Adriamycin, Vincristine and Prednisone in the Treatment of Malignant Tumors Resistant to Conventional Chemotherapy
Adriamycin (14-hydroxy-daunorubicine), a new cytotoxic antibiotic isolated from cultures of streptomyces peuceticus var. caesius, was introduced to clinical chemotherapy of human neoplasms in 1969 by Bonadonna and co-workers . The drug seems to have significant antitumor activity in a much larger spectrum of malignant diseases than daunorubicine, especially in solid tumors [1-3]. It has mainly been used as a single agent. It was the aim of this study to explore antitumor effect and toxicity of the combination chemotherapy with adriamycin, vincristine and prednisone.
KeywordsToxicity Depression Leukemia Sarcoma Cyclophosphamide
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