Summary
A survey is given of recent developments in the field of the therapeutical application of progestagens. Introductory remarks deal with the chemical structure, the profile of actions and the non-endocrine side effects of progestational agents. It is emphasized that the systemic actions of progestagens on skin, connective tissue, skeleton, blood clotting, vascular system, psyche etc. are poorly understood at present and need further elucidation.
With regard to the clinical application of progestagens, some new indications outside the gynecological and obstetrical speciality, i.e. hormone-dependent tumours, pubertas praecox, migraine and dermatosclerosis, are reported.
Recent progress in hormonal contraception with progestagens alone is the main topic of the review. For introductory information, some basic aspects concerning the influence of progestational agents on the endocrinology of the menstrual cycle in dependence on timing and dosage of the application are discussed. Special attention is paid to the contraceptive action of continuous low doses of progestagens both from the theoretical and clinical point of view. Some recent advances in the field of contraception such as long-acting injections of depot-preparations, subdermal implants of progestagen-containing silastic capsules, intrauterine, intracervical and intra-vaginal devices with progestagen fillings and the postcoital intake of progestational agents in low doses are also mentioned.
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Literatur
Achari, K., Prasad, V.: Bihar Obstet, u. Gynaec. Soc., 2nd Ann. Conf. Patna Oct. 1969.
Apostolakis, M., Becker, H., Voigt, K.D.: Steroids l7, 146 (1966).
Benagniano, G., Ermini, M., Chang, C.C., Sundaram, K., Kincl, F.A.: Acta endocr. (Kbh.) 63, 29 (1970).
Benjamin, F., Casper, D.J.: Amer. J. Obstet. Gynec. 94, 991 (1966).
Berndt, G., Stender, H. St.: Dtsch. Med. Wschr. 95, 2399 (1970).
Bradley, W.G., Hudgson, P., Foster, J.B., Newell, D.J.: Brit. Med. J.1968 III, 531.
Breuer, H.: Lancet 1970 II, 615.
Camanni, F., Massara, F., Molinatti, G.M.: Acta endocr. (Kbh.) 43, 477 (1963).
Clinch, J., Tindall, V.R.: Brit. Med. J. 1969 I, 602.
Cohen, M.R., Pandya, G.N., Scommegna, A.: Fertil. and Steril. 21, 715 (1970).
Collip, P.J., Kaplan, S.A., Boyle, D.C., Plachte, F., Kogut, M.D.: Amer. J. Dis. Child. 108, 399 (1964).
Coutinho, E.M., Mattos, C.E.T., Sant’Anna, A.R., Filho, I.A., Silva, M.C., Tatum, H.J.: Contracept. 2, 313 (1970).
Croxatto, H., Diaz, S., Vera, R., Etchart, M., Atria, P.: Amer. J. Obstet. Gynec. 105, 1135 (1969).
Dapunt, O.: Bull. Schweiz. Akad. med. Wiss. 25, 481 (1970).
Diczfalusy, E., Goebelsmann, U., Johannisson, E., Tillinger, K.G., Wide, L.: Acta endocr. (Kbh.) 62, 679 (1969).
Dziuk, P.J., Cook, B.: Endocrinology 78, 208 (1966).
Eisalo, A., Heino, A., Räsänen, V.: Acta obstet, gynec. scand. 47, 58 (1968).
Fotherby, K., Svendsen, K.E., Foss, G.L.: J. Reprod. Fertil. Suppl. 5, 155 (1968).
Gardner, J.M., Mishell, D.R.: Fertil. and Steril. 21, 286 (1970).
Geller, J., Fruchtman, B., Meyer, C., Newman, H.: J. clin. Endoer. 27, 556 (1967).
Geller, S., Scholler, R.: Path. et Biol. 19, 157 (1971).
Gilfrich, H.J., Nieschlag, E., Duceck, J., Overzier, C.: Dtsch. Med. Wschr. 94, 2473 (1969).
