Discussion of Jouvet’s Paper

  • Alexander G. Karczmar
  • John C. Eccles


Alexander H. Friedman, Dept. of Pharmacology, Loyola University Medical Center. I would like to throw in another candidate to the monoamine game for Dr. Jouvet. I refer in particular to the work of Professor Monnier (1969) who reported a waking action for histamine. I refer also to some of our own work (Friedman and Walker, 1968) demonstrating certain circadian rhythms in which histamine levels are peaking during the period when the animal is alert and are 180 degrees out of phase with serotonine levels. And I also refer to the actions of antihistamines as sedatives. And to some of the work of Carl Pfeiffers group (1969) on histamine levels in individuals suffering from manic or depressive psychoses. So I think perhaps histamine might be incorporated into this monoamine game, and I would like to hear Dr. Jouvets comments.


Circadian Rhythm Paradoxical Sleep Histamine Level Monoamine Neuron Central Monoamine 
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  1. Friedman, A.H., Walker, C.A.: Orcadian rhythms in rat mid-brain and caudate nucleus biogenic amine levels. J. Physiol. 197, 77–85 (1968).PubMedGoogle Scholar
  2. Monnier, M.: Afferent and central activating effects of histamine on the brain. 4th International Congress on Pharmacology, Basel, Switzerland July 14-18, 1969, P168.Google Scholar
  3. Pfeiffer, C.C., Iliev, V., Goldstein, L. Jenney, E.H.: Correlations between histamine, polyamine levels, EEC and psychiatric ratings in schizophrenia, abstracts. 4th International Congress on Pharm., Basel, Switzerland July 14-18, 1969, P170.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Alexander G. Karczmar
    • 1
  • John C. Eccles
    • 2
  1. 1.Department of Pharmacology and Institute for Mind, Drugs and BehaviorLoyola University of Chicago, Stritch School of MedicineMaywoodUSA
  2. 2.Laboratory of Neurobiology, Department of PhysiologyState University of New York at BuffaloAmherstUSA

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