Zusammenfassung
Suchen wir in einem Lehrbuch der Biochemie nach nierenspezifischen biochemischen Prozessen, so werden wir enttäuscht. Es ist bis heute kein Stoffwechselvorgang bekannt, der sich ausschließlich in der Niere abspielt. Wie ist es nun aber erklärbar, daß die Niere mit denselben Enzymen, wie sie in der Leber vorkommen, so unerhört spezialisierte Transportaufgaben zu erfüllen vermag ? Diese Frage kann heute nicht beantwortet werden, vor allem weil unsere Methoden zur Erforschung des Stoffwechsels der Nierenzellen viel zu grob und zu undifferenziert sind. Die Unzulänglichkeiten der Methoden gehen aus folgendem Vergleich hervor: Analysieren wir den Leberstoffwechsel mit Hilfe von Schnitten oder Homogenaten, so dürfen wir das Resultat als ziemlich repräsentativ für „die Leberzelle” betrachten. Bei der gesunden und erst recht bei der kranken Niere haben wir es aber mit einem Organgemisch zu tun, einem Konglomerat langgezogener und ineinander verschlungener Orgänchen, den Nephronen. Auch für den Biochemiker gilt, was Oliver (1950) unter dem Titel “When is a kidney not a kidney?” den Physiologen kritisch vorwarf:
“There is no ‘kidney’, either structural of functional in chronic renal disease. The only useful or meaningful purpose of the word ist to designate a mass of tissue which, except in topographical anatomic or surgical problems, has no significance until we analyze its constituents. And then it vanishes into the disparity of thousands of fantastically altered organs of strange design and anomalous behavior … Liquidate the ‘kidney’ and entitle the next symposium ‘The Nephrons in Health and Disease’.”
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Andres, R., G. Cader, and K.L. Zierler: The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J. clin. Invest. 35, 671–682 (1956).
Atchley, D.W., R.F. Loeb, D.W. Richards, E.M. Benedict, and M.E. Driscoll: On diabetic acidosis; detailed study of electrolyte balances following withdrawal and reestablishment of insulin therapy. J. clin. Invest. 12, 297–326 (1933).
Barclay, J.A., and I.D. Singh: The isolated renal glomerulus. Acta med. scand. 154, 483–490 (1956).
Barker, E.S., A.P. Crosley, and J.K. Clark: Respiratory quotients of human kidney in vivo. J. appl. Physiol. 18, 815–817 (1963).
Berliner, R. W., T. J. Kennedy, and J. Orloff: Relationship between acidification of the urine and potassium metabolism. Effect of carbonic anhydrase inhibition on potassium excretion. Amer. J. Med. 11, 274–282 (1951).
Berliner, R.W., and J. Orloff: Carbonic anhydrase inhibitors. Pharmacol. Rev. 8, 137–174 (1956).
Bernheim, F.: Note on the action of copper and Phenylhydrazine on certain dehydrogenases. J. biol. Chem. 133, 485–489 (1940).
Beyer, K.H., R.H. Painter, and V.D. Wiebelhaus: Enzymatic factors in renal tubular secretion of phenol red. Amer. J. Physiol. 161, 259–267 (1950).
Bing, R. J., A. Siegel, I. Ungar, and M. Gilbert: Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Amer. J. Med. 16, 504–515 (1954).
Bosáčková, J.: The transport of inorganic ions and p-aminohippurate in isolated cells of the renal cortex of the rabbit. Biochim. biophys. Acta (Amst.) 71, 345–354 (1963).
Browne, M. J., M.W. Pitts, and R.F. Pitts: Alkaline phosphatase activity in kidneys of glomerular and aglomerular marine teleosts. Biol. Bull. 99, 152–156 (1950).
Cameron, G., and R. Chambers: Direct evidence of fundtion in kidney of an early human fetus. Amer. J. Physiol. 123, 482–485 (1938).
Cargill, W. H., and J. B. Hickam: The oxygen consumption of the normal and the diseased human kidney. J. clin. Invest. 28, 526–532 (1949).
Chambers, R., L.V. Beck, and M. Belkin: Secretion in tissue cultures. I. Inhibition of phenol red accumulation in the chick kidney. J. cell. comp. Physiol. 6, 425–439 (1935).
