Skip to main content
SpringerLink
Log in

Recent Developments in the Study of Hormone Effects and Metabolism in Prostate Tissue

  • Chapter
Book cover Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes

  • 22 Accesses

Abstract

I should like to express my thanks to the German Endocrine Society for the invitation to participate in this Symposium and my appreciation of the timely choice of topics for this morning’s discussion. Recent developments in the study of hormone effects and metabolism in prostate tissue hold the promise of bridging the large gap in biochemical knowledge between the developmental, histologic and clinical contributions of Lacassagne (1933 a, b), Huggins (1941, 1948), Moore (1947, 1952), Price (1957, 1963) and Woodruff (1960, 1962) and current concepts of the molecular mode of hormone action so admirably stated by Karlson (1963).

Supported by United States Public Health Service Grant CA-10343 from the National Cancer Institute and by appropriations of the Commonwealth of Massachusetts, Item 2026-50-02.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aaronson, S.A., Nator, Y., Tarver, H.: Proc. Soc. exp. Biol. (N.Y.) 120, 9 (1965).

    CAS  Google Scholar 

  • Ahmed, K., Williams-Ashman, H.G.: Biochem. J. 113, 829 (1969).

    PubMed  CAS  Google Scholar 

  • Bashirelahi, N., Villee, C.A.: Biochim. biophys. Acta (Amst.) 202, 192 (1970).

    CAS  Google Scholar 

  • Baulieu, E.E., Jung, I.: Biochem. biophys. Res. Commun. 38, 599 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Baulieu, E.E., Lasnitzki, I., Robel, P.: In: “Advances in the Biosciences 3”, p. 169 (G. Raspé, ed.) New York: Pergamon Press, Braunschweig, Berlin: Vieweg, 1968.

    Google Scholar 

  • Baulieu, E.E., Mauvais-Jarvis, P.: J. biol. Chem. 239, 1569 (1964).

    PubMed  CAS  Google Scholar 

  • Bruchovsky, N., Wilson, J.D.: J. biol. Chem. 243, 5953 (1968 a).

    PubMed  CAS  Google Scholar 

  • Bruchovsky, N., Wilson, J.D.: J. biol. Chem. 243, 2012 (1968 b).

    PubMed  CAS  Google Scholar 

  • Bushs I.E.: In: “The Chromatography of Steroids”, p. xviii. New York: Pergamon Press, 1961.

    Google Scholar 

  • Butenandt, A., Gunther, H., Turba, F.: Z. physiol. Chem. 322, 28 (1960).

    Article  CAS  Google Scholar 

  • Chamberlain, J., Jagarinec, N., Ofner, P.: Biochem. J. 99, 610 (1966).

    PubMed  CAS  Google Scholar 

  • Coffey, D.S, Ichinose, R.R., Shimazaki, J., Williams-Ashman, H.G.: Molec. Pharmacol. 4, 580 (1968).

    CAS  Google Scholar 

  • Fang, S., Anderson, K.M., Liao, Sh.: J. biol. Chem. 244, 6584 (1969).

    PubMed  CAS  Google Scholar 

  • Fang, S., Liao, Sh.: Molec. Pharmacol. 5, 428 (1969).

    CAS  Google Scholar 

  • Fang, S., Liao, Sh.: J. biol. Chem. 246, 16 (1971).

    PubMed  CAS  Google Scholar 

  • Farnsworth, W.E.: Biol. Reprod. 3, 218 (1970).

    PubMed  CAS  Google Scholar 

  • Fraley, E.E., Ecker, S., Vincent, M.M.: Science 170, 540 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Franks, L.M., O’Shea, J.D., Thomson, A.E.R.: Cancer (Philad.) 17, 983 (1964).

    Article  CAS  Google Scholar 

  • Franks, L.M., Riddle, P.N., Carbonell, A.W., Gey, G.O.: J. Path. Bact. 100, 113 (1970).

    Article  CAS  Google Scholar 

  • Gloyna, R.E., Siiteri, P.K., Wilson, J.D.: J. clin. Invest. 49, 1746 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Hilgar, A.G., Hummel, D.J.: “Androgenic and Myogenic Endocrine Bioassay Data”, Issue 1, pp. 1–243. Cancer Chemotherapy Nat. Serv. Center, Nat. Inst. Health, Bethesda, Md., 1964.

    Google Scholar 

  • Huggins, C., Hodges, C.V.: Cancer Res. 1, 293 (1941).

    CAS  Google Scholar 

  • Huggins, C., Webster, W.O.: J. Urol. (Baltimore) 59, 258 (1948).

