Clinical Trials with Adriamycin. Results of Three-Years Study

  • Gianni Bonadonna
  • Silvio Monfardini
  • Mario De Lena
  • Franca Fossati-Bellani
  • Gianni Beretta

Abstract

The results of the initial clinical studies (Phase I and preliminary Phase II evaluation) carried out at the National Cancer Institute of Milan an adriamycin, a 14- hydroxy analogue of daunomycin [1,17], have been reported since 1969 in numerous papers and meetings [2–7, 9–12, 24–26]. Since favorable therapeutic results appeared evident from the first series of patients, the trials have been actively pursued and the drug was tested on a large population of patients with different forms of neoplastic disease.

Keywords

Toxicity Lymphoma Methotrexate Prednisone Prednisolone 

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1972

Authors and Affiliations

  • Gianni Bonadonna
    • 1
  • Silvio Monfardini
    • 1
  • Mario De Lena
    • 1
  • Franca Fossati-Bellani
    • 1
  • Gianni Beretta
    • 1
  1. 1.Istituto Nationale per lo Studio e la Cura dei TumoriMilanoItaly

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