

    Google Scholar 

  • Würzburg, U., Schütt-Gerowitt, H., and Rajewsky, K. Characterization of an immune response gene in rats. Eur. J. Immunol. 3:762–766, 1973.

    PubMed  Google Scholar 

  • Zeiss, I. Antigenic interrelationship and number of independently segregating histocompatibility loci in three isohistogenic strains of rats. Transplantation 5:1393–1399, 1967.

    Google Scholar 

  • Zeiss, I. M., Nisbet, N. W., and Heslop, B. F. A male antigen in rats. Transplant. Bull. 30:161, 1962.

    Google Scholar 

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  1. E. Günther
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  1. The Wistar Institute for Anatomy and Biology, 36 Street at Spruce, Philadelphia, Pa., 19104, USA

    Dietrich Götze

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Günther, E., Štark, O. (1977). The Major Histocompatibility System of the Rat (Ag-B or H-1 System). In: Götze, D. (eds) The Major Histocompatibility System in Man and Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95293-7_7

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