Skip to main content
SpringerLink
Log in

Funktionsdiagnostik der Hypophysentumoren

Diagnostic of Endocrine Function in Pituitary Tumors

  • Chapter
Oestrogene Hypophysentumoren

Part of the book series: Oestrogene Hypophysentumoren ((ENDOKRINOLOGIE,volume 15))

Summary

Direct estimations of anterior pituitary hormones in blood represent definite progress in diagnosing pituitary diseases, taking into consideration the importance of stimulation tests for recognising functional reserves of these hormones.

However, particularly when determining ACTH and TSH function in tumours of the hypothalamic-hypophyseal area one still has largely to revert to indirect investigations, using the function of peripheral glands as parameter. For example, the various adrenal function tests usually permit an accurate assessment of ACTH function in pituitary tumours and often an insufficiency of ACTH is discovered, although clinical symptoms are not yet detected or are only present to a slight degree. In these cases hormonal substitution has to be considered. The spectrum of these function tests should be as broad as possible.

In regard to the TSH function it has to be pointed out that the indirect parameters available, i. e. the thyroid function tests, are often not sensitive enough and inadequate; consequently, more or less discrete clinical criteria of secondary hypothyroidism can sometimes not be assessed by indirect functional analysis.

Results obtained by these direct and indirect investigations of dieneephalo-hypophyseal function in endocrine active and inactive pituitary tumours demonstrate that the estimation of STH in different function tests (insulin-hypoglycaemic test, glucose tolerance test) are of high diagnostic value. Apart from this, untreated progressive acromegaly apparently is accompanied less frequently by impaired glandotrophic functions (ACTH, TSH and gonado-tropines) than realised so far. On the contrary, in endocrine inactive pituitary tumours glandotrophic insufficiency is much more frequent. In nearly all cases STH, and in a high percentage the gonadotropines, are impaired. More than assumed up to now, ACTH is affected, whereby a partial insufficiency may exist. TSH appears to be less frequently involved, due possibly to the fact that more sensitive diagnostic methods are not yet in practice.

Die in diesem Referat enthaltenen eigenen Untersuchungen wurden mit Hilfe der Deutschen Forschungsgemeinschaft, Bad Godesberg, sowie des Landesamtes für Forschung Nordrhein-Westfalen, Düsseldorf, durchgeführt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Andersen, R. N., and R. H. Egdahl: Effect of vasopressin on pituitaryadrenal secretion in the dog. Endocrinology 74, 538 (1964).

    PubMed  CAS  Google Scholar 

  2. Apostolakis, M., u. K. D. Voigt: Gonadotropine. Stuttgart: Thieme 1965.

    Google Scholar 

  3. Arango, G., W. E. Mayberry, T. J. Hockert, and L. R. Elvebaek: Total and free human serum thyroxine in normal and abnormal thyroid states. Mayo Clin. Proc. 43, 503 (1968).

    PubMed  CAS  Google Scholar 

  4. Bardin, C. W., G. T. Ross, and M. B. Lipsett: Site of action of clomiphene citrate in men: A study of the pituitary-Leydig cell axis. J. clin. Endocr. 27, 1558 (1967).

    PubMed  CAS  Google Scholar 

  5. Baylis, E. M., F. Greenwood, V. James, J. Jenkins, J. Landon, V. Marks, and E. Samols: An examination of the control mechanisms postulated to control growth hormone secretion in man. In: Growth Hormone, Excerpta med. Found. (Amst.) S. 89 (1968).

    Google Scholar 

  6. Beck, P., J. H. T. Koumans, C. A. Winterling, M. G. Stein, W. H. Daughady, and D. M. Kipnis: Studies of insulin and growth hormone secretion in human obesity. J. Lab. clin. Med. 64, 654 (1964).

    PubMed  CAS  Google Scholar 

  7. Beck, P., J. H. T. Koumans, C. A. Winterling, M. G. Stein, W. H. Daughady, and D. M. Kipnis M. L. Parker, and W. H. Daughaday: Paradoxical hypersecretion of growth hormone in response to glucose. J. clin. Endocr. 26, 463 (1966).

    PubMed  CAS  Google Scholar 

  8. Best, J., K. J. Catt, and H. G. Burger: Non specifity of arginine infusion as a test for growth hormone secretion. Lancet 1968, 20, 124.

    Google Scholar 

  9. Bethge, H.: Die Funktionsdiagnostik des Hypothalamus-Hypophysen-Nebennieren-rindensystems. Habilitationsschrift, Düsseldorf, 1967.

    Google Scholar 

  10. Bethge, H. K. Irmscher u. H. Zimmermann: Das Verhalten der Corticosteroide im Plasma während der Insulinhypoglykämie und unter Lysin-Vasopressin als Funktions-prüfung des Hypothalamus-Hypophysen-Nebennierenrinden-Systems. Acta endocr. (Kbh.) 55, 622 (1967).

    CAS  Google Scholar 

  11. Bethge, H. K. Irmscher u. H. Zimmermann, W. Winkelmann u. H. Zimmermann: Die Beurteilung der gestörten Nebennieren-rindenfunktion mit einer einfachen Methode zur Bestimmung der 11-Hydroxy-corticosteroide im Plasma. Klin. Wschr. 43, 1274 (1965).

    Google Scholar 

  12. Bierich, J. R., D. Schonberg u. E. Eckler: Untersuchungen zur Dynamik des Hypo-physen-Nebennierenrinden-Systems. Dtsch. med. Wschr. 87, 884 (1962).

    Google Scholar 

  13. Binoux, M., F. Girard, et P. Mozziconacci: Variations de l’activité corticotrope et de Cortisol plasmatique au cours des nycthémère et sous l’influence de la metopirone et de l’ACTH. Ann. Bédiat. 41, 466 (1965).

    Google Scholar 

  14. Boden, G., J. S. Soeldner, J. Steinke, and G. W. Thorn: Serum human growth hormone (HGH) response to i. v. glucose: Diagnosis of acromegaly in females and males. Metabolism 8, 1 (1968).

    Google Scholar 

  15. Brinck-Johnsen, T., J. H. Solem, K. Brinck-Johnsen, and P. Ingvaldsen: The 17-hydroxy-corticosteroid response to corticotrophin, metopiron and bacterial pyrogen. Acta med. scand. 173, 129 (1963).

    PubMed  CAS  Google Scholar 

  16. Condliffe, P. G., and D. Bobbins: Pituitary thyroid-stimulating hormone and other thyroid-stimulating substances. In: Hormones in Blood, 2nd Edition, Vol. 1, S. 333. London, New York: Academic Press 1968.

    Google Scholar 

  17. McCullagh, E. P.: Sex hormone deficiencies — some clinical considerations. Recent Progr. Hormone Res. 2, 295 (1948).

    CAS  Google Scholar 

  18. Czarny, D., V. H. T. James, and J. Landon: Corticosteroid and growth hormone response to synthetic lysinevasopressin, natural vasopressin, saline solution and venepuncture. Lancet 1968, 20, 126.

    Google Scholar 

  19. Demura, H., C. D. West, C. A. Nugent, K. Nakagawa, and F. H. Tyler: A sensitive radioimmunoassay for plasma ACTH levels. J. clin. Endocr. 26, 1297 (1966).

    PubMed  CAS  Google Scholar 

  20. Derot, M., G. Rosselin, R. Assan, P. Freychet, and G. Tschobroutsky: Plasma levels of growth hormone and insulin in acromegaly. Ann. Endocr. (Paris) 27, 776 (1966).

    CAS  Google Scholar 

  21. Drucker, W. O., B. M. Segal, A. L. Verde, and N. P. Christy: Adrenocorticotrophic activity in plasma of patients with acromegaly. Amer. J. Med. 43, 383 (1967).