Chambers, R., and G. Cameron: Intracellular hydrion concentration studies. VII. The secreting cells of the mesonephros in the chick. J. cell. comp. Physiol. 2, 99–103 (1932).
Chambers, R., and R.T. Kempton: Indications of function of the chick mesonephros in tissue culture with phenol red. J. cell. comp. Physiol. 8, 131–160 (1933).
Clark, J.K., and H.G. Barker: Studies of renal oxygen consumption in man. I. The effect of tubular loading (PAH), water diuresis and osmotic (mannitol) diuresis. J. clin. Invest. 30, 745–750 (1951).
Cohen, J. J.: High respiratory quotient of dog kidney in vivo. Amer. J. Physiol. 199, 560–568 (1960).
Copenhaver, J.H., and R.P. Forster: Displacement characteristics of intracellularly accumulated p-aminohippurate in a mammalian renal transport system in vitro. Amer. J. Physiol. 195, 327–330 (1958).
Cross, R. J., and J.V. Taggart: Renal tubular transport: accumulation of p-aminohippurate by rabbit kidney slices. Amer. J. Physiol. 161, 181–190 (1950).
Crumpler, H.R., C.E. Dent, H. Harris, and R.G. Westall: β:-aminoisobutyric acid (α-methyl-ß- alanine): a new amino-acid obtained from human urine. Nature (Lond.) 167, 307–308 (1951).
Davies, B.M. A., and J. Yudkin: Role of glutaminase in the production of urinary ammonia. Nature (Lond.) 167, 117 (1951).
~ Studies in biochemical adaptation. Origin of urinary ammonia as indicated by effect of chronic acidosis and alkalosis on some renal enzymes in rat. Biochem. J. 52, 407–412 (1952).
Deetjen, P., u. K. Kramer: Na-Rückresorption und O2-Verbrauch der Niere. Klin. Wschr. 88, 680 (1960).
Dent, C.E., and H. Harris: Genetics of “cystinuria”. Ann. Eugen. (Lond.) 16, 60–87 (1951).
Dickens, F., and H. Weil-Malherbe: Metabolism of normal and tumour tissue; note on metabolism of medulla of kidney. Biochem. J. 30, 659–660 (1936).
Eggleton, M.G., J.R. Pappenheimer, and F.R. Winton: The influence of diuretics on the osmotic work done and on the efficiency of the isolated kidney of the dog. J. Physiol. (Lond.) 97, 363–382 (1940).
Evered, D.F.: The excretion of amino acids by the human. A quantitative study with ion-exchange chromatography. Biochem. J. 62, 416–427 (1956).
Føiling, A.: On the mechanism of ammonium chloride acidosis. Acta med. scand. 71, 221–279 (1929).
Forster, R.P.: Use of thin kidney slices and isolated renal tubules for direct study of cellular transport kinetics. Science 108, 65–67 (1948).
Forster, R.P., and J. H. Copenhaver: Intracellular accumulation as an active process in a mammalian renal transport system in vitro. Energy dependence and competitive phenomena. Amer. J. Physiol. 186, 167–171 (1956).
Forster, R.P., and J.V. Taggart: Use of isolated renal tubules for the examination of metabolic processes associated with active cellular transport. J. cell, comp. Physiol. 36, 251–270 (1950).
Foulkes, E.C., and B.F. Miller: Steps in p-aminohippurate transport by kidney slices. Amer. J. Physiol. 196, 86–92 (1959).
Gamble, J.L., K.D. Blackfan, and B. Hamilton: A study of the diuretic action of acid producing salts. J. clin. Invest. 1, 359–388(1925).
Grupp, G., u. K. Hierholzer: Verbrauch von Nierengewebe verschiedener Zonen. Z. Biol. 109, 197–202 (1957).
György, P., W. Keller u. Th. Breme: Nierenstoffwechsel und Nierenentwicklung. Biochem. Z. 200, 356–366 (1928).
Harris, E.J.: Transport and accumulation in biological systems. New York: Academic Press 1956.
Harris, H.: Renal aminoaciduria. Brit. med. Bull. 13, 26–28 (1957).
Hemingway, A., and H.J. Phelps: The carbohydrate metabolism of the kidney. J. Physioli (Lond.) 80, 369–376 (1934).
Herms, W., and R.L. Malvin: Effect of metabolic inhibitors on urine osmolality and electrolyte excretion. Amer. J. Physiol. 204, 1065–1070 (1963).
