The Major Histocompatibility System of the Dog

  • H. M. Vriesendorp
  • H. Grosse-Wilde
  • M. E. Dorf

Abstract

Dogs are frequently used as experimental animals in transplantation research. For ethical and economical reasons this use should be limited to those experimental protocols in which members of the canine species will provide the best answers to the questions that an investigator wants to answer. This will be the case when transplantation surgeons require an experimental subject of a size and temperament that allows major operations and intensive postoperative care. Dogs may also be useful when new biological concepts, after their development in inbred murine strains, need further definition and clarification in an outbred preclinical animal model. In such an animal model histocompatibility systems should be amenable for analysis for a proper evaluation of the results obtained and an extrapolation to the treatment of human patients. Because of this and because of other advantageous properties of dogs, such as large family size and relatively short gestation and generation times (63 and 360 days, respectively), histocompatibility has been studied in this species.

Keywords

Acetone Recombination Hepes Sine Thymidine 

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© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • H. M. Vriesendorp
  • H. Grosse-Wilde
  • M. E. Dorf

There are no affiliations available

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