Summary
The substrate was injected into an ovarian artery in vivo. Over 15 min. the ovarian veinons blood was collected and analyzed for free and conjugated steroids. In plasma 1.6%, in ovarian tissue 12% of total radioactivity were found to be free steroids, indicating sulfatase activity. In this fraction only progesterone and androstenedione besides pregnenolone could be isolated. After solvolysis of sulfoconjugates only delta-5-metabolites such as dehydroepi-androsterone and androstenediol were detected. It was concluded that free and sulfoconjugated pregnenolone underwent different metabolism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Knapstein, P., Beck, L., Oertel, G.W. (1969). In vivo Perfusion eines menschlichen Ovars mit 7α-3H-Pregnenolon-sulfat. In: Kracht, J. (eds) Oestrogene Hypophysentumoren. Oestrogene Hypophysentumoren, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95126-8_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-95126-8_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-95127-5
Online ISBN: 978-3-642-95126-8
eBook Packages: Springer Book Archive