    CAS  Google Scholar 

  • Jensen, E.V.: In: “Some Aspects of Aetiology and Biochemistry of Prostate Cancer” (K. Griffiths and C.G. Pierrepoint, eds.), Third Tenovus Workshop, Cardiff, Wales, 1970, p. 151.

    Google Scholar 

  • Jensen, E.V., Suzuki, T., Kawashima, T., Stumpf, W.E., Jungblut, P.W., DeSombre, E.R.: Proc. nat. Acad. Sci. (Wash.) 59, 632 (1968).

    Article  CAS  Google Scholar 

  • Karlson, P.: Perspect. Biol. Med. 6, 203 (1963).

    PubMed  CAS  Google Scholar 

  • Lacassagne, A.: C. R. Soc. Biol. (Paris) 113, 590 (1933 a).

    CAS  Google Scholar 

  • Lacassagne, A., Villela, E.: C. R. Soc. Biol. (Paris) 114, 870 (1933 b).

    Google Scholar 

  • Leav, I., Ling, G.V.: Cancer (Philad.) 22, 1329 (1968)

    Article  CAS  Google Scholar 

  • Leav, I., Morfin, R.F., Ofner, P., Cavazos, L.F., Leeds, E.B.: Endocrinology 89, 465 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Liao, Sh., Barton, R.W., Lin, A.H.: Proc. nat. Acad. Sci. (Wash.) 55, 1593 (1966 a).

    Article  CAS  Google Scholar 

  • Liao, Sh., Fang, S.: Vitam. and Horm. 27, 17 (1969).

    Article  CAS  Google Scholar 

  • Liao, Sh., Lin, A.H.: Proc. nat. Acad. Sci. (Wash.) 57, 379 (1967).

    Article  CAS  Google Scholar 

  • Liao, Sh., Lin, A.H., Barton, R.W.: J. biol. Chem. 241, 3869 (1966 b).

    PubMed  CAS  Google Scholar 

  • Liao, Sh., Lin, A.H., Tymoczko, J.L.: Biochim. biophys. Acta. (Amst.) (1971, in press).

    Google Scholar 

  • Liao, Sh., Stumpf, W.E.: Endocrinology 83, 629 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Liao, Sh., Mainwaring, W.I.P.: J. Endocr. 45, 531 (1969).

    Article  Google Scholar 

  • Liao, Sh.: Biochem. biophys. Res. Commun. 40, 192 (1970).

    Article  Google Scholar 

  • Martelo, O.J., Woo, S.L.C., Reimann, E.M., Davie, E.W.: Biochemistry (Wash.) 9, 4807 (1970).

    Article  CAS  Google Scholar 

  • Mauvais-Jarvis, P., Bercovici, J.-P., Crépy, O., Gauthier, F.: J. clin. Invest. 49, 31 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Mauvais-Jarvis, P., Floch, H.H., Bercovici, J.-P.: J. clin. Endocr. 28, 460 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Moore, R.A.: In: “Endocrinology of Neoplastic Diseases” (G.H. Twombly and G.T. Pack, eds.) Chapter 8. London and New York: Oxford Univ. Press, 1947.

    Google Scholar 

  • Moore, R.A.: In: “Cowdry’s Problems of Ageing” (A.I. Lansing, ed.), 3rd ed. Baltimore, Md.: Williams and Wilkins, 1952.

    Google Scholar 

  • Morfin, R.F.: “Métabolisme des Androgènes au Niveau des Prostates Humaines et Canines”. Thesis for the Doctorat d’Etat of the Faculty of Sciences of the University of Paris (1970).

    Google Scholar 

  • Morfin, R.F., Aliapoulios, M.A., Bennett, A.H., Harrison, J.H., Ofner, P.: Proc. 3rd Intern. Congr. Hormonal Steroids, Hamburg, 1970, Excerpta med. Intern. Congr. Ser. Excerpta Med. Found., Amsterdam (in press 1971).

    Google Scholar 

  • Morfin, R.F., Aliapoulios, M.A., Chamberlain, J., Ofner, P.: Endocrinology 87, 394 (1970). McDonald, P., Beyer, C., Newton, F., Brien, B., Baker, R., Tan, H.S., Sampson, C., Kitching, P., Greenhill, R., Pritchard, D.: Nature 227, 964 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Neumann, F., Berswordt-Wallrabe, R. von: J. Endocr. 35, 363 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Ofner, P.: Vitam. and Horm. 26, 237 (1968).

    Article  CAS  Google Scholar 

  • Ofner, P., Morfin, R.E., Vena, R.L., Aliapoulios, M.A.: In: “Some Aspects of Aetiology and Biochemistry of Prostate Cancer” (K. Griffiths and C.G. Pierrepoint, eds.) Third Tenovus Workshop, Cardiff, Wales, 1970, p. 551.