Hess, R.: Die histochemische Analyse enzymatischer Vorgänge im Nierentubulus. In: Diurese und Diuretica. Hrsg. v. E. Buchborn und K.D. Bock, S. 121–142. Berlin-Göttingen-Heidelberg: Springer 1959.
Hoeber, R.: Physikalische Chemie der Zelle und der Gewebe. 5. Aufl. Leipzig: Wilhelm Engelmann 1922.
Hokin, L.E., and M.R. Hokin: The role of phosphatidic acid and phosphoinositide in transmembrane transport elicited by acetylcholine and other humoral agents. Int. Rev. Neurobiol. 2, 100–137 (1960a).
~ Studies on the carrier function of phosphatidic acid in sodium transport. I. The turnover of phosphatidic acid and phosphoinositide in the avian salt gland on stimulation of secretion. J. gen. Physiol. 44, 61–85 (1960b).
Iacobellis, M., E. Muntwyler, and G. E. Griffin: Enzyme concentration changes in the kidneys of protein- and/or potassium-deficient rats. Amer. J. Physiol. 178, 477–482 (1954).
~ Kidney glutaminase and carbonic anhydrase activity and tissue electrolyte composition in potassium-deficient dogs. Amer. J. Physiol. 183, 395–400 (1955).
Karnovsky, M. J., and S. R. Himmelhoch: Histochemical localization of glutaminase I activity in kidney. Amer. J. Physiol. 201, 786–790 (1961).
Kean, E.L., P.H. Adams, R.W. Winters, and R.E. Davies: Energy metabolism of the renal medulla. Biochim. biophys. Acta (Amst.) 54, 474–478 (1961).
Keilin, D., and T. Mann: On the haematin compound of peroxidase. Proc. roy. Soc. B 122, 119–133 (1937).
Kety, S.S., and C.F. Schmidt: The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J. clin. Invest. 27, 476–483 (1948).
Kisch, B.: Biochemische Unterschiede zwischen Nierenrinde und Nierenmark. Biochem. Z. 277, 210–222 (1935).
Kramer, K., u. P. Deetjen: Beziehungen des O2-Verbrauches der Niere zu Durchblutung und Glomerulusfiltrat bei Änderung des arteriellen Druckes. Pflügers Arch. ges. Physiol. 271, 782–796 (1960).
Kramer, K., K. Thurau u. P. Deetjen: Hämodynamik des Nierenmarks. I. Mitt. Capilläre Passagezeit, Blutvolumen, Durchblutung, Gewebshämatokrit und O2-Verbrauch des Nierenmarks in situ. Pflügers Arch. ges. Physiol. 270, 251–269 (1960).
Krane, S.M., and R. K, Crane: The accumulation of D-galactose against a concentration gradient by slices of rabbit kidney cortex. J. biol. Chem. 234, 211–216 (1959).
Lassen, N. A., O. Munck, and J.H. Thaysen: Oxygen consumption and sodium reabsorption in the kidney. Acta physiol. scand. 51, 371–384 (1961).
Lassen, U.V., and J.H. Thaysen: Correlation between sodium transport and oxygen consumption in isolated renal tissue. Biochim. biophys. Acta (Amst.) 47, 616–618 (1961).
LeFèvre, P.G.: Active transport through animal cell membranes. Wien: Springer 1955.
Levy, M.N.: Influence of variations in blood flow and of dinitrophenol on renal oxygen consumption. Amer. J. Physiol. 169, 937–942 (1959).
Longley, J.B.: Alkaline phosphatase in the kidneys of aglomerular fish. Science 122, 594 (1955).
Lowell, D.J., S.A. Greenspon, C.A. Krakower, and J.A. Bain: Metabolic activity of renal cortical tubular epithelial cells. Amer. J. Physiol. 172, 709–717 (1953).
Lowry, O.H.: The quantitative histochemistry of the brain. Histological sympling. J. Histochem. Cytochem. 1, 420–428 (1953).
Ludwig, C.F.W.: Beiträge zur Lehre vom Mechanismus der Harnsecretion. Marburg: Elwert 1843.
Mattenheimer, H., and H. DeBruin: Glutaminases. An ultramicro method for the determination of glutaminase activity, and a reinvestigation of optimum assay conditions in the kidney of man, dog and rat. Enzymol. biol. clin. 4, 65–83 (1964).
