The Limitations and Special Advantages of the Perfused Liver in Relation to the Synthesis and Catabolism of the Plasma Proteins

  • Arthur Hugh Gordon
Conference paper

Abstract

Although a great deal of information has accumulated concerning the numerous stages involved in the synthesis of proteins little evidence is as yet available concerning the nature of the factors which operate in vivo to control the rates of synthesis of individual proteins. Investigation of such factors can only be carried out either in vivo or by making use of a particular organ maintained in a state approximating to physiological normality. In the case of the liver such a condition can be achieved without great difficulty by perfusion with heparinised blood.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen, S., and A. H. Gordon: Biochem. J. 70, 544 (1958).PubMedGoogle Scholar
  2. Darcy, D. A.: Brit. J. exp. Path. 45, 281 (1964).PubMedGoogle Scholar
  3. ——— Brit. J. exp. Path. 46, 155 (1965).Google Scholar
  4. Fisher, M. M., and M. Kerly: J. Physiol. 174, 273 (1964).PubMedGoogle Scholar
  5. Freeman, T., and A. H. Gordon: Clin. Sci. 26, 17 (1964).PubMedGoogle Scholar
  6. Freeman, T., and J. H. Humphrey: Brit. J. exp. Path. 39, 459 (1958).PubMedGoogle Scholar
  7. Gordon, A. H.: Nature 189, 727 (1961).PubMedCrossRefGoogle Scholar
  8. ——— Europ. J. Cancer 2, 19 (1966).Google Scholar
  9. ———, and D. A. Darcy: Brit. exp. Path. 48, 81 (1967).Google Scholar
  10. ———, and L. E. Mutschler: Protides of the biological fluids. Proc. of the 12th Colloquium, p. 475 (1964).Google Scholar
  11. Hamashima, Y., J. G. Harter, and A. H. Coons: J. cell. Biol. 20, 271 (1964).PubMedCrossRefGoogle Scholar
  12. Mcfarlane, A. S.: Biodiem. J. 89, 277 (1963).Google Scholar
  13. Marsh, J. B., and D. L. Drabkin: J. biol. Chem. 230, 1073 (1958).PubMedGoogle Scholar
  14. Miller, L. L., C. G. Bly, M. L. Watson, and W. F. Bale: J. exp. Med. 94, 431 (1951).PubMedCrossRefGoogle Scholar
  15. Mutschler, L. E., and A. H. Gordon: Biochem. biophys. acta 130, 486 (1966).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • Arthur Hugh Gordon
    • 1
  1. 1.National Institute for Medical ResearchLondon, N.W. 7UK

Personalised recommendations