Goldzieher, J.W., Kleber, J.W., Moses, L.E., Rathmacher, R.P.: Contracept. 2, 225 (1970).
Grant, E., Pryse-Davies, J.: Brit. Med. J. 1968 III, 777. Greenblatt, R.B.: Med. Sci. 37 (1967).
Gutièrrez-Najar, A., Márquez-Monter, H., Cortéz-Gallegos, V., Giner-Velázquez, J., Martinez-Manautou, J.: Amer. J. Obstet. Gynec. 102, 1018 (1968).
Hammerstein, J.: Arch. Gynäk. 207, 48 (1969 a).
Hammerstein, J.: 15. Symp. Dtsch. Ges. Endokrin. 15, 57, 1969 b.
Hammerstein, J.: Symp. der Beratergruppe für Arzneimittelsicherheit beim Bundesminister für Jugend, Familie und Gesundheit, Berlin, Dez. 1970 (im Druck).
Hammerstein, J., Cupceancu, B.: Dtsch. Med. Wschr. 94, 829 (1969).
Hammerstein, J., Rice, B.F., Savard, K.: J. clin. Endoer. 24, 597 (1964).
Helge, H., Weber, B., Hammerstein, J., Neumann, F.: Acta paediat. scand. 58, 672 (1969) und (unveröffentlicht) 1971.
Hoischen, W., Steigleder, G.K.: Dtsch. med. Wschr. 91, 398 (1966).
Holzmann, H., Körting, G.W., Morsches, B.: Hautarzt 16, 456 (1965).
Johansson, E.D.B.: Excerpta med. (Amst.) Intern. Congr. Ser. 210, 215 (1970).
Kaiser, R.: Symp. Dtsch. Ges. Endokrin. 6, 64 (1959).
Kaufmann, C., Zander, J.: Klin. Wschr. 34, 7 (1956).
Kenny, F.M., Midgley, A.R. jr., Jaffe, R.B., Garces, L.Y., Vasquez, A., Taylor, F.H.: J. clin. Endocr. 29, 1272 (1969).
Kesserü, E.: II. Congreso Bolivariano de Endocrinologia 1969. Symposia Litografica del Peru S.A. Lima S. 120, 1970.
Kreuzer, G., Boquoi, E.: Dtsch. med. Wschr. 95, 1863 (1970).
Kupperman, H.S., Epstein, J.A.: J. clin. Endocr. 22, 456 (1962).
Larrañaga, A., Kesserü, E.: Ginec. y Obstet. 8, 49 (1967).
Larsson-Cohn, U., Johansson, E.D.B., Gemzell, C.: Acta endocr. (Kbh.) 64, 38 (1970).
Luby, R.J.: Obstet. and Gynec. 26, 467 (1965).
Ludwig, H.: Ergebn. Angiologie 4, 81 (1970).
Lübke, F.: Arch. Gynäk. 207, 49 (1969).
Magré, J., Leroux, P., Guimbretiere, J., Cadudal: Bull. Féd. Soc. Gynéc. Obstét, franç. 21, 60 (1969).
Martinez-Manautou, J., Giner-Velasquez, J., Rudel, H.: Fertil, and Steril. 18, 57 (1967).
Mathews, J.H., Abrams, C.A.Ö., Morishima, A.: J. clin Endocr. 30, 653 (1970).
Mazaheri, A., Fotherby, K., Chapman, J.R.: J. Endocr. 47, 251 (1970).
Mears, E., Vessey, M.P., Andolśek, L., Oven, A.: Brit. Med. J. 1969 II, 730.
Mishell, D.R.: Amer. J. Obstet. Gynec. 99, 86 (1967).
Mishell, D.R., Talas, M., Parlow, A.F., Moyer, D.L.: Amer. J. Obstet. Gynec. 107, 100 (1970).
Napp, J.H., Rothe, A.: Dtsch. med. Wschr. 83, 325 (1958).
Neumann, F.: Handbuch d. experimentellen Pharmakologie Bd. XXII Die Gestagene Teil 1, 680. Berlin-Heidelberg-New York: Springer, 1968.
Østergaard, E., Starup, J.: Acta endocr. (Kbh.) 57, 386 (1968).
Piver, M.S., Bolognese, R.J., Feldman, J.D.: Amer. J. Obstet. Gynec. 97, 579 (1967).
Plotz, J.: In: Brook Lodge Symp. Progesterone. Hrsg. A.C. Barnes, Augusta/Mich.: Brook Lodge Press, 1961.
Poller, L., Thomson, J.M., Tabiowo, A., Priest, C.M.: Brit. Med. J. 1969 I, 554.
Rifkind, A.B., Kulin, H.E., Cargille, C.M., Rayford, P.C., Ross, G.T.: J. clin. Endoer. 29, 506 (1969).
Rivarola, M.A., Camacho, A.M., Migeon, C.J.: J. clin. Endocr. 28, 679 (1968).
Rock, J., Pincus, G., Garcia, C.R.: Science 124, 891 (1956).
Roland, J.: Bull. N.Y. Acad. Med. 45, 681 (1969).
Rubio, B., Berman, E., Larrañaga, A., Guiloff, E., Aguirre, J. J.: Contracept. 1, 303 (1970).
Rust, W.: Zbl. Gynäk. 78, 1363 (1956).
Scommegna, A., Pandya, G.N., Christ, M., Lee, A.W., Cohen, M.R.: Fertil. and Steril. 21, 201 (1970).
Segal, S.J., Croxatto, H.: Vortrag, 27. Meeting of the Amer. Fertil. Soc., Washington D.C., April 1967.
Shelley, W.B., Preucel, R.W., Spoont, S.S.: J. Amer. med. Ass. 190, 35 (1964).
Somayaji, B.N., Paton, A., Price, J.H., Harris, A.B., Flewett, T.H.: Brit. med. J. 1968 II, 281.
Spellacy, W.N., McLeod, A.G.W., Buhi, W.C., Birk, S.A., McCreary, S.A.: Fertil. and Steril. 21, 457 (1970).
Stamm, O., Gerhard, I., Zarro, D.: Bull. Schweiz. Akad. med. Wiss. 25, 472 (1970).
Stoll, B.A.: Brit. med. J. 1969 II, 293.
Svanborg, A., Vikrot, O.: Acta med. scand. 179, 615 (1966).
Swerdloff, R.S., Odell, W.D.: J. clin. Endocr. 29, 157 (1969).
Tatum, H.J., Coutinho, E.M., Filho, J.A., Sant’Anna, A.R.: Amer. J. Obstet. Gynec. 105, 1139 (1969).
Tejuja, S.: Amer. J. Obstet. Gynec. 107, 954 (1970).
Teller, W.M., Mürset, G., Schellong, G.: Acta paediat. scand. 58, 385 (1969).
Turner, S.J.: Obstet, and Gynec. 24, 218 (1964).
Tyler, E.T., Levin, M., Elliot, J., Dolman, H.: Fertil. and Steril. 21, 469 (1970).
Vorys, N., Ullery, J.C., Stevens, V.: Amer. J. Obstet. Gynec. 93, 641 (1965).
Whitty, C.W.M., Hockeday, J.M., Whitty, M.M.: Lancet 1966 I, 856.
Zañartu, J., Pupkin, M., Rosenberg, D., Davansens, A., Guerrero, R., Rodriguez-Bravo, R., Garcia-Hudobro, M.: Fertil. and Steril. 21, 525 (1970).
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Hammerstein, J. (1971). Neue Entwicklungen in der Gestagentherapie. In: Kracht, J. (eds) Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes. Symposion der Deutschen Gesellschaft für Endokrinologie in Hamburg vom 4.–6. März 1971, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95216-6_11
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