    PubMed  CAS  Google Scholar 

  22. Earll, J. M., L. L. Sparks, and P. H. Forsham: Glucose suppression of serum growth hormone in the diagnosis of acromegaly. J. Amer. med. Ass. 201, 628 (1967).

    CAS  Google Scholar 

  23. Franchimont, P.: Le dosage des hormones hypophysares somatotrope et gonadotrope et son application en clinique. S. A. Brüssel: Editions Arscia 1966.

    Google Scholar 

  24. Franchimont, P.: Le dosage radioimmunologique de l’hormone de croissance humaine. Cah. méd. Lyonnais. 44, 887 (1968).

    Google Scholar 

  25. Franchimont, P. et J. J. Legros: Influence des hormones posthypophysaires sur le taux de la somato-trophine et les gonadotrophines chez l’homme. Ann. Endocr. (Paris) 30, 9 (1969).

    Google Scholar 

  26. Franchimont, P. et J. J. Legros: Wachstumshormonspiegel und Gonadotropinspiegel bei Patienten mit Hypophysentumoren vor und nach Bestrahlungstherapie. 15. Symp. dtsch. Ges. für Endokrinologie, Köln 1969.

    Google Scholar 

  27. Fraser, R., and A. D. Wright: Standard procedures for assessing hypersecretion or secretory capacity for human growth hormone using the radioimmunoassay. Postgrad. med. J. 44, 53 (1968).

    PubMed  CAS  Google Scholar 

  28. Frohman, L. A., E. S. Horton, and H. E. Lebovitz: Growth hormone releasing action of a Pseudomonas endotoxin (Piromen). Metabolism 16, 57 (1967).

    PubMed  CAS  Google Scholar 

  29. Gagliardino, J. J., J. D. Bailey, and J. M. Martin: Effect of vasopressin on serum levels of HGH. Lancet 1967, 24, 1357.

    Google Scholar 

  30. Garcia, J. F., J. A. Lintfoot, E. Manougian, J. L. Born, and J. H. Lawrence: Plasma growth hormone studies in normal individuals and acromegalic patients. J. clin. Endocr. 27, 1395(1967).

    PubMed  CAS  Google Scholar 

  31. Garmendia, F., W. E. Vaubel u. E. F. Pfeiffer: Über das Verhalten der endogenen ACTH-Aktivität im menschlichen Plasma nach enzymatischer Blockade der Cortisolsynthese mit Metopiron (SU 4885). Klin. Wschr. 41, 517 (1963).

    Google Scholar 

  32. Gold, E. M., J. R. Kent, and P. H. Forsham: Clinical use of a new diagnostic agent, metopyrapone (SU 4885) in pituitary and adrenocortical disorders. Ann. intern. Med. 54, 175 (1961).

    PubMed  CAS  Google Scholar 

  33. Gordon, D. A., F. M. Hill, and C. Ezrin: Acromegaly: A review of 100 cases. Canad. med. Ass. J. 87, 1106 (1962).

    PubMed  CAS  Google Scholar 

  34. Greenwood, F. C., and J. Landon: Growth hormone secretion in response to stress in man. Nature (Lond.) 210, 540 (1966).

    CAS  Google Scholar 

  35. Greenwood, F. C., and J. Landon and T. C. B. Stamp: The plasma sugar, free fatty acid, Cortisol and growth hormone response to insulin. I. In control subjects. J. clin. Invest. 45, 429 (1966).

    PubMed  CAS  Google Scholar 

  36. Gwinup, G.: Studies on the mechanism of vasopressin-induced steroid secretion in man. Metabolism 14, 1282 (1965).

    PubMed  CAS  Google Scholar 

  37. Gwinup, G. T. Steinberg, C. G. King, and J. Vernikos-Danellis: Vasopressin-induced ACTH-secretion in man. J. clin. Endocr. 27, 927 (1967).

    PubMed  CAS  Google Scholar 

  38. Hamwi, G. J., T. G. Skillmann, and K. C. Tufts: Acromegaly. Amer. J. Med. 29, 690 (1960).

    CAS  Google Scholar 

  39. Hedge, G. A., M. B. Yates, R. Marcus, and F. E. Yates: Site of action of vasopressin in corticotrophin release. Endocrinology 79, 328 (1966).

    PubMed  CAS  Google Scholar 

  40. Herberg, L., C. Frohn, H. G. Solbachu. H. Zimmermann: Der Einfluß der Metopirondosis auf die Corticosteroidausscheidung in Abhängigkeit vom Körpergewicht. 15. Symp. d. Dtsch. Ges. f. Endokrinologie, Köln 1969.

    Google Scholar 

  41. Hökfeld, B., and R. Luft: The effect of suprasellar tumors on the regulation of adreno-cortical function. Acta endocr. (Kbh.) 32, 177 (1959).

    Google Scholar 

  42. Horster, F. A.: Endokrine Ophthalmopathie. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  43. Horster, F. A.: D. Reinwein, and D. Sieper: TSH and LATS in the serum of normal persons during longstanding application of antithyroid drugs. Im Druck (1969).

    Google Scholar 

  44. Hunter, W. M., J. A. R. Friend, and J. A. Strong: The diurnal pattern of plasma growth hormone concentration in adults. J. Endocr. 34, 139 (1966).

    PubMed  CAS  Google Scholar 

  45. Ikkos, D., H. Ljunggren, and R. Luft: Basal metabolic rate in relation to body size and cell mass in acromegaly. Acta endocr. (Kbh.) 21, 237 (1956).

    CAS  Google Scholar 

  46. Ingbar, S. H., L. E. Braverman, N. A. Dawber, and G. Y. Lee: A new method for measuring the free thyroid hormone in human serum and an analysis of the factors that influence its concentration. J. clin. Invest. 44, 1679 (1965).

    PubMed  CAS  Google Scholar 

  47. Irie, M., M. Sakuma, K. Shizume, and K. Nakao: Study on the evaluation of activity in acromegaly. Endocr. jap. 14, 17 (1967).

    PubMed  CAS  Google Scholar 

  48. Jenkins, J. S.: The pituitary-adrenal response to pyrogen. In: Memoirs of the Society for Endocrinology, Vol. 17: “The investigation of hypothalamic-pituitary-adrenal function”. Eds. V. H. T. James and J. Landon, S. 205. Cambridge: University Press 1968.

    Google Scholar 

  49. Jenkins, J. S.:, and W. Else: Pituitary-adrenal function tests in patients with untreated pituitary tumors. Lancet 1968 II, 940.

    Google Scholar 

  50. Kaplan, N. M.: Assessment of pituitary ACTH secretory capacity with metopiron: II. Comparison with other tests. J. clin. Endocr. 23, 935 (1963).

    Google Scholar 

  51. Karp, M., K. Pertzelan, M. Doron, A. Kowaldo-Silbergeld, and Z. Laron: Changes in blood glucose and plasma insulin, free fatty acids, growth hormone and 11-hydroxy-corticosteroids during intramuscular vasopressin test in children and adolescents. Acta endocr. (Kbh.) 58, 545 (1968).

    CAS  Google Scholar 

  52. Klein, E.: Der endogene Jodhaushalt des Menschen. Stuttgart: Thieme 1960.

    Google Scholar 

  53. Klinefelter, H. F., F. Albright, and G. C. Griswold: Experience with quantitative test for normal or decreased amounts of follicle-stimulating hormone in urine in endocrinological diagnosis. J. clin. Endocr. 3, 529 (1943).

    CAS  Google Scholar 

  54. Köhler, P. O., B. W. O’Mallay, P. L. Rayford, M. B. Lipsett, and W. D. Odell: Effect of pyrogen on blood levels of pituitary tropic hormones. Observations of the usefulness of the growth hormone response in the detection of pituitary disease. J. clin. Endocr. 27, 219 (1967).

    PubMed  Google Scholar 

  55. Krieger, D. T., S. Glick, A. Silverberg, and H. P. Krieger: A comparative study of endocrine tests in hypothalamic disease. Circadian periodicity of plasma 11-OHCS levels, plasma 11-OHCS and growth hormone response to insulin hypoglycemia and mety-rapone responsiveness. J. clin. Endocr. 28, 1589 (1968).

    PubMed  CAS  Google Scholar 

  56. Krieger, D. T., S. Glick, A. Silverberg, and H. P. Krieger:, H. Koloony, and H. P. Krieger: Methopyrapone tests in hypothalamic pituitary disease. J. clin. Endocr. 24, 1169 (1964).

    PubMed  CAS  Google Scholar 

  57. Krieger, D. T., S. Glick, A. Silverberg, and H. P. Krieger:, and H. P. Krieger: Circadian variation of the plasma 17-hydroxycorticosteroids in central nervous system disease. J. clin. Endocr. 26, 929 (1966).

    PubMed  CAS  Google Scholar 

  58. Lamberg, B. A., J. Ripatti, A. Gordin, H. Juustila, A. Sivula, and G. Björkesten: Chromophobe pituitary adenoma with acromegaly and TSH-induced hyperthyroidism associated with parathyroid adenoma. Acta endocr. (Kbh.) 60,157 (1969).

    CAS  Google Scholar 

  59. Landon, J., and F. C. Greenwood: Homologous radioimmunoassay for plasma levels of corticotrophin in man. Lancet 1968 I, 273.

    CAS  Google Scholar 

  60. Landon, J., and F. C. Greenwood, T. C. B. Stamp, and V. Wynn: The plasma sugar, free fatty acid, Cortisol and growth hormone response to insulin and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J. clin. Invest. 45, 437 (1966).

    PubMed  CAS  Google Scholar 

  61. Landon, J., and F. C. Greenwood, T. C. B. Stamp, and V. Wynn: V. H. T. James, and D. J. Stoker: Plasma Cortisol response to lysine-vasopressin. Comparison with other tests of human pituitary adrenocortical function. Lancet 1965 II, 1156.

    Google Scholar 

  62. Lazarus, L.: The investigation of hypopituitarism. Austr. Ann. Med. 16, 107 (1967).

    CAS  Google Scholar 

  63. Lederer, J., et R. Pasleau: La fonction cortieo-surrénalienne des acromegales. Ann. Endocr. (Paris) 24, 897 (1963).

    CAS  Google Scholar 

  64. Lemon, H. M.: Cortisone-thyroid therapy of metastatic mammary cancer. Ann. intern. Med. 46, 457 (1957).

    PubMed  CAS  Google Scholar 

  65. Lessof, M. H., Mc. H., Young, and F. C. Greenwood: Growth hormone in secretion of obese subjects. Guy’s Hosp. Rep. 115, 65 (1966).

    CAS  Google Scholar 

  66. Liddle, G. W., H. L. Estep, J. W. Kendall, W. C. Williams, and A. W. Townes: Clinical application of a new test of pituitary reserve. J. clin. Endocr. 19, 875 (1959).

    PubMed  CAS  Google Scholar 

  67. Liebermeister, H., H. G. Solbach, W. H. Schilling, R. Rüenauver, H. Meissner, D. Grüneklee, L. Herberg, and H. Daweke: Serum insulin in acromegaly. Comparative investigations by a radio-immunological method and the biological methods using adipose and muscle tissue. Diabetologia 4, 195 (1968).

    PubMed  CAS  Google Scholar 

  68. Litta-Modignani, R., and M. Badoni: Metyrapone and pyrogen tests in hyperadrenocorticism: Evaluation of blood corticotrophin levels. J. Endocr. 42, 245 (1968).

    PubMed  CAS  Google Scholar 

  69. Loraine, J. A.: The clinical application of hormone assay. Ed.: Loraine, J. A., Edinburgh: Livingstone 1958.

    Google Scholar 

  70. Loraine, J. A.: The effect of steroid hormones on pituitary function in man as judged by urinary gonadotrophin assays. In: Int. Congr. on Hormonal Steroids, Mailand 1962. M. D. Conolly, Excerpta med. Found. (Amst.) (1962).

    Google Scholar 

  71. Luft, R., and E. Cerasi: Human growth hormone as a regulator of blood glucose concentration and as diabetogenic substance. Vortrag IV. Acta Endocr. Congress, Helsinki 8.—12. VIII. 1967.

    Google Scholar 

  72. Maddock, W. O., J. D. Chase, and W. O. Nelson: The effects of large doses of cortisone on testicular morphology and urinary gonadotropin, estrogen and 17-ketosteroid excretion. J. Lab. clin. Med. 41, 608 (1953).

    PubMed  CAS  Google Scholar 

  73. Marks, V., and M. Summers: Pituitary-adrenal function in cases of pituitary tumour. Brit. med. J. 2, 155 (1963).

    PubMed  CAS  Google Scholar 

  74. Martin, F. I. R.: Pituitary deficiency in patients with pituitary tumors. Aust. Ann. Med. 15, 40 (1966).

    PubMed  CAS  Google Scholar 

  75. Mautalen, C. A., R. C. Mellinger, and R. W. Smith: Lipolytic effect of growth hormone in acromegaly. J. clin. Endocr. 28, 1031 (1968).

    PubMed  CAS  Google Scholar 

  76. Merimee, T. J., D. A. Lillierap, and D. Rabinowitz: Effect of arginine on serum levels of human growth hormone. Lancet 1965 II, 668.

    Google Scholar 

  77. Merimee, T. J., D. A. Lillierap, and D. Rabinowitz, D. Rabinowitz, L. Riggs, J. A. Burgess, D. L. Rimoin, and V. A. McKusick: Plasma growth hormone after arginine infusion. New Engl. J. Med. 276, 434 (1967).

    PubMed  CAS  Google Scholar 

  78. Miller, M., and A. M. Moses: Effect of temperature and dexamethasone on the plasma 17-hydroxycorticoid and growth hormone response to pyrogen. J. clin. Endocr. 28, 1056 (1968).

    PubMed  CAS  Google Scholar 

  79. Moses, A. M., and M. Miller: Stimulation and inhibition of ACTH release inpatients with pituitary disease. J. clin. Endocr. 28, 1581 (1968).

    PubMed  CAS  Google Scholar 

  80. Nieman, E. A., J. Landon, and V. Wynn: Endocrine function in patients with untreated chromophobe adenomas. Quart. J. Med., New Series XXXYI, 143, 357 (1967).

    Google Scholar 

  81. Oberdisse, K.: Die partielle Vorderlappeninsuffizienz. 4. Sympos. dtsch. Ges. f. Endo-krinologie 1956, S. 40. Berlin-Göttingen-Heidelberg: Springer 1957.

    Google Scholar 

  82. Oberdisse, K., u. W. Tönnis: Pathophysiologie, Klinik und Behandlung der Hypophysenadenome. Ergebn. inn. Med. Kinderheilk. N. F. 4, 976 (1953).

    Google Scholar 

  83. Odell, W. D.: Isolated deficiencies of anterior pituitary hormones. J. Amer. med. Ass. 197, 1006 (1966).

    CAS  Google Scholar 

  84. Odell, W. D., G. Ross, and P. Rayford: Radioimmunoassay for LH in human plasma or serum-physiological studies. J. clin. Invest. 46, 248 (1967).

    PubMed  CAS  Google Scholar 

  85. Oppenheimer, J. H., L. V. Fisher, and J. W. Jailer: Disturbance of the pituitary-adrenal interrelationship in diseases of the central nervous system. J. clin. Endocr. 21, 1023 (1961).

    PubMed  CAS  Google Scholar 

  86. Peterson, N. T., R. A. Midgley, and R. B. Jaffe: Regulation of human gonadotropin. III. LH and FSH in sera from adult males. J. clin. Endocr. 28, 1473 (1968).

    PubMed  CAS  Google Scholar 

  87. Pfeiffer, E. E., u. E. Melani: Menschliches Wachstumshormon. Darstellung, Bestimmung im Blute und klinische Bedeutung. Dtsch. med. Wschr. 93, 846 (1968).

    PubMed  CAS  Google Scholar 

  88. Quabbe, H. J., E. Schilling, and H. Helge: Pattern of growth hormone secretion during a 24-hour fast in normal adults. J. clin. Endocr. 26, 1173 (1966).

    PubMed  CAS  Google Scholar 

  89. Rabinowitz, D., T. J. Merimee, J. K. Nelson, R. B. Schultz, and J. A. Burgess: The influence of proteins and amino acids on growth hormone release in man. In: Growth Hormone. S. 105. Excerpta med. Found. (Amst.) 1968.

    Google Scholar 

  90. Rabkin, M. T., and A. G. Frantz: Hypopituitarism: A study of growth hormone and other endocrine functions. Ann. intern. Med. 64, 1197 (1966).

    PubMed  CAS  Google Scholar 

  91. Reinwein, D., u. H. Durrer: Untersuchungen über den Tyrosinspiegel im Blut bei gestörter Schilddrüsenfunktion. Verh. dtsch. Ges. inn. Med. 74, 1206 (1968).

    PubMed  CAS  Google Scholar 

  92. Roginsky, M. S., J. C. Shaver, and N. P. Christy: A study of adreno-cortical function in acromegaly. J. clin. Endocr. 26, 1101 (1966).

    PubMed  CAS  Google Scholar 

  93. Roth, J., S. M. Gliek, P. Cuatrecasas, and C. S. Hollander: Acromegaly and other disorders of growth hormone secretion. Ann. intern. Med. 66, 760 (1967).

    PubMed  CAS  Google Scholar 

  94. Roth, J., S. M. Gliek, P. Cuatrecasas, and C. S. Hollander, R. S. Yalow, and S. A. Berson: Hypoglycemia: Potent stimulus to secretion of growth hormone. Science 140, 987 (1963).

    PubMed  CAS  Google Scholar 

  95. Schneeberg, N. G., and P. C. Kansal: Commentary on an propesed TSH-reserve test. J. clin. Endocr. 26, 579 (1966).

    PubMed  CAS  Google Scholar 

  96. Schröder, K. E., S. Raptis, R. Conrads u. E. F. Pfeiffer: Akromegalie und Wachstums-hormon im Serum. 15. Symp. dtsch. Ges. f. Endokrinologie, Köln 1969.

    Google Scholar 

  97. Solbach, H. G.: Die Gonadotropine beim männlichen Hypogonadismus. Habilitationsschrift, Düsseldorf 1965.

    Google Scholar 

  98. Solbach, H. G., W. Wiegelmann u. P. Franchimont: Publikation im Druck (1969).

    Google Scholar 

  99. Solem, J. H., and T. Brinck-Johnsen: Indirect estimation of pituitary corticotrophin reserve in man by use of an adrenocortical 11 -ß-hydroxylase inhibitor (SU 4885 Ciba). Acta med. scand. 170, 89 (1961).

    CAS  Google Scholar 

  100. Soval, A. R., and L. J. Soffer: The influence of cortisone and adrenocorticotropin on urinary gonadotropin excretion. J. clin. Endocr. 11, 677 (1951).

    Google Scholar 

  101. Staib, W., u. W. Teller: Bestimmung der reduzierenden Corticosteroide im Harn. Röntgen- u. Lab.-Praxis 13, L 151 (1960).

    Google Scholar 

  102. Strott, C. A., K. Nakagawa, H. Nankin, and C. A. Nugent: A phenylalanine-lysine vasopressin test of ACTH release. J. clin. Endocr. 27, 448 (1967).

    PubMed  CAS  Google Scholar 

  103. Studer, H.: TSH-Reservetest mit Carbimazol. Helv. med. Acta 29, 275 (1962).

    PubMed  CAS  Google Scholar 

  104. Takebe, K., A. Kuroshima, M. Yamamoto, Y. Horiuchi, S. Itoh, C. Y. Bowers, and A. V. Schally: Effect of lysine vasopressin dimer on corticotropin release in man. J. clin. Endoer. 28, 73 (1968).

    CAS  Google Scholar 

  105. Tucci, J. R., E. A. Espiner, P. I. Jagger, D. P. Lauler, and G. W. Thorn: Vasopressin in the evaluation of pituitary-adrenal function. Ann. intern. Med. 69, 191 (1968).

    PubMed  CAS  Google Scholar 

  106. Wegienka, L. C., G. M. Grodsky, J. H. Karam, S. G. Grasso, and P. H. Forsham: Comparison of insulin and 2-deoxy-d-glucose induced glucopenia as stimulators of growth hormone secretion. Metabolism 16, 245 (1967).

    PubMed  CAS  Google Scholar 

  107. Wiegelmann, W., K. Irmscher, P. Franehimont, H. Bethge u. H. G. Solbach: Hormon-untersuchungen bei einem Fall von idiopathischer glandotroper Hypophysenvorderlappeninsuffizienz mit erhaltener isolierter STH-Produktion. 15. Symp. dtsch. Ges. f. Endokrinologie, Köln 1969.

    Google Scholar 

  108. Wiegelmann, W., K. Irmscher, P. Franehimont, H. Bethge u. H. G. Solbach, H. G. Solbach, P. Franchimont u. J. J. Legros: Radioimmunologische Bestimmungen von menschlichem Wachstumshormon (STH) im Serum bei 62 Patienten mit einer Akromegalie. 75. Tagung dtsch. Ges. f. inn. Medizin, Wiesbaden 1969 (Im Druck).

    Google Scholar 

  109. Wilber, J. F., and W. D. Odell: Influence of tapazole upon serum TSH. J. clin. Endocr. 25, 1407 (1965).

    PubMed  CAS  Google Scholar 

  110. Winkelmann, W., H. Bethge, K. Hackenberg u. H. G. Solbach: Cortisol- und Cortico-steronsekretion bei Hypophysentumoren. 15. Symp. d. dtsch. Ges. f. Endokrinologie, Köln 1969.

    Google Scholar 

  111. Winkelmann, W., H. Bethge, K. Hackenberg u. H. G. Solbach, H. Schmitt, H. G. Solbach, D. Vorster u. H. Zimmermann: Cortisol- und Cortico-steronsekretion bei der Akromegalie. Klin. Wschr. 46, 1008 (1968).

    PubMed  CAS  Google Scholar 

  112. Wynn, V.: The assessment of hypothalamic-pituitary-adrenocortical function in man. In: Memoirs of the Society for Endocrinology, Vol. 17: “The investigation of hypo-thalamic-pituitary-adrenal function”. Eds. V. H. T. James and J. Landon, S. 213. Cambridge: University Press 1968.

    Google Scholar 

  113. Wyss, F., u. H. Studer: Die pathophysiologische Bedeutung der eingeschränkten Lei-stungsreserve des Hypophysen-Schüddrüsensystems. Schweiz, med. Wschr. 93, 1 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 2. Medizinische Klinik und Poliklinik, Abteilung für Endokrinologie, Universität Düsseldorf, Deutschland

    H. G. Solbach, H. Bethge & H. Zimmermann

Authors
  1. H. G. Solbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Bethge
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Zimmermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pathologisches Institut der Universität, 6300, Gießen, Klinikstraße 32g, Deutschland

    Joachim Kracht

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Solbach, H.G., Bethge, H., Zimmermann, H. (1969). Funktionsdiagnostik der Hypophysentumoren. In: Kracht, J. (eds) Oestrogene Hypophysentumoren. Oestrogene Hypophysentumoren, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95126-8_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95126-8_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95127-5

  • Online ISBN: 978-3-642-95126-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation