Abstract
The knowledge about the major histocompatibility system (MHS) in man has evolved in very close interrelationship with the pioneer work in the mouse model with an intensive exchange of methodology and “ideology” concerning the analysis of serologic data. As will be documented in this book there is a remarkable analogy between the histocompatibility systems of many mammalian species, most notably of mouse and man. This is expressed in a phrase coined by Jean Dausset: “The mouse has never lied” relating to the fact that most of the systems found in the mouse H-2 complex (the MHS of the mouse) have also been described for man and other species. These analogies are in marked contrast to the widely different experimental approaches used for histocompatibility research in both species. Through the pioneer work of Gorer and Snell (Gorer 1938, 1961; Snell 1948, 1953) it has become possible to use inbred strains of mice, which allows the detailed genetic characterization of a relatively restricted number of H-2 haplotypes (i.e., chromosomes carrying the H-2 region) using a limited number of recombinants. In man one is faced with an outbred population containing an almost unlimited number of “different haplotypes representing a very large number of recombinations. Therefore the laws of population genetics have to be utilized in the analysis of serologic data in an outbred species. As history has shown, both types of basic approaches have provided contributions that were essential for reaching today’s state of knowledge about the major histocompatibility complex in both species.
This work was partially supported by NIH grant CA-10097 and DFG grant SFB-37-B6 and by SFB-37-B1, B2 as well as by grant A1-92/9/10 of Deutsche Forschungsgemeinschaft.
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Albert, E., Götze, D. (1977). The Major Histocompatibility System in Man. In: Götze, D. (eds) The Major Histocompatibility System in Man and Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95293-7_2
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