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Der Exophthalmus produzierende Faktor (EPF)

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Part of the Ergebnisse der Inneren Medizin und Kinderheilkunde book series (KINDERHEILK. NF, volume 30)

Zusammenfassung

1786 beschrieb Parry (1825) zum erstenmal die Symptome des Exophthalmus. In der ersten Hälfte des 19. Jahrhunderts haben dann Flajani (1802), Graves (1835), v. Basedow (1840) und Cooper (1849) auf den Zusammenhang von Augensymptomen und Schilddrüse hingewiesen. Die Suche nach dem pathogenetischen Prinzip des Exophthalmus, insbesondere seine Vergesellschaftung mit Schilddrüsenerkrankungen, hat bis heute wesentliche und richtungsweisende Erkenntnis zutage gefördert. Auch gibt es eine Reihe ausgezeichneter Übersichten, die sich mit der Klinik und den jeweiligen theoretischen Erkenntnissen befassen (Wybar, 1957; Werner, 1960; Smelser, 1961; McGill u. Asper, 1963; Tallberg, 1964; Dobyns, 1966; Horster, 1967). Dennoch ist es bis heute nicht gelungen, den pathogenetischen Mechanismus der endokrinen Ophthalmopathie vollständig zu klären; entscheidende Fragen müssen auch jetzt noch unbeantwortet bleiben.

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© Springer-Verlag, Berlin · Heidelberg 1970

Authors and Affiliations

  1. 1.II. Medizinischen Klinik und PoliklinikUniversität KielDeutschland

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