Mattenheimer, H., V.E. Pollak, and H. DeBruin: Quantitative histochemistry of the nephron. IX. Distribution and activity of various enzymes in the kidney of the dog. Enzymol. biol. clin. 4, 107–120 (1964).
McCann, W.P.: Quantitative histochemistry of the dog nephron. Amer. J. Physiol. 185, 372–376 (1956).
Milne, M.D., B.H. Smbner, and M.A. Crawford: Non-ionic diffusion and the excretion of weak acids and bases. Amer. J. Med. 24, 709–729 (1958).
Mudge, G.H.: Clinical patterns of tubular dysfunction. Amer. J. Med. 24, 785–804 (1958).
Nicholson, T.F.: Renal function as affected by experimental unilateral kidney lesions. II. The effect of cyanide. Biochem. J. 45, 112–115 (1949).
Oliver, J.: When is the kidney not a kidney? J. Urol. (Baltimore) 63, 373–402 (1950).
Pitts, R.F.: A comparison of the renal reabsorptive processes for several amino acids. Amer. J. Physiol. 140, 535–547 (1944).
Über aktive Transportmechanismen in den Tubuli der Niere. Klin. Wschr. 33, 365–370 (1955).
Quastel, J.H., and W.R. Wooldridge: Some properties of dehydrogenating enzymes of bacteria. Biochem. J. 22, 689–702 (1928).
Rector, F.C., and J. Orloff: The effect of the administration of sodium bicarbonate and ammonium chloride on the excretion and production of ammonia. The absence of alterations in the activity of renal ammonia producing enzymes in the dog. J. clin. Invest. 38, 366–372 (1959).
Rector, F.C., D.W. Seldin, and J.H. Copenhaver: The mechanism of ammonia excretion during ammonium chloride acidosis. J. clin. Invest. 34, 20–26 (1955).
Rector, F.C., D.W. Seldin, A.D. Roberts, and J.H. Copenhaver: Relation of ammonia excretion to urine pH. Amer. J. Physiol. 179, 353–358 (1954).
Richterich, R.: Enzymopathologie. Enzyme in Klinik und Forschung. Berlin-Göttingen-Heidelberg: Springer 1958.
~ Enzy- matische Vorgänge bei der Harnbereitung: Biochemie. In: Diurese und Diuretica. Hrsg. v. Buchborn und K.D. Bock, S. 91–120. Berlin-Göttingen-Heidelberg: Springer 1959.
~ Physico-chemical factors determining ammonia excretion. Helv. physiol. pharmacol. Acta 20, 326–345 (1962).
Richterich, R., u. H.E. Franz: Das isolierte Glomerulum der Rattenniere. II. Enzymmuster des Energie-Stoffwechsels (C-Raum). Biochem. Z. 334, 149–167 (1961).
Richterich, R., and L. Goldstein: Renal ammonia production as a model for the study of enzyme adaptation in animals. Experientia (Basel) 18, 30–35 (1957).
Richterich, R., P. Schafroth, and H. Aebi: A study of lactic dehydrogenase isoenzyme pattern of human tissues by adsorption-elution on sephadex-DEAE. Clin. chim. Acta 8, 178–192 (1963).
Rosenberg, L.E., S.J. Downing, and S. Segal: Competitive inhibition of dibasic amino acid transport in rat kidney. J. biol. Chem. 237, 2265–2270 (1962).
Rosenberg, T.: The concept and definition of active transport. In: Active transport and secretion. New York: Academic Press 1954.
Ryberg, C.: The importance of sodium ions for the excretion of ammonium and hydrogen ions in the urine. Acta physiol. scand. 15, 161–172 (1948).
Sartorius, O.W., J.C. Roemmelt, and R.F. Pitts: Renal regulation of acid-base balance in man; nature of renal compensations in ammonium chloride acidosis. J. clin. Invest. 28, 423–439 (1949).
Schafroth, P., u. R. Richterich: Das isolierte Glomerulum der Rattenniere. IV. Enzymmuster der Endoxydation. Enzymol. biol. clin. 3, 165–183 (1963).
Schwartz, W. B., A. Falbriard, and A.S. Relman: An analysis of bicarbonate reabsorption during partial inhibition of carbonic anhydrase. J. clin. Invest. 37, 744–751 (1958).
Seevers, M. H., F. E. Shideman, L.A. Woods, J.R. Weeks, and W.T. Kruse: Dehydroacetic acid (DAH). II. General pharmacology and mechanism of action. J. Pharmacol, exp. Ther. 99, 69–83 (1950).
Shannon, J.A.: Renal tubular excretion. Physiol. Rev. 19, 63–93 (1939).
Shideman, F.E., R.C. Rathbun, and F. Stoneman: Inhibition of the renal tubular transport of p-aminohippurate (PAH) and phenolsulfonphthalein (PSP) as affected by acetate. Amer. J. Physiol. 170, 31–37 (1952).
Shideman, F.E., and R.M. Rene: Succinat oxidation and Krebs cycle as an energy source for renal tubular transport mechanisms. Amer. J. Physiol. 166, 104–112 (1951).
Slyke, D.D. van, C.P. Rhoads, A. Hiller, and A.S. Alving: Relationships between urea excretion, renal blood flow, renal oxygen consumption, and diuresis. The mechanism of urea excretion. Amer. J. Physiol. 109, 336–374 (1934).
Smith, H.W.: The kidney, structure in health and disease. New York: Oxford University Press 1951.
~ From fish to philosopher. Boston: Little, Brown 1954.
~ Principles of renal physiology. New York: Oxford University Press 1956.
Taggart, J.Y.: Some biochemical features of tubular transport mechanisms. In: CIBA Foundation Symposium on the kidney. Edit, by A. A. G. Lewis and G.E.W. Wolstenholme, p. 65. London: Churchill 1954.
~ Renal transport of p-aminohippurate labeled with oxygen-18. Science 124, 401–402 (1956).
~ Mechanism of renal tubular transport. Amer. J. Med. 24, 774–784 (1958).
Taggart, J.V., and R.P. Forster: Renal tubular transport: effect of 2, 4-dinitrophenol and related compounds on phenol red j transport in the isolated tubules of the flounder. Amer. J. Physiol. 161, 167–172 (1950).
Taggart, J.V., L. Silverman, and E.M. Trayner: Influence of renal electrolyte composition on the tubular excretion of p-aminohippurate. Amer. J. Physiol. 173, 345–350 (1953).
Terroux, K.G., P. Sekelj, and A.S.V. Burgen: Oxygen consumption and blood flow in the submaxillary gland of the dog. Canad. J. Biochem. 37, 5–15 (1959).
Ullrich, K.J.: Das Nierenmark. Struktur, Stoffwechsel und Funktion. Ergebn. Physiol. 50, 433–489 (1959).
Vries, A. de, S. Kochwa, J. Lazebnik, M. Frank, and M. Djaldetti: Glycinuria, a hereditary disorder associated with nephrolithiasis. Amer. J. Med. 23, 408–415 (1957).
Waldman, R.H., and H.B. Burch: Rapid method for study of enzyme distribution in rat kidney. Amer. J. Physiol. 204, 749–752 (1963).
Weil, L., and J.O. Ely: Investigation in enzymatic histochemistry. I. Distribution of arginase activity in rabbit kidney. J. biol. Chem. 112, 565–577 (1935/36).
Weil, L., and R.K. Jennings: Investigation in enzymatic histochemistry. III. Distribution of enzymes in rabbit kidney. J. biol. Chem. 139, 421–432 (1941).
Wilbrandt, W.: Secretion and transport of non-electrolytes. In- Active transport and secretion. New York: Academic Press 1954.
~ Permeabilität, aktiver Transport und Trägermechanismus. Dtsch. med. Wschr. 82, 1153–1158 (1957).
Wood, F.J.Y.: Ammonium chloride acidosis. Clin. Sci. 14, 81–89 (1955).
Zerahn, K.: Oxygen consumption and active sodium transport in the isolated and short- circuited frog skin. Acta physiol. scand. 36, 300–318 (1956).
~ Oxygen consumption and active sodium transport in isolated amphibian skin under varying experimental conditions. Aarhus: Universitetsforlaget 1958.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1968 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Richterich, R. (1968). Zellstoffwechsel und Enzymologie der Niere. In: Schwiegk, H., et al. Nierenkrankheiten. Handbuch der Inneren Medizin, vol 8 / 0. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95038-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-95038-4_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-95039-1
Online ISBN: 978-3-642-95038-4
eBook Packages: Springer Book Archive