Summary
Oestrogens are excreted to a large extent as glucuronides. The enzyme UDP-glucuronyltransferase (EC 2.4.1.17) is present in several organs of the mammal in addition to the liver. The enzyme is located primarily in the microsomal fraction. Human liver microsomes conjugate the 16α-hydroxyl group of oestriol. The oestriol 16α-glucuronyltransferase of the microsomes can be “solubilised” by treatment with deoxycholate; from a study of molecular weight and phospholipid content, the enzyme appears to be a lipoprotein complex of the microsomal membrane.
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© 1971 Springer-Verlag
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Rao, G.S. (1971). Steroidglucuronyltransferasen. In: Kracht, J. (eds) Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes. Symposion der Deutschen Gesellschaft für Endokrinologie in Hamburg vom 4.–6. März 1971, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95216-6_2
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DOI: https://doi.org/10.1007/978-3-642-95216-6_2
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