Abstract
Adriamycin is a new antitumor antibiotic isolated from cultures of Streptomyces peucetius par. caesius [1]. The structural formula of adriamycin differs from daunomycin only in the substitution of a hydroxyl group for a hydrogen atom in the acetyl radical of the aglycone moiety of daunomycin [2]. Adriamycin was reported to possess a higher therapeutic index than daunomycin in serval experimental tumor systems [3, 4]. This paper deals with cross-resistance studies using various resistant sublines of Yoshida sarcoma in rats and L1210 leukemia in mice. Combination chemotherapy of adriamycin with various antitumor agents were also studied in L1210 leukemia.
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Hoshino, A., Kato, T., Amo, H., Ota, K. (1972). Antitumor Effects of Adriamycin on Yoshida Rat Sarcoma and L 1210 Mouse Leukemia — Cross-resistance and Combination Chemotherapy. In: Carter, S.K., Marco, A.D., Ghione, M., Krakoff, I.H., Mathé, G. (eds) International Symposium on Adriamycin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95227-2_9
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DOI: https://doi.org/10.1007/978-3-642-95227-2_9
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