    Google Scholar 

  • Price, D.: In: “The Biology of the Prostate and Related Tissues” (E.P. Vollmer and G. Kauffmann, eds.), Nat. Cancer Inst. Monograph 12 (1963).

    Google Scholar 

  • Price, D., Ingle, D.J.: Rev. suisse Zool. 64, 743 (1957). Ritter, C.: Molec. Pharmacol. 2, 125 (1966).

    Google Scholar 

  • Rosenfeld, M.G., O’Malley, B.W.: Science 168, 253 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Ryan, K.J.: J. biol. Chem. 234, 268 (1959).

    PubMed  CAS  Google Scholar 

  • Shimazaki, J. Matsushita, I., Furuya, N., Yamanaka, H., Shida, K.: Endocr. jap. 16, 453 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Siiteri, P.K., Tippit, P., Yates, C., jr., Porter, J.C.: Endocrinology 82, 837 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Siiteri, P.K., Wilson, J.D.: J. clin. Invest. 49, 1737 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Singhal, R.L.: Personal Communication (1971).

    Google Scholar 

  • Singhal, R.L., Vijayvargiya, R., Ling, G.M.: Science 168, 261 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Stern, J.M., Eisenfeld, A.J.: Science 166, 233 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Tveter, K.J.: Acta Endocr. (Kbh.) 63, 489 (1970).

    CAS  Google Scholar 

  • Tveter, K.J., Attramadal, A.: Endocrinology 85, 350 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Unhjem, O.: Acta Endocr. (Kbh.) 65, 525 (1970).

    CAS  Google Scholar 

  • Unhjem, O., Tveter, K.J., Aakvaag, A.: Acta Endocr. (Kbh.) 62, 153 (1969).

    CAS  Google Scholar 

  • Valensin, G.: In: “La prostate”, p. 38. La Jeune Parque, Utrecht: Bosch, 1965.

    Google Scholar 

  • Villee, C.A., Fujii, T.: In: “Testosterone”. (J. Tamm, ed.). Proc. Workshop Conf. Tremsbüttel, Germany, 1967, p. 96. Stuttgart: Thieme, 1968.

    Google Scholar 

  • Villee, C.A., Fujii, T., Proc. nat. Acad. Sci. (Wash.) 62, 836 (1969).

    Article  Google Scholar 

  • Voigt, K.D.: In: “Testosterone” (J. Tamm, ed.). Proc. Workshop Conf. Tremsbüttel, Germany, 1967, p. 101. Stuttgart: Thieme, 1968.

    Google Scholar 

  • Walsh, P.C., Korenman, S.G.: J. Urol. 105, 850 (1971).

    PubMed  CAS  Google Scholar 

  • Watson, J.D.: In: “Molecular Biology of the Gene”, 2nd ed. p. 372. New York: Benjamin, Inc., 1970.

    Google Scholar 

  • Williams-Ashman, H.G.: In: “The Androgens of the Testis”, (K.B. Eik-Nes, eds.), p. 117. New York: Marcel Dekker, Inc., 1970.

    Google Scholar 

  • Williams-Ashman, H.G., Liao, Sh., Hancock, R.L., Jurkowitz, L., Silverman, D.A.: Recent Progr. Hormone Res. 20, 247 (1964).

    PubMed  CAS  Google Scholar 

  • Wilson, J.D., Bruchovsky, N., Chatfield, J.N.: Proc. 3rd Intern. Congr. Ser. No. 184, p. 17. Excerpta Med. Found., Amsterdam (1969).

    Google Scholar 

  • Woodruff, M.W., Perez-Mesa, C.: J. Urol. 88, 273 (1962).

    PubMed  CAS  Google Scholar 

  • Woodruff, M.W., Umiker, W.O.: J. Urol. 84, 162 (1960).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Steroid Biochemistry Laboratory of the Medical Services, Lemuel Shattuck Hospital, Boston, Massachusetts, USA

    P. Ofner

  2. Department of Public Health, Commonwealth of Massachusetts, Boston, Massachusetts, USA

    P. Ofner

  3. Departments of Pharmacology, Harvard School of Dental Medicine and Harvard Medical School, Boston, Massachusetts, USA

    P. Ofner

  4. Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA

    P. Ofner

Authors
  1. P. Ofner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Gießen, Deutschland

    Joachim Kracht

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer-Verlag

About this chapter

Cite this chapter

Ofner, P. (1971). Recent Developments in the Study of Hormone Effects and Metabolism in Prostate Tissue. In: Kracht, J. (eds) Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes. Symposion der Deutschen Gesellschaft für Endokrinologie in Hamburg vom 4.–6. März 1971, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95216-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95216-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95217-3

  • Online ISBN: 978-3-642-95216-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation