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Nierenkrankheiten pp 1357-1418 | Cite as

Veränderungen des roten Blutbildes bei Nierenkrankheiten

Morphologie, Pathogenese und Therapie
  • H. M. Keller
Part of the Handbuch der Inneren Medizin book series (INNEREN, volume 8 / 0)

Zusammenfassung

Bei weitem im Vordergrund der Blutveränderungen, die wir im Laufe von Nierenerkrankungen beobachten können, steht die Anämie. Schon Bright hat im Jahre 1836 bei der Beschreibung der Klinik der Nierenkrankheiten auf dieses Symptom hingewiesen. In den späteren Darstellungen bis in die jüngste Zeit finden wir die Anämie wohl erwähnt, nach causalen Zusammenhängen wurde aber lange Zeit nicht gesucht.

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Literatur

  1. Abbrecht, P.H., and R.E. Malvin: Renal production of erythropoietin in the dog. Amer. J. Physiol. 210, 2 (1966).Google Scholar
  2. Addis, T., E. Barrett, L.J. Poo, and D.W. Yuen: The relation between the serum urea concentration and the protein consumption of normal individuals. J. clin. Invest. 26, 869 (1947).CrossRefGoogle Scholar
  3. Aebi, H., J.P. Heiniger u. E. Lauber: Met-Hämoglobinbildung in Erythrozyten durch Peroxydeinwirkung. Versuche zur Beurteilung der Schutzfunktion von Katalase und Glutathionperoxydase. Helv. chim. Acta 47, 1428–1440 (1964).CrossRefGoogle Scholar
  4. Allen, D.W., and J.H. Jandl: Oxidative hemolysis and precipitation of hemoglobin II. J. clin. Invest. 40, 454 (1961).PubMedCrossRefGoogle Scholar
  5. Althoff, H.: Zur Bedeutung des Erythropoietins für die klinische Hämatologie. Ärztl. Forsch, 16, I/484 (1962).Google Scholar
  6. Amiel, C.: Le rein, organe erythropoietique ? Presse med. 67 (I), 336 (1959).PubMedGoogle Scholar
  7. Andereggvn, Ph.: Ergebnisse der Sternalpunktion bei nephrogenen Anämien. Helv. med. Acta 13, 3 (1946).Google Scholar
  8. Ardaillou, R.: Anemia in chronic renal insufficiency. Rev. Pract. 12, 2821–2829 (1962).Google Scholar
  9. Ardaillou, R.; Traetement of anemia in renal insufficiency. Vie. med. 44, 1006–1009 (1963).PubMedGoogle Scholar
  10. Ardaillou, R., H. de Montera et G. Riebet: Aspects histologiques de l’autogreffe renale dans le peritoine chez les rats. Rev. franç. Étud. clin. biol. 5, 697–700 (1960).PubMedGoogle Scholar
  11. Ardaillou, R., Y. Najeanet G. Riebet: Étude de l’erythropoiese chez les rats nephrectomises et porteurs d’une autogreffe de rein. Rev. franç. Étud. clin. biol. 5, 189–189 (1960).PubMedGoogle Scholar
  12. Asbe, B.: The hemoglobin percentage and the blood cell count in Brights disease, myocardial insufficiency and hypertension. Arch, intern. Med. 44, 506 (1929).CrossRefGoogle Scholar
  13. Askanazy, S.: Über den Wassergehalt des Blutes und Blutserums bei Kreislaufstörungen, Nephritiden, Anämien und Fieber, nebst Vorbemerkungen über die Untersuchungsmethoden und über den Befund unter physiologischen Verhältnissen. Dtsch. Arch. klin. Med. 59, 385 (1897).Google Scholar
  14. Bangbam, D.R.: Biological assay and a Standard for "Erythropoietin". In: Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  15. Baratb, E.: Über den Hochdruck bei Nebennierenkrankheiten. Wien. klin. Wschr. 56, 295–298 (1943).Google Scholar
  16. Barnard, H.F.: Polycythaemia and renal carcinoma. Brit. med. J. 19611, 1214–1215.Google Scholar
  17. Becker, E.: Studien über Chromogene im Serum und Harn von Nierenkranken und über die Entstehung der hellen Harnfarbe bei Schrumpfnieren. Dtsch. Arch. klin. Med. 148, 46 (1925).Google Scholar
  18. Becker, E.; Vorkommen und Ursachen der Anämie bei Nierenkrankheiten. Münch, med. Wschr. 77 II, 1657 (1930).Google Scholar
  19. Benescb, R.E., and R. Benescb: Relation between erythrocyte integrity and sulfydrylgroups. Arch. Biochem. 48, 38 (1954).CrossRefGoogle Scholar
  20. Berman, L., and E.R. Powsner: Review of methods for studing maturation of human erythroblasts in vitro: evaluation of a new method of culture of cell suspension in a clot-free medium. Blood 14, 1194 (1959).PubMedGoogle Scholar
  21. Beutler, E.: The Glutathione instability of drugsensitive red cells. A new method for the in vitro detection of drug sensitivity. J. Lab. clin. Med. 49, 84 (1957).PubMedGoogle Scholar
  22. Beutler, E., and M.K.Y. Yeb: Erythrocyte glutathione reductase. Blood 21, 573 (1963).PubMedGoogle Scholar
  23. Bilsel, T.C., J.E. Wood, and R.D. Lange: Angiotensin II and ervthropoiesis. Proc. Soc. exp. Biol. (N. Y.) 114, 475 (1963).CrossRefGoogle Scholar
  24. Bircball, R.N., and J.E. Alexander: Medical aspects of pyelonephritis. Medicine (Baltimore) 29, 1–28 (1950).Google Scholar
  25. Bock, H.E.: Die Blutarmut der Nierenkranken. Med. Welt. 1963, Nr 1, 1–12.Google Scholar
  26. Bock, H.E., H. Böttneru. B. Scblegel: Die Lebensdauer übertragener Erythrozyten bei Nierenkranken: Ein Beitrag zur Pathogenese der nephrogenen Anämie. Z. ges. exp. Med. 118, 459–473 (1952).PubMedCrossRefGoogle Scholar
  27. Bock, H.E.,u. W. Gerok: Die freien und gebundenen Aminosäuren im Serum bei Niereninsuffizienz. Dtsch. med. Wschr. 86, 704 (1961).CrossRefGoogle Scholar
  28. Bock, H.E., E.H. Graul, P. Gelinsky, H. Hundesbagen, H. Kuniu. H. Nietb: Radioisotopen-Diagnostik mit Cr51 und Fe59 bei nephrogenen und rheumatischen Anämien. I. Internat. Symposion, Freiburg i. Br. 1962. Stuttgart: F.-K. Schattauer.Google Scholar
  29. Bock, H.E., O.W. Löbru. H. D. Waller: Beitrag zur Pathogenese renaler Anämien. Schweiz, med. Wschr. 92, 1213 (1962).Google Scholar
  30. Bock, H.E., H. Nietbu. K. Soltb: Anämie bei Niereninsuffizienz. Dtsch. med. Wschr. 87, 573–581 (1962).PubMedCrossRefGoogle Scholar
  31. Bock, H.E.,u. F. Tbedering: Über Anämien bei Nierenkrankheiten. 2. Mitt. Dtsch. Arch. klin. Med. 199, 130–150 (1952).Google Scholar
  32. Bock, H.E., H.D. Waller, W. Kaufmannu. G. W. Löbr: Experimenteller Beitrag über die Entstehung renaler Anämien. Dtsch. Arch. klin. Med. 211, 73 (1965).PubMedGoogle Scholar
  33. Bock, H.E.,u. L. Weygand: Über Anämie bei Nierenkrankheiten. 1. Mitt. Die Blutmauserung bei Kranken mit blassem Hochdruck und solchen mit Übergangsformen vom roten zum blassen Hochdruck. Dtsch. Arch. klin. Med. 184, 369–404 (1939).Google Scholar
  34. Böttner, H.,u. B. Scblegel: Innere Krankheiten und Lebensdauer transfundierter Erythrocyten. Verh. dtsch. Ges. inn. Med. 58, 732 (1952).Google Scholar
  35. Boivin, P., et Claude Eocbe-Duval: Une technique simple de dosage de l’erythropoietine chez la souris rendue polycythemique par hypoxic. Rev. franç. fitud. clin. biol. 10, 434 (1965).Google Scholar
  36. Boivin, P.,et G. Lagrue: fitude sur le facteur erythropoietique renal. Nouv. Rev. frang. Hemat. 1, 519–526 (1961).Google Scholar
  37. Borel, Y., R. Busset, R. A. Collet et Nagant de Deuxcbaisnes: Ifitude de la demi-vie des erythrocytes par la methode au chrome-51 dans diverses hemopathies et dans l’insuffisance renale. Schweiz, med. Wschr. 91, 264–270, 296–300 (1961).Google Scholar
  38. Bouissou, H., J. Fabre, J. Familiadeset CI. Regnier: Les nephroanemies. fitude anatomo-pathologique. Rapports avec la maladie de Moschcowitz et la necrose cortocale. Presse med. 71, 233–236 (1963).PubMedGoogle Scholar
  39. Bousser, J., D. Christol, J.C. Gabilanet P. Tcherdakoff: A propos de 4 eas de tumeur renale ou cerebelleuse associe a une Polyglobulie. Vlle Congr. della Soc. Internat, di Ematologia 1958, Roma, p. 122.Google Scholar
  40. Bousser, J., P. Tcherdakoff, J.C. Gabilanet D. Christol: A propos de 4 cas de dumeur renale ou cerebelleuse associe a une polyglobuie. Bull. Soc. med. Hop. Paris 74, 775–782 (1958).PubMedGoogle Scholar
  41. Bright, R.: Reports of medical cases selected with a view illustrating the symptoms and cure of diseases by a reference to morbid anatomy. London: Longman, Rees, Orme, Brown & Green 1827.Google Scholar
  42. Brittinger, Gr.: Zum Problem des Erythropoietins. Blood 6, 230–238 (1960).Google Scholar
  43. Brittinger, Gr.; Neue Ergebnisse der Erythropoieseforschung. Dtsch. med. Wschr. 85, 1346–1348 (1960).PubMedCrossRefGoogle Scholar
  44. Brittinger, G., G. Löffleru. E. König: Angeborene nichtsphärocytäre hämolytische Anämie bei familiärem Mangel an DPNH- und TPNH-abhängiger Glutathionreduktase der Erythrozyten. 1. Mitt. Klin. Wschr. 8, 427 (1965).CrossRefGoogle Scholar
  45. Brown, O.E., and G.M. Roth: The anemia of chronic Nephritis. Arch, intern. Med. 30, 817 (1922).CrossRefGoogle Scholar
  46. Brown, O.E.; Prognostic value of anaemia in chronic glomerular nephritis. J. Amer. med. Ass. 81, 1948 (1923).Google Scholar
  47. Brown, J.R., N. A. Altschuler, and J.A.D. Cooper: Erythropoietic effect of red blood cell components and heme-related compounds. Proc. Soc. exp. Biol. (N.Y.) 112, 840 (1963).CrossRefGoogle Scholar
  48. Brunner, H.E.: Die Differentialdiagnose der Erythrocythaemie durch Untersuchung der Ferro- und Erythrocytenkinetik mit radioaktivem Eisen und Chrom. Klin. Wschr. 8, 429 (1965).CrossRefGoogle Scholar
  49. Büchmann, P.,u. R. Stodtmeister: Toxische Knochenmarksschädigungen bei chronischer Nephritis. Dtsch. Arch. klin. Med. 190, 487–497 (1943).Google Scholar
  50. Bnrke, W.T., and B.S. Morse: Studies on the production and metabolism of erythropoietin in rat liver and kidney. In: Erythropoiesis, p. 111–119. New York: Grune & Stratton 1962.Google Scholar
  51. Callen, LR., and L.R. Limarzi: Blood and bone marrow studies in renal disease. Amer. J. clin. Path. 20, 3 (1950).Google Scholar
  52. Callen, LR., L.R. Limarzi, and H.C. Lueth: Blood and bone marrow findings in renal disease. J. Lab. clin. Med. 32, 1429 (1947).Google Scholar
  53. Cargill, W.H.: The measurement of glomerular and tubular plasma flow in the normal diseased human kidney. J. clin. Invest. 28, 533 (1949).PubMedCrossRefGoogle Scholar
  54. Castleman, B., and B.U. Kibbee: Massachusetts General Hospital: Clinico-pathological exercises, Cas No 45311. New Engl. J. Med. 261, 242 (1959).CrossRefGoogle Scholar
  55. Chaplin Jr., H., and P.L. Molliron: Red cell life span in nephritis and in hepatic cirrhosis. Clin. Sci. 12, 351 (1963).Google Scholar
  56. Chiandnssi, L., B. Higgs, and Shaldon: Studies on iron kinetics and hemoglobin synthesis in the anemia of nephritis, using Fe59. Minerva nucl. 6,371 (1962).Google Scholar
  57. Choremis, C., A. Megas, A. Liaromati and S. Michael: Bone marrow studies in acute-glomerulonephritis. Helv. paediat. Acta 17, 138 (1962).PubMedGoogle Scholar
  58. Clifford, W., Gnrney, and Alter Fried: Further studies on the erythropoietic effect of androgens. J. Lab. clin. Med. 65, 775 (1965).Google Scholar
  59. Cohen, N.N.: Polycythemia associated with bilateral unilocal renal cysts. Arch, intern. Med. 105, 301 (1960).CrossRefGoogle Scholar
  60. Colombi, A.: Differentialdiagnose der chronisch-interstitiellen Nephritis und der primär-chronischen Pyelonephritis. Schweiz, med. Wschr. 91, 1099 (1961).Google Scholar
  61. Cooper, G.W., and M.R. Nocenti: Unilateral renal ischaemia and erythropoietin. Proc. Soc. exp. Biol. (N.Y.) 108, 546–549 (1961).CrossRefGoogle Scholar
  62. Cottier, P.: Gibt es ein Tm für Eisen? (Unveröffentlichte Untersuchungen.)Google Scholar
  63. Damon, A., D. A. Holub, M.M. Meicow, and A.C. Uson: Polycythemia and renal carcinoma. Report of ten new cases, two with long hematologic remission following nephrectomy. Amer. J. Med. 25, 182–197 (1958).PubMedCrossRefGoogle Scholar
  64. Danieli, D., G.P. Masetti, F. Sangiorgi, and L. Pensabeni: Sideroachresti anemia in the course of chronic uremia. J. clin. Med. 45, 855 (1961).Google Scholar
  65. Demopoulos, H.B., B. Highman, P.D. Altland, M. A. Gerving, and G. Kaley: Effects of high altitude on granular juxtaglomerular cells and their possible role in erythropoietin production. Amer. J. Path. 46, 497 (1965).PubMedGoogle Scholar
  66. Desforges, J.F., and J.P. Dawson: The anemia of renal failure. Arch, intern. Med. 101, 326 (1958).CrossRefGoogle Scholar
  67. Dieska, D.: Polyglobulie bei einem Nierentumor. Proc. Vlll. Europ. Congr. Hemat., Bd.1, Nr 271, Wien 1961.Google Scholar
  68. Dittrich, P. v.: Glucose-6-Phosphat-Dehydrogenase in den Erythrozyten bei nephrogenen Anaemien. Klin. Wschr. 40, 1075 (1962).CrossRefGoogle Scholar
  69. Dittrich, P. v.: Karyometrische Untersuchungen an Erythroblasten im Knochenmark von chronischen Nierenkranken. Blut 12,27–31 (1966).CrossRefGoogle Scholar
  70. Dittrich, P. v.,u. H. Sartorius: Knochenmarksuntersuchungen über die Normalisierung der Erythropoiese bei den akuten und chronischen Uraemien durch die Haemodialyse. Klin. Wschr. 38, 543 (1966).CrossRefGoogle Scholar
  71. Doenecke, F.: Über die Veränderung der Blutplättchenzahlen bei akuter diffuser Glomerulonephritis und ihre Bedeutung für die Pathogenese. Z. klin. Med. 121, 121 (1932).Google Scholar
  72. Donati, R.M., R.D. Lange, and N.J. Gallagher: Nephrogenic erythrocytosis. Arch, intern. Med. 112, 960 (1963).Google Scholar
  73. Drivshol, A.: Hypernephroma and polycythaemia. Brit. med. J. 1960 II (2), 1063.CrossRefGoogle Scholar
  74. Dunn, I., I.M. Weinstein, M.H. Maxwell, and C.R. Kleeman: Significance of circulating phenols in anemia of renal disease. Proc. Soc. exp. Biol. (N.Y.) 99, 86 (1958).CrossRefGoogle Scholar
  75. Dyke, D. van, G. Keighley, and J. Lawrence: Decreased responsiveness to erythropoietin in a patient with anemia secondary to chronic uremia. (Abstract.) Blood 22, 838 (1963).Google Scholar
  76. Elder, H.A., and R.A. Mortensen: The incorporation of labeled glycin into erythrocyte glutathione. J. biol. Chem. 218, 261 (1956).PubMedGoogle Scholar
  77. Emerson Jr., C.P., and B.A. Burrows: The mechanism of anemia and its influence on renal function in chronic uremia. J. clin. Invest. 28, 779 (1949); 29, 810 (1950).Google Scholar
  78. Enders, W.,u. L. Friedend: Renale Polycythämie. Dtsch. med. Wschr. 88, 1512–1518 (1963).CrossRefGoogle Scholar
  79. Ensor, R. W.: Renal erythrocytosis. N. Z. med. J. 60, 212 (1961).PubMedGoogle Scholar
  80. Erslev, A.: Humoral regulation of red cell production. Blood 8, 349 (1953).PubMedGoogle Scholar
  81. Erslev, A.; Erythropoietic function in uremic rabbits. Arch, intern. Med. 101, 407 (1958).CrossRefGoogle Scholar
  82. Erslev, A.; Discussion of identity of erythropoietin and its site of production. The kinetics of cellular proliferation, p. 361–363. New York: Grune & Stratton 1959.Google Scholar
  83. Erslev, A.; Erythropoietic factor in the control of red cell production. Ann. N. Y. Acad. Sci. 77, 627 (1959).PubMedCrossRefGoogle Scholar
  84. Erslev, A.; Erythropoietic function in uremic rabbits. II. Effect of nephrectomy on red cell production and iron metabolism. Acta haemat. (Basel) 23, 226 (1960).CrossRefGoogle Scholar
  85. Erslev, A.; Discussion on kinetics of erythropoiesis, p. 195–196. Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  86. Erslev, A.; Disk.-Beitrag „Kolloquium über Erythropoietin". X. Int. Kongr. f. Haematologie, Stockholm 1964.Google Scholar
  87. Fairley, K.D.: Two cases of Gaisböck’s disease (polycythaemia hypertonica) associated with carcinoma of the kidney. Roy. Melb. Hosp. clin. Rep. 16, 47–55 (1945).Google Scholar
  88. Fegler, G: Relationship between reduced glutathione content and spontaneous hemolysis in shed blood. Nature (Lond.) 170, 624 (1952).CrossRefGoogle Scholar
  89. Fischer, J.,u. L. Friederici: Erythropoiese bei bilateral nephrectomierten Kaninchen. Proc. VIII. Europ. Congr. Hemat., p. 283, Wien 1961.Google Scholar
  90. Fischer, J.; Erythropoiese bei bilateral nephrectomierten Kaninchen. Experientia (Basel) 17, 318–319 (1961).CrossRefGoogle Scholar
  91. Fisher, G., G. Taylor, and P.D. Porteous: Localization of erythropoietin in glomeruli of sheep kidney by fluorescent antibody technique. Nature (Lond.) 205, 611 (1965).CrossRefGoogle Scholar
  92. Fisher, J.W., and B.J. Birdwell: Erythropoietin production by the situ perfused kidney. Fed. Proc. 20, 68 (1961).Google Scholar
  93. Fisher, J.W.; The production of an erythropoietic factor by the in situ perfused kidney. Acta haemat. (Basel) 26, 224 (1961).CrossRefGoogle Scholar
  94. Fisher, J.W., and J.J. Crooli: Influence of several hormones on erythropoiesis and oxygen consumption in the hypophysectomized rat. Blood 19, 557 (1962).PubMedGoogle Scholar
  95. Fisher, J.W., M.P. Sanzari, B.J. Birdwell, and J.J. Crook: The role of the kidney in erythropoietin production. In: Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  96. Frey, J.: Die Nierensekretion. In: Lehrbuch der speziellen pathologischen Physiologie, hrsg. V. L. Heilmeyer. Stuttgart: Gustav Fischer 1960.Google Scholar
  97. Frey, J.: Krankheiten der Niere. In: Lehrbuch der inneren Medizin, hrsg. v. L. Heilmeyer. Berlin-Göttingen-Heidelberg: Springer 1961.Google Scholar
  98. Frick, P. G.,u. H. E. Brunner: Renale Polycythämie. Ferrokinetische Untersuchungen mit Fe59. Proc. VIII. Europ. Congr. Hemat. Bd. I, Nr 270, Wien 1961.Google Scholar
  99. Frick, P. G.; Renale Polycythaemie. Eisenstoffwechseluntersuchungen mit Fe59. Schweiz, med. Wschr. 92, 288 (1962).Google Scholar
  100. Frick, P. G.; Isotopendiagnostik in der Hämatologie. Helv. med. Acta 31, 345–359 (1964).PubMedGoogle Scholar
  101. Fried, D. G., R.G. Hoskins, and M.W. Kirkin: Relative erythrocythemia (polycythemia) and polycystic kidney disease with uremia. Report of a case, with comment on frequency of occurence. New Engl. J. Med. 264, No. 1 17–19 (1961).CrossRefGoogle Scholar
  102. Gallagher, N.L, and R.D. Lange: Response to erythropoietin. Proc. Soc. exp. Biol. (N.Y.) 110, 422 (1962).CrossRefGoogle Scholar
  103. Gallagher, N.L, J. McCarthy, K. T. Hart, and R.D. Lange: Evaluation of plasma erythropoietic-stimulating factore in anemic uremic patients. Blood 14, 662 (1959).PubMedGoogle Scholar
  104. Gallagher, N.L, J.M. McCarthy, and R.D. Lange: Erythropoietic stimulating factor (ESF) production in nephrectomized rabbits. Fed. Proc. 19, 68 (1960).Google Scholar
  105. Gallagher, N.L.; Observations on erythropoietic-stimulating factor (ESF) in the plasma of uremic and nonuremic anemic patients. Ann. intern. Med. 52, 1201 (1960).PubMedCrossRefGoogle Scholar
  106. Gallagher, N.L.; Erythropoietin production in uremic rabbits. J. Lab. clin. Med. 57, 281 (1961).PubMedGoogle Scholar
  107. Garcia, J.F., and B.C. van Dyke: Dose-response relationship of human urinary erythropoietin. J. appl. Physiol. 14, 233–236 (1959).PubMedGoogle Scholar
  108. Garcia, J.F.: and J.C. Schooley: An immunological study of human urinary erythropoietin. Erythropoiesis, p. 56–57. New York: Grune & Stratton 1962.Google Scholar
  109. Gardner, F.H.: The use of cobaltous chloride in the anemia associated with chronic renal diasease. J. Lab. clin. Med. 41, 56 (1953).PubMedGoogle Scholar
  110. Gardner, F.H., and J.G. Freymann: Erythrocythemia (polycythemic) and hydronephrosis. New Engl. J. Med. 259, 323 (1958).PubMedCrossRefGoogle Scholar
  111. Gehrman, G.,u. W. Schmitz: Beitrag zur „renalen Polyzythämie". Dtsch. med. Wschr. 87, 1798–1800 (1962).CrossRefGoogle Scholar
  112. Gewirtz, N.R., L.R. Wasserman, L. Sharney, and D. Tendier: Studies of plasma Fe59 disappearance. A manifestation of ineffective erythropoiesis and of hemolysis. Blood 15, 976 (1965).Google Scholar
  113. Giovannett, S., M. della Santa, and A. Bigalli: The hemolytic component in the pathogenesis of acute uremic anemia, experimental study. Minerva nephrol. 10, 226–228 (1963).Google Scholar
  114. Goldfarb, B., and L. Tobian: The interrelationship of hypoxia, erythropoietin and the renal juxtaglomerular cell. Proc. Soc. exp. Biol. (N.Y.) Ill, 510 (1962).Google Scholar
  115. Goldring, W., and H. Chasis: Hypertension and hypertensive disease. New York: Commonwealth Fund 1944.Google Scholar
  116. Goldwasser, E., W. Fried, and L. G. Jacobsen: Studies on erythropoiesis. VIII. The effect of nephrectomy on response to hypoxic anoxia. J. Lab. clin. Med. 52, 375 (1958).PubMedGoogle Scholar
  117. Gordon, A.S.: Discussion on relationship to anemia, polycythemia and renal abnormalities. In: Erythropoiesis, p. 387. New York: Grune & Stratton 1962.Google Scholar
  118. Gordon, A.S., B.S. Dornfest, C.D. Siegel, and N. Gottlieb: Hemopoiesis in isolated perfused hind limbs of hypophysectomized rats. Fed. Proc. 17, 57 (1958).Google Scholar
  119. Gordon, A. S., J. LoBue, B. S. Dornfest, and G. W. Cooper: Conference on erythropoietin and regulation of erythropoiesis. San Francisco, Jan. 1962.Google Scholar
  120. Gordon, A.S., S.J. Piliero, W. Kleinberg, and H.H. Freedman: A plasma extract with erythropoietic activitv. Proc. Soc. exp. Biol. (N.Y.) 86, 255 (1954).CrossRefGoogle Scholar
  121. Gordon, A.S., J.W. Winkert, B.S. Dornfest, J. LoBue, and A. Crusco: Properties of the urinary erythropoietic-stimulating factor (ESF), the kinetics of cellular proliferation, p. 332–343. New York: Grune & Stratton 1962.Google Scholar
  122. Gordon, A.S., J. Winkert, B.S. Dornfest, and S.D. Siegel: Studies on the actions and properties of the circulating erythropoietic stimulating factor. Ann. N.Y. Acad. Sci. 77, 650 (1959).PubMedCrossRefGoogle Scholar
  123. Graham, L.A., R.J. Winzler, and H.E. Charles: Separation and partial characterization of Erythropoietin from human urine. Endocrinology 73, 475 (1963).PubMedCrossRefGoogle Scholar
  124. Grollmann, A.: Effect of increasing the extracellular fluid volume on the arterial blood pressure of the normal, hypertensive and nephrectomized dog. Amer. J. Physiol. 173, 364 (1953).Google Scholar
  125. Grollmann, E.F., and A. Grollmann: Toxicity of urea and its role in the pathogenesis of uremia. J. clin. Invest. 38, 749 (1959).CrossRefGoogle Scholar
  126. Gros, H.: Hypernephrom und Polyglobulie. Medizinische 19, 706–708 (1955).PubMedGoogle Scholar
  127. Gurney, C.W.: Erythropoietin, erythropoiesis and the kidney. J. Amer. med. Ass. 173, 1828–1829 (1960).CrossRefGoogle Scholar
  128. Gurney, C.W.; Relationship of erythropoietin production to renal abnormalities. Erythropoiesis, p. 359–360. New York: Grune & Stratton 1962.Google Scholar
  129. Gurney, C.W., R.Degowin, D. Hofstra, and J. Byron: Application of erythropoietin to biological investigation. In: Erythropoiesis, p. 151. New York: Grune & Stratton 1962.Google Scholar
  130. Hadnagy, C. S., F. Gyergyayu. Z. Antal: Beitrag zur Anaemie der Nierenkranken: Mitosenhäufigkeit in Dünndarm- und Zungenepithel nach Nephrectomie. Klin. Wschr. 4, 241 (1965).CrossRefGoogle Scholar
  131. Hänze, S.,u. W. Hiller: Serum- und Erythrocyten-Magnesium bei renaler Insuffizienz. Klin. Wschr. 41, 1055 (1963).CrossRefGoogle Scholar
  132. Hammond, G.D., and A. Ishikawa: The rate of disappearance of erythropoietin in following transfusion of several anemic patients. In: Erythropoiesis, p. 128. New York: Grune & Stratton 1962.Google Scholar
  133. Hegglin, R.: Anämien. In: Differentialdiagnose innerer Krankheiten. Stuttgart: Georg Thieme 1963.Google Scholar
  134. Heilmeyer, L.: Blutstoffwechselstudien. IV. Mitt. Die Blutstoffregulation bei der akuten und chronischen Blutungsanämie, sowie bei einigen sekundären Anämien anderer Genese. Dtsch. Arch. klin. Med. 172, 341 (1932).Google Scholar
  135. Heilmeyer, L.; Zur spektralen Analyse der normalen Serumfarbe. Klin. Wschr. 10, 1349 (1932).CrossRefGoogle Scholar
  136. Heilmeyer, L., H. Merker, H.P. Wetzel, D. Klemm, P. Burmeisteru. R. Haas: Atransferrinämie bei nephrotischem Syndrom mit besonderer Berücksichtigung des Eisen- und Eiweißstoffwechsels. Dtsch. med. Wschr. 90, 1649–1656 (1965).PubMedCrossRefGoogle Scholar
  137. Heinrich, H.C.,u. E. E. Gabbe: Intestinale Resorbierbarkeit und Vitamin B12-antagonistische Wirkung eines hochwirksamen Big-Antivitamins aus der Reihe der Alkanolamin-Analoga des Vitamin B12 beim Menschen. Klin. Wschr. 4, 196 (1965).CrossRefGoogle Scholar
  138. Henkin, R.E., P.H. Byatt, and M.H. Maxwell: Evidence for the presence of a dialyzable "toxic" factor in the sera of uremic patients. Clin. Res. 9, 202 (1961).Google Scholar
  139. Hewlett, J.S., G.C. Hoffman, D.A. Sennhauser, and J.D. Battle Jr.: Hypernephroma with erythrocythemia. Report of a case and assay of the tumor for an erythropoietic-stimulating substance. New Engl. J. Med. 262,1058–1062 (1960).PubMedCrossRefGoogle Scholar
  140. Hirashima, K., and F. Takaku: Experimental studies on erythropoietin. II. The relationship between juxtaglomerular cells and erythropoietin. Blood 20, 1–8(1962).Google Scholar
  141. Hodgson, G. and J. Toha: The erythropoietic effect of urine and plasma of repeatedly bled rabbits. Blood 9, 299 (1954).PubMedGoogle Scholar
  142. Hopper Jr., J., B.G. Anderson, and M.E. Dailey: Cobaltous chloride in the treatment of anemia associated with renal insufficiency and its effect on thyroid function. Amer. J. med. Sci. 238, 66–72 (1959).PubMedCrossRefGoogle Scholar
  143. Huggins, C., D.F. Tapley, and E.V. Jensen: Sulphydryl-disulphide relationship in the induction of gels in proteins by urea. Nature (Lond.) 167, 592 (1951).CrossRefGoogle Scholar
  144. Hurtado, A., C. Merino, and E. Delgado: Influence of anoxemia on hemopoietic activity. Arch, intern. Med. 75, 284 (1945).CrossRefGoogle Scholar
  145. Jacobson, L. O., E. Goldwasser, C.W. Curney, W. Fried, and L. Plzak: Studies of erythropoietin. The hormone regulating red cell production. Ann. N. Y. Acad. Sci. 77, 551 (1959).PubMedCrossRefGoogle Scholar
  146. Jacobson, L. O., E. Goldwasser, W. Fried, and L. Plzak: Role of the kidney in erythropoiesis. Nature (Lond.) 179, 633–634 (1957).CrossRefGoogle Scholar
  147. Jacobson, L.O., E. Goldwasser, and C.W. Gurney: Control of red cell formation. The kinetics of cellular proliferation, p. 344–356. New York: Grune & Stratton 1959.Google Scholar
  148. Jacobson, L.O., E.K. Marks, E.O. Gaston, and E. Goldwasser: Studies on erythropoiesis. XI. Reticulocyte response of transfusion induced polycythemic mice to anemic plasma from nephrectomized mice and to plasma from nephrectomized rats exposed to low oxygen. Blood 14, 635 (1959).PubMedGoogle Scholar
  149. Jahrmärker, H.: Über den Adeninnucleotidgehalt der Erythrocyten bei Niereninsuffizienz. Klin. Wschr. 42, 123 (1964).CrossRefGoogle Scholar
  150. Javorkovskij, L.I.: Die hämolytische Anämie bei chronischer Pyelonephritis (zur Pathogenese der nephrogenen Anämien). Ter. Arkh. 34, 28–34 (1962).Google Scholar
  151. Jocelyn, P.C.: Glutathione metabolism in animals. Biochem. Soc. Symo. No 17, Cambridge 1959, p. 43.Google Scholar
  152. Jocelyn, P.C.; The effect of vitamin B12 on the reduction of glutathione disulfide in human erythrocytes. Biochem. J. 72, 11 (1959).Google Scholar
  153. Jones, N.F., and M.B. Cantab: Renal polycythaemia. Lancet 1960 I, 299.CrossRefGoogle Scholar
  154. Jones, N.F., R.W. Payne, R.D. Hyde, and T.M.L. Price: Renal polycythaemia. Lancet 1960 I (60), 299–303.CrossRefGoogle Scholar
  155. Joske, R. A., J.M. McAllster, and T. A. J. Prankard: Isotope investigations of red cell production and destruction in chronic renal disease. Clin. Sci. 15, 511–522 (1956).PubMedGoogle Scholar
  156. Kaley, G., and H.B. Demopoulous: Effect of erythropoietic stimuli on renin content and juxtaglomerular cells. Fed. Proc. 22, 664 (1963).Google Scholar
  157. Kan, Y.W., A. J.S. McFadzean, D. Todd, and S.C. Tso: Further observations on polycythemia in hepatocellular carcinoma. Blood 18, 592 (1961).PubMedGoogle Scholar
  158. Kasanen, A.: The effect of anabolic steroid, durabolin, on renal anemia. Ann. Med. intern. Fenn. 52, 263–265 (1963).PubMedGoogle Scholar
  159. Kasanen, A., and J. Forstrom: The effect of simultaneous intramuscular ascorbic acid and cobalttherapy of renal anemia. Ann. Med. exp. Fenn. 41, 103–105 (1963).PubMedGoogle Scholar
  160. Kasanen, A., R. Heikinheimo, and J. Forstrom: Haemostatic defect and anemia in uremic patients with and without abuse of phenacetin. Ann. med. intern. Fenn. 52,97–100 (1963).PubMedGoogle Scholar
  161. Kasanen, A., M. Kulonen, and Eskolisalo: Effect of intramuscular cobalt an the anemia of patients with pyelonephritis. Acta med. scand. 171, 379–383 (1962).PubMedCrossRefGoogle Scholar
  162. Kasanen, A., M. Kulonen, and J. Forstrom: Oral cobalt therapy in renal anemia. Ann. Med. intern. Fenn. 52, 43–48 (1963).PubMedGoogle Scholar
  163. Kasbekar, D.K., and A. Sreenivasan: Biosynthesis of glutathione by rat erythrocytes. J. Biochem. 72, 389 (1959).Google Scholar
  164. Kaye, M.: The anemia associated with renal disease. J. Lab. clin. Med. 52, 83 (1958).PubMedGoogle Scholar
  165. Keighlei, G.: Experiences with assays, units and standards of erythropoietin. In: Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  166. Keller, H.M.: Haemopoietine und Knochenmarksbefunde bei der Anaemie infolge akuter und chronischer Urämie. Vlle Congr. della Soc. Internat. Ematologia Roma, 1958, S. 203.Google Scholar
  167. Keller, H.M.; Die Bedeutung der Niere in der Regulation der Erythropoiese. In: Aktuelle Probleme der Haemodialyse und der chronischen Niereninsuffizienz, S. 151. München-Berlin-Wien: Urban & Schwarzenberg 1966.Google Scholar
  168. Keller, H.M.; Renale Anämien. Fortb.kuis f. inn. Med. Fribourg 1963. (Nicht veröffentl.).Google Scholar
  169. Keller, H.M.; Eisenbindungskapazität des Serums bei Nierenerkrankungen. (Noch unveröffentl.)Google Scholar
  170. Keller, H.M., H. Cottieru. F. Beubi: Fehlen von Nieren Veränderungen nach Colibazilleninjektionen bei mit Phenacetin chronisch behandelten Kaninchen. Schweiz, med. Wschr. 91, 1021 (1961).Google Scholar
  171. Keller, H.M.,u. K. Khalifa: Untersuchungen über Erythropoietin bei nephrectomierten Ratten. Acta haemat. (Basel) 29, 336 (1963).CrossRefGoogle Scholar
  172. Keller, H.M., K. Khalifaet F. Reubi: La signification des hemopoietines pour le developpement des anemies observees au cours de nephropathies. 1. Congr. int. Nephr. Geneve/Evian 1960, p. 550–558.Google Scholar
  173. Keller, H.M.,u. G. Locher: Untersuchungen der Ferrokinetik und des Knochenmarkes bei doppelseitig nephrektomierten Kaninchen. (Noch unveröffentl.)Google Scholar
  174. Kleeman, C.R., W.L. Hewitt, and L.B. Guze: Pyelonephritis. Medicine (Baltimore) 39, 3 (1960).Google Scholar
  175. Kollert, V.,u. K. Faschkis: Das weiße Blutbild bei Nephritis. Z. klin. Med. 112, 275 (1930).Google Scholar
  176. Korst, D.R., E.P. Frenkel, L. Cousineau, and E.E. Muirhead: Erythropoietin studies in human renal abnormalities. Correlative renal explant attempts in the rat and dog. In: Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  177. Korst, D. R., B. E. Whalley, and F. H. Bethell: Erythropoietic activity of plasma in polycythemia. J. Lab. clin. Med. 54, 916 (1959).Google Scholar
  178. Koy, A.: Biosynthesis of glutathione in human blood cells. Acta biochim. pol. 9 (1962). Ref. in Blood 20, 254 (1962).Google Scholar
  179. Kruh, J., and H. Borsook: Hemoglobin synthesis in rabbit reticulocytes in vitro. J. biol. Chem. 220, 905 (1956).Google Scholar
  180. Kuratowska, Z.: Symposion über Erythropoietin. X. Int. Kongr. f. Hämatologie, Stockholm, 1964.Google Scholar
  181. Kuratowska, Z., and B. Lewartowski: Studies on the active principle released by the hypoxic kidney into Tyrode’s solution. In: Erythropoiesis. New York: Grune & Stratton, 1962Google Scholar
  182. Kuratowska, Z., B. Lewartowski, and E. Michalak: Studies on the production of erythropoietin by isolated perfused organs. Blood 18, 527 (1961).PubMedGoogle Scholar
  183. Kuratowska, Z.; Studies on the production of erythropoietin by the isolated hypoxic kidney. Bull. Acad. pol. Sci., Ser. Biol. 8, 77 (1960).Google Scholar
  184. Zit. in: T.A. Waldmann and W.F. Rosse, Sites of formation of erythropoietin. In: Erythropoiesis. New York: Grune & Stratton 1962.Google Scholar
  185. Kurtides, E.S., A.W. Rambach, H.L. Alt, and F. Del Greco: Effect of hemodialysis on erythrokinetics in anemia of uremia. J. Lab. clin. Med. 3, 469 (1964).Google Scholar
  186. Komiya, E.: Weitere Beiträge über die neurohumoral Regulation des Blutbildes. Folia haemat. (Frankfurt), N.F. 3, 46–57 (1958).Google Scholar
  187. Lange, R.D., and N.I. Gallagher: Clinical and experimental observations on the relationship of the kidney to erythropoietin production. In: Erythropoiesis, p. 361–373. New York: Grune & Stratton 1962.Google Scholar
  188. Larsen, O.A., P. Josephsen, and N.A. Larsen: Nephrogenous anemia treated with erythropoietin. Ugeskr. Laeg. 125, 435–438 (1963).Google Scholar
  189. Lawrence, J. H., and W. G. Donald: Polycythemia and hydronephrosis on renal tumors. Ann. intern. Med.50, 959 (1959).PubMedCrossRefGoogle Scholar
  190. Lewis, J.H., M.B. Zucker, and J.H. Ferguson: Bleeding tendency in uremia. Blood 11, 1073 (1956).PubMedGoogle Scholar
  191. Linman, J. W., and F.H. Bethell: Factors controlling erythropoiesis. Springfield (Ill.): Ch. C. Thomas 1960.Google Scholar
  192. Löhr, G.W.: Glucosestoffwechsel der roten Blutzellen. Scand. J. hemat. 10,1 (1965).Google Scholar
  193. Löhr, G. W., P. Baum,u. G. Kamm: Toxische hämolytische Anämien. Med. Klin. 58, 2111 (1963).Google Scholar
  194. Löhr, G.W.,u. H. D. Waller: Zellstoffwechsel und Alterung. Klin. Wschr. 37, 833 (1959).CrossRefGoogle Scholar
  195. Löhr, G.W.; Biochemie und Pathogenese der enzymopenischen hämolytischen Anämien. Dtsch. med. Wschr. 86, 27, 87 (1961).CrossRefGoogle Scholar
  196. Löhr, G.W.; Zur Biochemie der Erythrocytenalterung. Foha haemat. (Lpz.) 78, 117 (1962).Google Scholar
  197. Lohr, G.W., H.D. Waller, O. Karges, B. Schlegelu. A. A. Müller: Zur Biochemie der Alterung menschlicher Erythrozyten. Klin. Wschr. 36, 1008 (1958).PubMedCrossRefGoogle Scholar
  198. Loge, J.P., R.D. Lange, and C.V. Moore: Characterization of the anemia of chronic renal insufficiency. J. clin. Invest. 29, 830 (1950).PubMedGoogle Scholar
  199. Loge, J.P.; Characterization of the anemia associated with chronic renal insufficiency. Amer. J. Med. 24, 4 (1958).PubMedCrossRefGoogle Scholar
  200. London, I.M., and H. Schwarz: Erythrocyte metabolism. The metabolic behaviour of the cholesterol of human erythrocytes. J. clin. Invest. 32, 1248 (1953).PubMedCrossRefGoogle Scholar
  201. London, I.M., D. Shemin, and D. Rittenberg: Synthesis of heme in vitro by the immature non-nucleated mammalian erythrocyte. J. biol. Chem. 183, 748 (1950).Google Scholar
  202. Lorenzen, J., and H. Worning: Eenal papillary necrosis, haemolytic anemia and misuse of phenacetin. Nord. Med. 68, 1138–1139 (1962).Google Scholar
  203. Lowy, P.H., G. Keighley, H. Borsook, and A. Gaybiel: Isolation of an erythropoietic fraction from the plasma of rabbits made severely anaemic with Phenylhydrazine. Nature (Lond.) 181, 1802 (1958).CrossRefGoogle Scholar
  204. Lutzeyer, W.,u. H. H. Teihmann: Nierentumor und Polycythaemie. Ärztl. Wschr. 15, 253–257 (1960).Google Scholar
  205. Manesen, N., J. Avram, A. Meth, R. Henring, and S. Pop: Nephrogenic anemia. Clinical and etiopathogenetic considerations. Med. Intern. (Bueur) 14, 1109–1116 (1962).Google Scholar
  206. Markson, J.L., and J.B. Rennie: Anemia of chronic renal insufficiency; effect of serum from azotemic patients on maturation of normoblasts in suspension cultures. Scot. med. J. 1, 320 (1956).PubMedGoogle Scholar
  207. Martt, J.M., A. Sayman, and M.-P. Neal: Polycythemia and hydronephrosis. Ann. intern. Med. 54, 790 (1961).PubMedCrossRefGoogle Scholar
  208. Mathieson, A.R., and M.R. Porter: The effect of urea on the streaming by refringence and viscosity of sodium deoxyribonucleate. J. chem. Soc. 1958, 1298.Google Scholar
  209. Matthews, D.M., and A. Gordon Beckett: Serum vitamin B12 in renal failure. From Royal Free Hospital, London. J. clin. Path. 15, 456–458 (1962).CrossRefGoogle Scholar
  210. Medici, P.T., J.M. Hurst, and S.J. Piliero: Protective effects of erythropoietin against Myleran induced hematopression. Acta haemat. (Basel) 33, 167 (1965).CrossRefGoogle Scholar
  211. Medwei, C.V.: Über ein bemerkenswertes Zusammentreffen von Arthritis urica, Erythraemie Typ Vaquez und Hypernephroma malignum. Wien. Arch, inn. Med. 24, 417–426 (1934).Google Scholar
  212. Mertz, D.P.,u. R. Koschnik: Nephrogene Anaemien und Nierendynamik. Schweiz, med. Wschr. 95, 83–91 (1965).Google Scholar
  213. Miller, A., and M. Horiuchi: Erythrocyte glutathione. I. In vitro incorporation of radio-active amino acids presursors into the glutathione of human erythrocytes. J. Lab. clin. Med. 60, 756 (1962).Google Scholar
  214. Mirand, E.A.: Discussion of identity of erythropoietin and its site of production. The kinetics of cellular proliferation, p. 363. New York: Grune & Stratton 1959.Google Scholar
  215. Mirand, E. A., and T.C. Prentice: Presence of plasma erythropoietin in hypoxic rats with or without kidney(s) and/or spleen. Proc. Soc. exp. Biol. (N.Y.) 96, 49 (1957).CrossRefGoogle Scholar
  216. Mitus, W.J., and K. Toyama: Experimental renal erythrocytosis. Arch. Path. 78, 658 (1964).PubMedGoogle Scholar
  217. Morgan, J.M., and R.E. Morgan: Study of the effect of the uremic metabolites on erythrocyte glycolysis. Metabolism 13, 629 (1964).PubMedCrossRefGoogle Scholar
  218. Morgan, J.M., R.E. Morgan, and G.E. Thomas: Inhibition of lactic dehydrogenase by ultrafiltrate of uremic blood. Metabolism 12, 1051 (1963).PubMedGoogle Scholar
  219. Muirhead, E.E., and F. Jones: Renoprival hemolysis and its prevantion by renal tissue. Blood 22, 272 (1963).PubMedGoogle Scholar
  220. Muirhead, E.E., F. Jones, and A. Grollman: The anemia of renal insufficiency as induced by bilateral nephrectomy of the rabbit: with emphasis on its hemolytic nature. J. Lab. clin. Med. 39, 505 (1962).Google Scholar
  221. Muirhead, E.E., F. Jones, J. A. Stirman, and W. Leache: Hemolytic anemia of the dog following bilateral nephrectomy. Amer. J. Physiol. 173, 371 (1953).PubMedGoogle Scholar
  222. Muirhead, E.E., M. Kosinski, F. Jones, and E. Reno: Renal autoexplantation and the site of origin erythropoietin from the kidney. J. Lab. clin. Med. 60, 1001 (1962).Google Scholar
  223. Naets, J.P.: Erythropoiesis in nephrectomized dogs. Nature (Lond.) 181, 1034 (1958).CrossRefGoogle Scholar
  224. Naets, J.P.; The kidney and erythropoiesis. Nature (Lond.) 182,1516 (1958).CrossRefGoogle Scholar
  225. Naets, J.P.; Erythropoiesis in nephrectomized dogs. Experientia (Basel) 14, 74(1958).Google Scholar
  226. Naets, J.P.; Erythropoietic activity in plasma and urine of dogs after bleeding. Proc. Soc. exp. Biol. (N.Y.) 102, 387 (1959).CrossRefGoogle Scholar
  227. Naets, J.P.; Disappearance of the erythropoietic factor from plasma of anemic dogs after nephrectomy. Nature (Lond.) 184, 371 (1959).CrossRefGoogle Scholar
  228. Naets, J.P.; Erythropoietic factor in kidney tissue of anemic dogs. Proc. Soc. exp. Biol. (N.Y.) 103, 129 (1960).CrossRefGoogle Scholar
  229. Naets, J.P.; The role of the kidney in erythropoiesis. J. clin. Invest. 39, 102 (1960)PubMedCrossRefGoogle Scholar
  230. Naets, J.P.; The role of the kidney in the production of the erythropoietic factor. Blood 16, 1770 (1960).PubMedGoogle Scholar
  231. Naets, J.P.; Role du rein dans I’erythropoiese. C. R. 1. Congr. int. Nephrol. Geneve/Evian, 1960, p. 547–549, 1961.Google Scholar
  232. Naets, J. P., H. Braumanet M. Kraytman: Etude de I’erythropoiese au cours de I’insuffisance renale aigueet chronique. Acta haemat. (Basel). 24,169 (1960).CrossRefGoogle Scholar
  233. Naets, J. P., and A.F. Heuse: Measurement of erythropoietic stimulating factor in anemic patients with or without renal disease. J. Lab. clin. Med. 60,365 (1962).PubMedGoogle Scholar
  234. Naets, J. P.; Effect of anemic hypoxia on uremic dogs with and without kidneys. In: Erythropoiesis, p. 98–100. New York: Grune & Stratton 1962.Google Scholar
  235. Najean, Y., N. Ardaillon, C. Dreschet M. Tubiana: Technique d’etude de I’erythropoiese a I’aide du fer radio-activ. Rev. franç. fitud. clin. biol. 10, 321 (1965).Google Scholar
  236. Nakao, M., T. Nakao, S. Yamazoes, and H. Toshikawa: Adenosine triphosphate and shape of erythrocytes. J. Biochem. 49, 487 (1961).PubMedGoogle Scholar
  237. Nathan, D.G., and N.L Berlin: Studies of the production and life span of erythrocytes in myeloid metaplasia. Blood 14, 668 (1958).Google Scholar
  238. Nathan, D.G., E. Schupak, F. Stohlman Jr., and J.-P. Merrill: Erythropoiesis in anephric man. J. clin. Invest. 43, 2158 (1964).PubMedCrossRefGoogle Scholar
  239. Nelp, W.B., H.N. Wagner Jr., and R.C. Reba: Renal excretion of vitamin B12 and its use in measurement of glomerular filtration rate in man. J. Lab. clin. Med. 3, 480 (1964).Google Scholar
  240. Nixon, R.K., W. O’Rouke, C.E. Rupe, and D.R. Korst: Nephrogenic polycythemia. Arch, intern. Med. 106, 797 (1960).CrossRefGoogle Scholar
  241. Nordenson, N.G.: The bone marrow in the anemia of chronic nephritis. Folia haemat. (Lpz.) 59, 1 (1958).Google Scholar
  242. Nordenson, N.G.; Kobalt-, Kupfer- und Eisenbehandlung chronischer Anaemien. Schweiz, med. Wschr. 91, 927–931Google Scholar
  243. Nylander, G.: Beiträge zur Kenntnis der Anämie bei diffusen Nierenerkrankungen. Acta med. scand. Suppl. 59, 85, 1 (1935).Google Scholar
  244. Omland, Gr.: Polycythemia in renal carcinoma. Acta med. scand. 164, 451–454 (1959).PubMedCrossRefGoogle Scholar
  245. Ophüls, W.: Nephritis and its relation to cardiovascular disease. J. Amer. med. Ass. 98, 731 (1931).CrossRefGoogle Scholar
  246. Orten, J.M., and M.C. Bucciero: Effect of cysteine, histidine and methionine on production of polycythemia by cobalt. J. biol. Chem. 176, 961 (1948).PubMedGoogle Scholar
  247. Osnes, S.: A erythropoietic factor produced in the kidney. Brit. med. J. 1958 II, 1387.CrossRefGoogle Scholar
  248. Osnes, S.; Experimental study of an erythropoietic principle produced in the kidney. Brit. med. J. 1959 II., 650.CrossRefGoogle Scholar
  249. Page, L.B, and P.J. Culver: A syllabus of laboratory examination in clinical diagnosis. Cambridge: Harvard University Press 1960.Google Scholar
  250. Pakodzy, K.: Über den Zusammenhang zwischen den Nierenkrankheiten und den haemorrhagischen Diathesen. Z. klin. Med. 112, 124 (1930).Google Scholar
  251. Pavlovic-Kentera, V., D.P. Hall, C. Brapssa, and R.D. Lange: Unilateral renal hypoxia and production of Erythropoietin. J. Lab. clin. Med. 4, 577 (1965).Google Scholar
  252. Payne, R. W., and N.P. Jones: Role of the erythropoietic hormone. Lancet 1961 I (61), 510–511.CrossRefGoogle Scholar
  253. Payne, E.W., N.P. Jones, and R.D. Hyde: Renal erythraemia. Proc. VIII Europ. Congr. Hemat. Wien 1961, Bd. I, S. 269.Google Scholar
  254. Penington, D.O.: The role of the erythropoietic hormone in anemia. Lancet 1961 I (61), 301–306.CrossRefGoogle Scholar
  255. Penington, D.O.; Role of the erythropoietic hormone. Lancet 1961 I (61), 776–777.CrossRefGoogle Scholar
  256. Penington, D.O.; Discussion on relationship to anemia, polycythemia and renal abnormalities. In: Erythropoiesis, p. 386. New York: Grune & Stratton 1962.Google Scholar
  257. Penington, D.O.; Discussion on sites of formation. In: Erythropoiesis, p. 102. New York: Grune & Stratton 1962.Google Scholar
  258. Pense, G., H. Fiehring, G. Panzramu. B. Lorenz: Nil nocere!: Ursachen und Folgen des Phenazetinmißbrauches bei 11 Patienten. Münch, med. Wschr. 102, 683–687 (1960).Google Scholar
  259. Piliego, N.: Current pathogenetic concepts on the anemia of chronic renal insufficiency. Study of the behavior of the plasma erythropoietin in 28 cases of chronic kidney disease. Rass. Fisiopat. clin. ter. 34, 319–337 (1962).PubMedGoogle Scholar
  260. Pollycove, M.: Discussion on sites of formation. In: Erythropoiesis, p. 102. New York: Grune & Stratton 1962.Google Scholar
  261. Prentice, T.C., and E.A. Mirand: Some aspects of the relationship between plasma and urine erythropoietin. Proc. Soc. exp. Biol. (N. Y.) 109, 414 (1962).CrossRefGoogle Scholar
  262. Prins, H.K., M. Oort, J. A. Loos, C. Zürcher, and Th. Beckers: Hereditary absence of glutathione in the erythrocytes. Biochemical, hematological and genetical Studies. Proc. 9. Congr. Europ. Soc. Hematol. P. VII, p. 722, 1963.Google Scholar
  263. Puchlev, A., N. Popov, A. Astrug, D. Dotschevu. S. Petrinska: Über die endemische Nephritis in Bulgarien. Schweiz, med. Wschr. 91, 751–756 (1961).Google Scholar
  264. A Racker: Methods of enzymology, vol. 2, p. 722. Academic Press 1955.Google Scholar
  265. Ragen, P. A., A. S. Hagedorn, and C.A. Owen Jr.: Radioisotopic study of anemia in chronic renal disease. Arch, intern. Med. 105,518 (1960).CrossRefGoogle Scholar
  266. Rambach, W. A., H.L. Alt, and J. A.D. Cooper: The mode of action an nature of a heat stable plasma erythropoietic factor. Blood 12, 1101 (1957).PubMedGoogle Scholar
  267. Rambach, W. A.; Erythropoietic activity of tissue homogenates. Proc. Soc. exper. Biol. (N.Y.) 108, 793 (1961).CrossRefGoogle Scholar
  268. Rambach, W.A., J.A.D. Cooper, and H.L. Alt: Erythropoietic effect of tissue homogenates. J. Lab. clin. Med. 56, 938 (1960).Google Scholar
  269. Rambach, W.A.; Erythropoietic activity of tissue homogenates. Proc. Soc. exper. Biol. (N.Y.) 108,793 (1961).CrossRefGoogle Scholar
  270. Rambach, W. A., and E. Kurtider: Azotemic anemia and the effect of hemodialysis. Trans. Amer. Soc. Artif. int. Organes 9, 61 (1963).Google Scholar
  271. Rath, C.E., P.R. McCurdy, and B.J. Duffy: Effect of renal disease in the Schillingtest. New Engl. J. Med. 256,111–114 (1957).PubMedCrossRefGoogle Scholar
  272. Rees, S.B., W. G. Scheitlin, C. Giordano, W.R. Guild, and J.P. Merrill: Pathologic physiology of the anemia associated with renal failure. Excerpta med. (Amst.), Ser. XXIX. First Int. Congr. Nephrology 1961, vol. 1, p. 67, 1961.Google Scholar
  273. Rees, S.B., W.G. Scheitlin, J.C. Pond, T. J. McManus, W.R. Guild, and J.P. Merrill: Effect of dialyses and purine ribosides upon the anemia of uremia (Abstrakt). J. clin. Invest. 36, 923 (1957).Google Scholar
  274. Reever G., L. Löwenstein, and S. C. Sommers: A suggested mechanism of erythropoietic control by juxtaglomerular cells. Amer. J. med. Sci. 184, 245 (1963).Google Scholar
  275. Reissmann, K.R.; Discussion on sites of formation. In: Erythropoiesis, p. 105. New York: Grune & Stratton 1962.Google Scholar
  276. Reissmann, K.R.; Discussion on relationship to anemia, polycythemia and renal abnormalities. In: Erythropoieses, p. 386. New York: Grune & Stratton 1962.Google Scholar
  277. Rambach, W. A.; Discussion on relationship to anemia, polycythemia and renal abnormalities. In: Erythropoiesis, p. 387. New York: Grune & Stratton 1962.Google Scholar
  278. Reissmann, K.R., and T. Nomura: Erythropoietin formation in isolated kidneys and liver. In:Erythropoiesis, p. 71. New York: Grune & Stratton 1962.Google Scholar
  279. Reissmann, K.R., T. Nomura, R.W. Gunn, and F. Brosius: Erythropoietic response to anemia or erythropoietin injection in uremic rats with or without functioning renal tissue. Blood 16, 1411–1423 (1960).PubMedGoogle Scholar
  280. Remmele, W., V. Palm, W. Erdmann, K. zum Winkel, H. Fries, and F. Rodriguez-Erdmann: Experimentelle Untersuchungen über die Wirkung verschiedener Hormone auf die Erythropoiese und über den Bildungsort des Erythropoietins. Proc. VIII Europ. Congr. Hemat. Wien II, S. 275, 1961.Google Scholar
  281. Riebet, G.: Anemie au cours des affections renales. 1. Congr. Int. Nephrol. Geneve/Evian 1960, p. 544–546, 1961.Google Scholar
  282. Riebet, G., D. Alagilleet E. Fournier: L’erythroblastopenie aigue de l’anurie. Presse med. 62, 50 (1954).Google Scholar
  283. Riebet, G., R. Ardaillon, et Y. Najeau: Insuffisance renaleet erythropoiese. Faits cliniqueet experimentaux. Bull. Soc. med. Hop. Paris 76, 599–608 (1960).Google Scholar
  284. Rifkind, R. A., and D. Danon: Heinz body anemia an ultrastructural study. Heinz-body formation. Blood 15, 976 (1965).Google Scholar
  285. Robinson, J.C., G.W. James, and R.M. Kark: The effect of oral therapy with cobaltous chloride on the blood of patients suffering with chronic suppurative infection. New Engl. J. Med. 240, 749–753 (1949).PubMedCrossRefGoogle Scholar
  286. Robinson, R.R., H.V. Murdaugh Jr., and E. Peschel: Renal factor responsible for the hypermagnesemia of renal disease. J. Lab. clin. Med. 53, 572 (1959).PubMedGoogle Scholar
  287. Rohr, K.: Das menschliche Knochenmark. Stuttgart: Georg Thieme 1941.Google Scholar
  288. Roscoe, M.H.: Anemia and nitrogen retention in patients with chronic renal failure. Lancet 19521, 444.Google Scholar
  289. Rosenbach, L. M., and E.D. Xefteris: Erythrocytosis associated with carcinoma of the kidney. J. Amer. me. Ass. 176, 136–137 (1961).CrossRefGoogle Scholar
  290. Rosse, W.F., R.J. Berry, and T.A. Waldmann: Some molecular characteristics of erythropoietin from different saurces determined by in-activation by ionizing radiation. J. clin. Invest. 42, 124 (1963).PubMedCrossRefGoogle Scholar
  291. Rosse, W.F., and T.A. Waldmann: The role of the kidney in the erythropoietic response to hypoxia in parabiotic rats. Blood 19, 75–81 (1962).PubMedGoogle Scholar
  292. Rosse, W.F., T.A. Waldmann, and P. Cohen: Renal cysts, erythropoietin and polycythemia. Amer. J. Med. 34, 76 (1963).PubMedCrossRefGoogle Scholar
  293. Rosse, W.F., T.A. Waldmann, and D.E. Houston: Erythropoietin assays using iron59-incorporation into-blood and spleen of the polycythemic mouse. Proc. Soc. exp. Biol. (N.Y.) 109, 836 (1962).CrossRefGoogle Scholar
  294. Rothlin, E., E. Undritz,u. K. Zehnder: Die tierexperimentellen Grundlagen der therapeutischen Anwendung von Kobalt, Kupfer und Eisen bei bestimmten Anaemien. Schweiz, med. Wschr. 86, 1428–1435 (1956).Google Scholar
  295. Roujeau, J., et P. Aboulker: Cancer du rein, polycythemic et Erythroblastose locale (A propos de trois observations). Presse med. 1960, 156.Google Scholar
  296. Sacchetti, C.: Physiopathologie des erythroblastes dans les anemies chroniques. Acta haemat. (Basel) 9, 97 (1953).CrossRefGoogle Scholar
  297. Sailer, S., F. Sandhof eru. H. Braunsteiner: Enzymgehalt der Erythrozyten und effektive Erythropoiese. Wien. Z. inn. Med. 44, 31 (1963).PubMedGoogle Scholar
  298. Sarre, H.: Nierenkrankheiten. Stuttgart-Georg Thieme 1958.Google Scholar
  299. Sarre, H.,u. P. Schadkhu: Extrarenale Azotaemie im Durstzustand und bei erhöhtem Stickstoffanfall. Klin. Wschr. 40,179 (1962).PubMedCrossRefGoogle Scholar
  300. Scheuch, F.,u. S. Rapoport: Das Verhalten von anorganischer Pyrophosphatase, Triosephosphatdehydrogenase und Glukose-6-phosphat-dehydrogenase bei Oxydation ihrer essentiellen SH-Gruppen. Acta biol. med. germ. 8, 31 (1962).PubMedGoogle Scholar
  301. Schleisner, P.: Cobalt in anemia. Acta med. scand. 154, 177–185 (1956).PubMedCrossRefGoogle Scholar
  302. Schürmeyer, E.,u. H. Losse: Polyglobulie bei Nierenerkrankungen. Med. Welt 1962, 29–33.Google Scholar
  303. Smith, H.: Pre-azotemic renal anemia: a clinical hypothesis supported by animal experiment. Brit. J. Urol. 35, 33–40 (1963).PubMedCrossRefGoogle Scholar
  304. Smith, W. O., and J.F. Hammersten: Intracellular magnesium in delirium tremens and uremia. Amer. J. med. Sci. 237, 413 (1959).PubMedCrossRefGoogle Scholar
  305. Sokabe, H., and A. Grollman: Localization of blood pressure regulating and erythropoietic functions in rat kidney. Amer. J. Physiol. 203, 991 (1962).PubMedGoogle Scholar
  306. Spiihler, O.: Die chronische „Pyelonephritis". Eine chronische destruierende Nephritis und Nephropyelitis. Schweiz, med. Wschr. 91, 1079–1085 (1961).Google Scholar
  307. Steiger, R.P.,u. H. M. Keller: Nierenfunktion und Desferrioxamin. Helv. med. Acta 30, 512 (1963).PubMedGoogle Scholar
  308. Stohlmann Jr. FR.: Humoral regulation of erythropoiesis. VI. Mechanism of action of erythropoietine in the irradiated animal. Proc. Soc. exp. Biol. N.Y. 107, 751 (1961).CrossRefGoogle Scholar
  309. Stohlmann Jr., F., and D. Howard: Humoral regulation of erythropoiesis. IX. The rate of disappearance of erythropoietin from the plasma. In: Erythropoiesis, p. 120. New York: Grune & Stratton 1962.Google Scholar
  310. Suhrland, L.G., and A.S. Weisberger: Correlation of erythropoietic toxicity with the serum concentration of chloramphenicol metabolites in patients with renal or hepatic insufficiency. J. Lab. clin. Med. 60, 1022 (1962).Google Scholar
  311. Suki, W., and A. Grollman: Role of the kidney in erythropoiesis. Amer. J. Physiol. 199, 4 (1960).Google Scholar
  312. Tada, K., Y. Watanabe, and T. Fujiwara: The enzyme activities and coenzyme contents in the reticulocytes of rabbits. Tohoku J. exp. Med. 75, 384 (1961).CrossRefGoogle Scholar
  313. Takaku, F., K. Hirashima. and K. Nakao: Studies on the mechanism of erythropoietin production. I. Effect of unilateral constriction of the renal artery. J. Lab. clin. Med. 59, 815 (1962).PubMedGoogle Scholar
  314. Takaku, F., and S. Okinaka: Studies on the mechanism of erythropoietin production. II. Effect of bilateral section of the splanchnic nerves. J. Lab. clin. Med. 59, 821 (1962).PubMedGoogle Scholar
  315. Theil, G.B., C.E. Brodine, and F.D. Doolan: Red cell glutathione content and stability in renal insufficiency. J. Lab. clin. Med. 58, 736 (1961).PubMedGoogle Scholar
  316. Thiel, G.: Polycythaemie bei Nierengeschwülsten. Dtsch. Arch. klin. Med. 208,111–134 (1962).PubMedGoogle Scholar
  317. Tobian, L., J. Thompson, R. Twedt, and J. Janacek: The granulation of juxtaglomerular cells in renal hypertension, desoxycorticosterone and postdesoxycorticosterone hypertension, adrenal regeneration hypertension and adrenal insufficiency. J. clin. Invest. 37, 660 (1958).PubMedCrossRefGoogle Scholar
  318. Townsend, S.R., E. Marsie, and R.H. Lyons: Studies in the anemia of chronic glomerulonephritis and its relationship to gastric acidity. Amer. J. med. Sd. 194, 636 (1937).CrossRefGoogle Scholar
  319. Verel, D., A. Turnbull, G.R. Tudhope, and J.H. Ross: Anemia in Bright’s disease. Quart. J. Med. 28, 491–504 (1959).PubMedGoogle Scholar
  320. Videbaek, A.: Polycythemia vera. Co-existing with malignant tumors (particulary hypernephroma). Acta med. scand. 138, 239–245 (1950).PubMedCrossRefGoogle Scholar
  321. Vogel, K.H.: Anaemie bei chronischer Niereninsuffizienz. Medizinische 19571, 110–118.Google Scholar
  322. Volhard, F.: Die doppelseitigen hämatogenen Nierenerkrankungen. In: Handbuch der inneren Medizin, 2. Aufl. Berlin: Springer 1931.Google Scholar
  323. Waldman, T.A., and W.F. Rosse: Sites of formation of erythropoietin. In: Erythropoiesis, p. 87–92. New York: Grune & Stratton 1962.Google Scholar
  324. Walker, I.M.: Survival after haemoptysis and nephritis. Lancet 1963 II, 1199–1201.Google Scholar
  325. Waller, H.D.: Total hemoglobin content in chronic kidney disease. Med. Klin. 58, 2130–2135 (1963).PubMedGoogle Scholar
  326. Waller, H.D., G.E. Lohr, E. Zysno, W. Gerok, D. Vossu. G. Strauss: Glutathionreduktase-Mangel mit hämatologischen und neurologischen Störungen. (Autosomal dominant vererbliche Bildung eines pathologischen Enzyms). Klin. Wschr. 8, 413 (1965).CrossRefGoogle Scholar
  327. Waller, H.D.,u. W. Stahl: Der Gesamthämoglobin-(Hbi)-Gehalt bei chronischen Nierenerkrankungen. Med. Klin. 58, 2130 (1963).PubMedGoogle Scholar
  328. Weinsaft, P.P.: Cobaltous chloride in the treatment of certain refractory anemias. Amer. J. med. Sci. 230, 264 (1955).PubMedCrossRefGoogle Scholar
  329. Eelssberger, A. S.: Discussion on in vitro studies. In: Erythropoiesis, p. 328. New York: Grune & Stratton 1962.Google Scholar
  330. Wernze, H.,u. W. Koch: Über den Glutathion-(GSH) Gehalt der Erythrozyten bei chronischer renaler Insuffizienz. Klin. Wschr. 8, 451 (1965).CrossRefGoogle Scholar
  331. Wernze, H.; Papierchromatographische Trennung und quantitative Bestimmungsmethode für SH-Glutathion in Blut und Geweben. Klin. Wschr. 8, 454 (1965).CrossRefGoogle Scholar
  332. Whitby, L.E.H., and C. J.C. Britton: Disorders of the blood, 5. ed., p. 57. London: Churchill 1946.Google Scholar
  333. Zangheri, E.O., H. Campana, F. Ponce, J. C. Silva, F.O. Fernendez, and J. R. Suarez: Production of erythropoietin by anoxic perfusion of the isolated kidney. Nature (Lond.) 199, 572 (1963).CrossRefGoogle Scholar
  334. Zondek, H.: Der Einfluß kleiner Thyreoidinmengen auf das rote Blutbild. Dtsch. med. Wschr. 1, 1033 (1922).CrossRefGoogle Scholar

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  • H. M. Keller

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